Navigation Links
Egg meets sperm: The female side of the story
Date:10/21/2010

Researchers at the Swedish medical university Karolinska Institutet have been able to describe the 3D structure of a complete egg receptor that binds sperm at the beginning of fertilization. The results, published in the journal Cell, will lead to better understanding of infertility and may enable entirely new types of contraceptives.

For centuries, the imagination of people has been grasped by the encounter of gametes egg and sperm-, whose union gives rise to a new individual. At the beginning of conception, sperm binds to proteins in the extracellular coat of the egg, called zona pellucida (ZP). But the molecular details of this fundamental biological event have so far remained obscure.

Luca Jovine's research team at Karolinska Institutet has now managed to determine the three-dimensional structure of the receptor molecule that binds sperm, called ZP3 (see press photos). The detailed structural information, based on data collected at the European Synchrotron Radiation Facility (ESRF), makes it possible to begin exploring at the molecular level how the egg interacts with sperm at fertilization.

The study suggests which parts of the receptor are likely to be directly contacted by sperm, and provides new insights into how the sperm receptor is assembled and secreted from the egg. The findings have important implications for human reproductive medicine, as they may explain how mutations in the sperm receptor gene could cause infertility. The research could also potentially lead to the design of non-hormonal contraceptives specifically targeting egg-sperm interaction.

"The results give a remarkable picture of the female side of fertilization", says Luca Jovine, who has led the study. "But this is, of course, only half of the story. The next step will be to tackle the corresponding molecules on sperm that allow it to bind to the egg."


'/>"/>

Contact: Press Officer Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Page: 1

Related biology news :

1. Climate change meets ocean life in new northeast research institute
2. Georgia Stem Cell Initiative meets on MCG campus Feb. 10
3. Where optics meets medicine
4. A new journal where molecular biology meets clinical research
5. Female fish flaunt fins to attract a mate
6. Female marine snails trick amorous males
7. Rice sociologist finds male scientists regret parenthood decisions more than female counterparts
8. Male antelopes trick females into extra sex opportunities
9. Male antelopes deceive females to increase their chances of mating
10. Male or female? In flies, some cells cant tell
11. Hormonal contraceptives associated with higher risk of female sexual dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... NASA story from 2009, "human activities in this area of ... Palm oil is increasingly grown for use as a cooking ... foods. It has become the most widely produced edible oil ... to surpass that of soybean oil. , The environmental effects ... cleared to grow the crop, and the preferred method is ...
(Date:9/29/2014)... Parents with children at home should use ventilation when ... University are recommending, after a new study showed an ... symptoms and chronic bronchitis. , "In homes where a ... asthma and wheezing is higher than in homes where ... Smit, an associate professor in the College of Public ...
(Date:9/29/2014)... support the world,s needs to make cheaper and ... and more efficient catalytic materials and processes must ... from Wayne State University, is tackling this problem ... the National Science Foundation. , The nearly $1.5 ... for Electrocatalytic Cascade Reactions," was to Eranda Nikolla, ...
Breaking Biology News(10 mins):Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 3Wayne State research aims to develop new, more efficient catalytic materials 2
... are a major cause of plant diseases and are ... and other cereals all over the world. Together with ... from the Max Planck Institute for Terrestrial Microbiology in ... the University of Gttingen, analysed the genetic make-up of ...
... years in the Bering Sea have been the coldest on ... cold temperatures have helped produce larger zooplankton in the Bering ... Alexei Pinchuk, research professional at the UAF Seward Marine Center, ... the Bering Sea. He and his colleagues have been looking ...
... 9, 2010 -- A quicker and cheaper technique to ... Oak Ridge National Laboratory could put scientists on the ... team led by Jerome Baudry of the University of ... existing software to allow supercomputers such as ORNL,s Jaguar ...
Cached Biology News:Evolutionary arms race between smut fungi and maize plants 2Evolutionary arms race between smut fungi and maize plants 3Supercomputing research opens doors for drug discovery 2
(Date:10/1/2014)... 2014 The participants committed to not ... spending their own time adjusting, tweaking and testing virtual ... were ready for judging. , “I enjoyed being involved ... leader. “The entries showed a commendable range exploring ... of the print medium and the creativity of the ...
(Date:10/1/2014)... BOSTON, MA (PRWEB) September 30, 2014 ... company, SoundConnect announces four new-hosted collaboration ... innovative bundles deliver high quality conferencing experiences for ... collaboration packages to choose from, businesses have optimized ... bundled solutions include audio only minutes ...
(Date:10/1/2014)... 2014 This report analyzes the ... Million by the following Product Segments: Proteases, ... end-use segments also analyzed are Pharmaceuticals & ... report provides separate comprehensive analytics for the ... and Latin America. Annual estimates and forecasts ...
(Date:9/30/2014)... news release is available in German . ... the Technische Universitt Mnchen (TUM) have demonstrated a new ... experiments show that future computer chips could be based ... As the main enabling technology of the semiconductor industry ... limits, the TUM researchers and collaborators at the University ...
Breaking Biology Technology:Array Architects Challenges Staff to Create with 3D Printer 2SoundConnect Launches New Audio, Web and Video Bundles 2Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3
... out with Los Angeles for second place in the roster ... community is finite. , ,In Milwaukee and throughout the Midwest, ... that the technology business community is even smaller. People know ... ,One of the inevitable outcomes of spending some years working ...
... has fired yet another salvo into the human-cloning battle, which ... therapeutic researchers to grow cloned embryos with up to around ... Legal Committee this week recommended that the General Assembly call ... cloning inasmuch as they are incompatible with human dignity and ...
... pulling some long-term information technology projects into the spotlight. CIOs ... in IT turn into radical new advances in health care, ... to the Fusion 2005 CEO-CIO Symposium on March ... their views on the emerging information technology of the year. ...
Cached Biology Technology:How name-dropping can make interviews fail 2How name-dropping can make interviews fail 3How name-dropping can make interviews fail 4UN committee opposes human cloning 2UN committee opposes human cloning 3Wisconsin CIOs look for an IT tipping point 2Wisconsin CIOs look for an IT tipping point 3
HLA II DG+DR+DP Monoclonal Antibody, Purified, Unconjugated, Clone: IQU9 This antibody is specific for the monomorphic determinant of the HLA Class II beta chains of the human MHC (28 kDa)....
Phenytoin-BSA Isolated IgY DFc Drug...
Tropomyosin 4 [Tm4]...
Mouse monoclonal [2A4] to Cytokeratin 8 + 18 + 19 ( Abpromise for all tested applications). Antigen: Cytokeratins isolated from cultured pig kidney epithelial cells. Entrez GeneID: 3856 S...
Biology Products: