Navigation Links
Einstein receives $12 million grant to develop device for preventing HIV infection
Date:3/8/2013

March 7, 2013 (Bronx, NY) Researchers at Albert Einstein College of Medicine of Yeshiva University have been awarded a $12 million grant from the National Institutes of Health (NIH) to develop a drug-impregnated intravaginal ring to prevent HIV infection in women.

"As we move into the fourth decade of the HIV pandemic, the disease is having its greatest impact on women, particularly in sub-Sahara Africa," said principal investigator Betsy Herold, M.D., professor of pediatrics, of microbiology & immunology, and of obstetrics & gynecology and women's health at Einstein and attending physician of pediatrics, The Children's Hospital at Montefiore.

According to UNAIDS, approximately 34 million people are living with HIV worldwide. Sub-Saharan Africa is the region most affected and accounts for 69 percent of all people living with HIV.

"To protect these women and slow the epidemic, we urgently need safe and effective prevention strategies," said Dr. Herold.

Dr. Herold and co-investigator Patrick Kiser, Ph.D., a bioengineer at the University of Utah, previously developed an intravaginal ring that delivers a potent antitretroviral drug for more than four weeks and proved highly active against HIV in laboratory studies. But learning whether the device's preclinical performance will translate into real-world effectiveness has proven difficult.

The ideal intravaginal ring must release sufficient concentrations of drug to protect women at increased risk of HIV infection. And it will contain drugs that are:

  • active in the vagina, cervix and rectum;
  • capable of both rapid and sustained drug delivery for at least one month;
  • effective against many different HIV subtypes;
  • safe;
  • inexpensive;
  • stable without needing refrigeration.

The five-year project will determine if the drug released from the ring retains anti-HIV activity in the presence of vaginal secretions. In addition, studies involving non-human primates aimed at optimizing the vaginal ring's design will be conducted at the Centers for Disease Control and Prevention.

In tests to see if two drugs work better than one, the ring will be impregnated with a second drug that inhibits HIV through a mechanism different from the first drug. A clinical study to assess the ring's safety will also be carried out; this part of the project will include U.S. women taking oral contraceptives.

The grant will also fund a clinical study to assess safety and pharmacokinetics in women on Depo Provera in Kenya (led by Jeanne Marrazzo, M.D., M.P.H., from the University of Washington, and Nelly Mugo, M.P.H., from Kenyatta National Hospital) and in U.S. women on oral contraceptive pills (led by Marla Keller, M.D., associate professor of medicine and of obstetrics & gynecology and women's health at Einstein and attending physician of medicine at Montefiore Medical Center, the University Hospital for Einstein).

"We're optimistic that the intravaginal approach to preventing HIV infection will overcome the problem of having to remember to use oral or gel products daily and will empower women to protect themselves against HIV," says Dr. Herold.

Dr. Herold has worked extensively to translate laboratory research into effective real-world preventive measures for HIV. She previously developed a laboratory test that predicts whether microbicides against HIV are safe for human use.


'/>"/>

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Related biology news :

1. Einstein researchers receive 2 Grand Challenges Explorations grants to combat HIV and TB
2. Feinstein Institute receives $1 million grant to study impact of World Trade Center attacks on responders
3. Einstein hosts its first stem cell institute symposium
4. Einstein researcher receives $10.8 million grant to study toxic blood reactions caused by hemoglobin
5. Wayne State vision restoration technology receives Notice of Allowance for US patent app
6. BU researcher receives highest honor from the National Birth Defects Prevention Network
7. Geneticist Svante Pääbo receives the $500,000 Gruber Genetics Prize
8. Artificial retina receives FDA approval
9. NTU Provost receives prestigious Imperial College fellowship joining the ranks of top UK scientists
10. Xenon Receives a Milestone Payment for Marketing Approval of Glybera in Europe
11. Brainwave "Balancing" Research Receives $1 Million Grant From The Susanne Marcus Collins Foundation, Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... TURKU, Finland , June 9, 2016 ... French National Police deploy Teleste,s video security solution to ensure ... France during the major tournament ... and data communications systems and services, announced today that its ... Police Prefecture to back up public safety across ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, ... Infrastructure, Support & Other Service  The latest ... comprehensive analysis of the global Border Security market ... of $17.98 billion in 2016. Now: In ... in software and hardware technologies for advanced video surveillance. ...
(Date:5/12/2016)... -- WearablesResearch.com , a brand of Troubadour Research ... the Q1 wave of its quarterly wearables survey. A ... to a program where they would receive discounts for ... "We were surprised to see that so ... , CEO of Troubadour Research, "primarily because there are ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... 2016 , ... Cancer experts from Austria, Hungary, Switzerland, and ... new and helpful biomarker for malignant pleural mesothelioma. Surviving Mesothelioma has just published ... , Biomarkers are components in the blood, tissue or body fluids that ...
(Date:6/27/2016)... ... 2016 , ... Newly created 4Sight Medical Solutions ... healthcare market. The company's primary focus is on new product introductions, to include ... are necessary to help companies efficiently bring their products to market. , The ...
(Date:6/27/2016)... 2016  Liquid Biotech USA ... a Sponsored Research Agreement with The University of ... from cancer patients.  The funding will be used ... with clinical outcomes in cancer patients undergoing a ... be employed to support the design of a ...
(Date:6/24/2016)...  Regular discussions on a range of subjects including policies, ... entities said Poloz. Speaking at a lecture to ... he pointed to the country,s inflation target, which is set ... "In certain areas there needs ... economic goals, why not sit down and address strategy together?" ...
Breaking Biology Technology: