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Einstein receives $30 million to study protein form and function
Date:9/30/2010

September 30, 2010 (BRONX, NY) The National Institute of General Medical Sciences (NIGMS) has awarded Albert Einstein College of Medicine of Yeshiva University a five-year, $30 million grant to study the structure and function of thousands of biomedically important proteins.

"Determining the structures of proteins is the first step toward understanding their role in normal biological processes as well as in disease pathways," says principal investigator Steven Almo, Ph.D., professor of biochemistry and of physiology & biophysics at Einstein. "Using this knowledge, we can begin to learn how proteins can be modified to create new, highly targeted therapies for disease."

Proteins are key building blocks of all living things. They are involved in all normal bodily processes including movement, metabolism and cognition. They also play central roles in a wide range of illnesses, including autoimmune diseases, infectious diseases and cancer.

The Einstein research is part of the NIGMS's Protein Structure Initiative (PSI), a decade-long federal, university and industry effort aimed at dramatically reducing the costs and lessening the time it takes to determine a three-dimensional protein structure from its DNA sequence.

"The PSI has been incredibly successful in establishing high-throughput pipelines that have led to more than 5,000 structures, most unlike any we've seen before," says Jeremy Berg, Ph.D., director of NIGMS, a division of the National Institutes Health (NIH). "Now it's time to deploy these capabilities so we can advance our understanding of the role proteins play in health and disease."

PSI is entering its third five-ye
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Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

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