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Einstein receives $30 million to study protein form and function
Date:9/30/2010

ar phase, called PSI:Biology, which will support four large-scale centers that will operate pipelines for determining protein structures nominated by the scientific community or identified by collaborating biologists. Among these centers is the New York Structural Genomics Research Consortium (NYSGRC), which is based at Einstein and has been part of PSI since its inception.

Under Einstein's leadership, NYSGRC will initially work with two PSI partnership centers to concentrate on particular areas of biological interest. One of NYSGRC's partners is the Immune Function Network (IFN), a consortium of immunologists, geneticists, computational biochemists and high-throughput structural biologists led by Stanley Nathenson, M.D., Samuel H. Golding Chair in Microbiology, and distinguished professor of microbiology & immunology and of cell biology at Einstein, as well as Almo. Together, NYSGRC and IFN will study cell surface molecules that control the immune response, as well as substances that major bacterial, protozoan and fungal pathogens secrete to evade the immune system or to modulate host signaling pathways. "We hope that the synergy between the IFN and the NYSGRC will lead to the development of new strategies and new molecules that are useful in the clinic," says Dr. Almo, who is also scientific director of Einstein's macromolecular therapeutics development facility, where much of the research will take place.

The second partnership, with Stanford University and the Sanford-Burnham Medical Research Institute, will focus on proteins involved in cell adhesion, the process by which cells recognize and bind to other cells and structures in the body. It is anticipated that additional PSI partnership centers will join NYSGRC in the future.<
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Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

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