Navigation Links
Effects of meth use on brain metabolism, sleep studied
Date:2/27/2014

SPOKANE, Wash. WSU sleep scientist Jonathan Wisor has received a grant from the National Institutes of Health (NIH) to study the effects of chronic methamphetamine use on brain metabolism and sleep. The two-year, $395,577 grant comes from the National Institute on Drug Abuse (NIDA), which is part of the NIH.

He will explore a seemingly contradictory pairing of symptoms in chronic methamphetamine users who are trying to kick the habit: excessive daytime sleepiness and the excessive use of glucose by the brain.

Sleep typically causes the brain to use less glucose, which is its main source of fuel, he said. However, chronic methamphetamine users exhibit a high rate of glucose utilization in the brain paired with excessive sleepiness.

Wisor thinks the answer to this paradox can be found in a biochemical series of events triggered by sleep. This helps clean up the brain's synapses, maintaining those connections between brain cells that are truly necessary and getting rid of other, less useful, connections.

The process contributes to the efficiency of the brain's use of metabolic fuels and "is dependent on a good night's sleep," he said. "What I think we may be able to show with these studies is that methamphetamine disrupts the signals that promote these sleep-dependent changes of the synapses."

In other words, the problem might not be in the quantity but the quality of sleep.

If the study confirms his hypothesis, it would be a significant step in understanding the brain mechanisms that underlie sleep. It could pave the way for development of a pharmaceutical intervention to reverse the methamphetamine disruption.

"Such an intervention might help chronic meth users get more restorative sleep, so they would wake up in the morning feeling ready to face the day without having to take methamphetamine to do so," Wisor said. "That's the hope."

Wisor, associate professor of medical sciences who is associated with the WSU Sleep and Performance Research Center and the College of Veterinary Medicine's Department of Integrative Physiology and Neuroscience, is working with several other researchers on this study. They include Ilia Karatsoreos, assistant professor in the WSU College of Veterinary Medicine, and Michael Rempe, assistant professor of mathematics at Whitworth University. Researchers from the University of Arizona and NIDA serve as consultants.


'/>"/>

Contact: Jonathan Wisor
j_wisor@wsu.edu
509-358-7577
Washington State University
Source:Eurekalert

Related biology news :

1. Climate engineering: Minor potential, major side effects
2. Drifting herbicides produce uncertain effects
3. Electronically controlled drugs could minimize side effects
4. New study examines the effects of catch-and-release fishing on sharks
5. New molecule protects brain from detrimental effects linked to diabetes and high blood sugar
6. Researchers collaborate to reduce effects of the aging eye
7. Key species of algae shows effects of climate change over time
8. Virginia Tech engineer receives NSF grant to study Colorado flood effects on antibiotic resistance
9. New research: Effects of eating half an avocado with lunch on satiety & desire to eat between meals
10. Updating air pollution measurement methods with air quality, health effects research
11. Breast cancer patients experience fewer side effects from anticancer drug when receiving acupuncture
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/19/2016)... , Nov. 18, 2016 Securus Technologies, ... solutions for public safety, investigation, corrections and monitoring, announced ... smaller competitor, ICSolutions, to have an independent technology judge ... the most modern high tech/sophisticated telephone calling platform, and ... customers that they do most of what we do ...
(Date:11/15/2016)...  Synthetic Biologics, Inc. (NYSE MKT: SYN), a ... gut microbiome, today announced the pricing of an ... common stock and warrants to purchase 50,000,000 shares ... the public of $1.00 per share and accompanying ... offering, excluding the proceeds, if any from the ...
(Date:6/27/2016)... Research and Markets has announced the addition of the ... The report forecasts the biometrics ... a CAGR of 12.28% during the period 2016-2020. ... with inputs from industry experts. The report covers the market landscape ... includes a discussion of the key vendors operating in this market. ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... MA (PRWEB) , ... December 02, 2016 , ... Robots ... Light Event on December 3rd, 2016. The event, which is held on the ... work with helping Americans with Disabilities back into the workplace. Suitable Technologies is partnering ...
(Date:12/2/2016)... December 2, 2016 The immunohistochemistry (IHC) ... at a CAGR of 7.3% during the forecast period of 2016 ... diagnostic laboratories segment accounted for the largest share of immunohistochemistry (IHC) ... , ... global immunohistochemistry (IHC) market spread across 225 pages, profiling 10 companies ...
(Date:11/30/2016)... ... November 30, 2016 , ... BEI Kimco, a brand ... a flexure design that ensures high alignment accuracy by preventing unwanted shaft rotation. ... suited where extreme precision is required, such as in medical equipment, laboratory instrumentation, ...
(Date:11/30/2016)... , November 30, 2016 ... a few players hold a dominant share in the ... River Laboratories International, Inc., and Merck KGaA, held a ... 2015. Transparency Market Research observes that these companies are ... on development products that are do not require rabbit ...
Breaking Biology Technology: