Navigation Links
Effects of prenatal stress passed across generations in mice
Date:8/17/2011

Washington, DC Sons of male mice exposed to prenatal stress are more sensitive to stress as adults, according to a study in the August 17 issue of The Journal of Neuroscience. These findings suggest experiences in the womb can lead to individual differences in stress response that may be passed across generations.

Tracy Bale, PhD, of the University of Pennsylvania, and colleagues previously found that male mice were sensitive to stress their mothers experienced during pregnancy. In the current study Bale, together with Chris Morgan, also of the University of Pennsylvania, bred those stress-sensitive males with normal females to see if the heightened stress response could be transmitted to the next generation of mice. Even though the male offspring had no additional exposure to stress in the womb, they displayed a more pronounced reaction to stress, just like their fathers.

"This study shows that the effects of maternal stress in mice are passed by the sons to the grandsons of the stressed mothers," said Arthur Arnold, PhD, an expert on sex differences in the brain at the University of California, Los Angeles. "Since male mice are not involved in rearing the offspring in the lab setting, the findings suggest that the transmission of the trait from son to grandson is through the son's DNA," added Arnold, who was unaffiliated with the study.

In general, female mice tend to respond more to stress than do males. However, in the current study, the sons and grandsons of female mice that were stressed while pregnant showed a stress response more similar to female mice.

Compared with other male mice, the stress-sensitive grandsons also had smaller testes, as did their fathers, suggesting they were exposed to less testosterone around birth a critical period for establishing sex differences in the brain. Additionally, genes involved in brain development were turned on and off in a pattern more similar to female than male mice.

"Together these findings suggest prenatal stress may disrupt masculinization of the developing mouse brain," Bale said. Although such changes did not deter the stress-sensitive male mice from reproducing, the results suggest exposure to stress during early pregnancy can lead to long-term changes in offspring that can be passed across generations.


'/>"/>

Contact: Kat Snodgrass
ksnodgrass@sfn.org
202-962-4090
Society for Neuroscience
Source:Eurekalert

Related biology news :

1. Earth: 9/11s lingering effects: Tracking the long-term impact of the dust
2. Antioxidant spices reduce negative effects of high-fat meal
3. Waging war on invasive plant species: Effects of invasives persist even after removal
4. USDA scientists study effects of rising carbon dioxide on rangelands
5. Harmful effects of hypothyroidism on maternal and fetal health drive new guidelines for managing thyroid disease in pregnancy
6. Exercise has numerous beneficial effects on brain health and cognition, review suggests
7. Grazing management effects on stream pollutants
8. Loss of top animal predators has massive ecological effects
9. NIH-funded research network to explore oil spill health effects
10. LSUHSC conducts landmark study of mid, long-term health effects of oil exposure
11. Preventing diabetes damage: Zincs effects on a kinky, two-faced cohort
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... 30, 2017 The research team of The ... (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery ... of speed and accuracy for use in identification, crime investigation, immigration ... ... A research team ...
(Date:3/29/2017)... CHICAGO , March 29, 2017  higi, the ... ecosystem in North America , today ... Partners and the acquisition of EveryMove. The new investment ... extensive set of tools to transform population health activities ... and lifestyle data. higi collects and secures ...
(Date:3/27/2017)... N.Y. , March 27, 2017  Catholic ... Information and Management Systems Society (HIMSS) Analytics for ... EMR Adoption Model sm . In addition, CHS ... of U.S. hospitals using an electronic medical record ... for its high level of EMR usage in ...
Breaking Biology News(10 mins):
(Date:8/21/2017)... ... August 21, 2017 , ... ... its extensive experience with Health Economics and Outcomes Research (HEOR) and ‘big data’ ... In 2014, US healthcare spending exceeded $3.0 trillion with nearly 1/3 spent on ...
(Date:8/18/2017)... ... August 18, 2017 , ... OAI, a leading Silicon Valley, ... Industries, announces the new Model 800E front and backside, semi-automatic mask aligner system. ... aligners. OAI has already received and installed several orders for the ...
(Date:8/16/2017)... ... August 16, 2017 , ... Nanoscience ... Electrospraying line of nanofiber and nanoparticle fabrication instruments from Bioinicia. The ... fully automated pilot plants and equipment for industrial manufacturing. All equipment is ...
(Date:8/16/2017)... ... 16, 2017 , ... We are proud to announce the ... our Dilworth, MN site. The inspection took place Monday, July 31st through Friday, ... of a routine Bioresearch Monitoring Program (BIMO) with the USFDA wherein multiple Dermatology ...
Breaking Biology Technology: