Navigation Links
Effects of environmental toxicants reach down through generations
Date:3/2/2012

PULLMAN, Wash.A Washington State University researcher has demonstrated that a variety of environmental toxicants can have negative effects on not just an exposed animal but the next three generations of its offspring.

The animal's DNA sequence remains unchanged, but the compounds change the way genes turn on and offthe epigenetic effect studied at length by WSU molecular biologist Michael Skinner and expanded on in the current issue of the online journal PLoS ONE.

While Skinner's earlier research has shown similar effects from a pesticide and fungicide, this is the first to show a greater variety of toxicantsincluding jet fuel, dioxin, plastics, and the pesticides DEET and permethrinpromoting epigenetic disease across generations.

"We didn't expect them all to have transgenerational effects, but all of them did," Skinner told the technology website Gizmodo. "I thought hydrocarbon would be negative but it was positive too."

This tells researchers that the ability to promote transgenerational disease is "not simply a unique aspect for a unique compound" but a characteristic of many environmental compounds.

The field opens new ground in the study of how diseases develop. While toxicologists generally focus on animals exposed to a compound, Skinner's work further demonstrates that diseases can also stem from older, ancestral exposures that are then mediated through epigenetic changes in sperm.

The work also points the way to identify and diagnose exposures through the use of specific epigenetic molecular markers.

"In the future we might be able to use these epigenetic biomarkers to determine your ancestral and personnel exposure early in life, and to predict your susceptibility to get a disease later in life," Skinner says.

The study was funded by the U.S. Army to study pollutants that troops might be exposed to. Skinner and his colleagues exposed pregnant female rats to relatively high but non-lethal amounts of the compounds and tracked changes in three generations of offspring. The researchers saw females reaching puberty earlier, increased rates in the decay and death of sperm cells, and lower numbers of ovarian follicles that later become eggs. Future studies can use the molecular tools for risk assessment analysis.


'/>"/>

Contact: Michael Skinner
skinner@wsu.edu
509-335-1524
Washington State University
Source:Eurekalert

Related biology news :

1. Prolonged effects of a warming anomaly on grasslands
2. Effects of anthropogenic sound on marine mammals -- a research strategy
3. UC Riverside biochemists devise method for bypassing aluminum toxicity effects in plants
4. How to build crops that can beat aluminums toxic effects
5. Effects of climate change vary greatly across plant families
6. UNC, Yale partner to study effects of cocaine use on mother-infant relationships
7. Study reveals effects of unconscious exposure to advertisements
8. Climate change effects on imperiled Sierra frog examined
9. Ocean acidification could have broad effects on marine ecosystems
10. Stronger coastal winds due to climate change may have far-reaching effects
11. Chantix side effects no worse with depression history
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... -- Hunova, the first robotic gym for the rehabilitation and functional motor sense ... Genoa, Italy . The first 30 robots will be available ... USA . The technology was developed and patented at the IIT ... Movendo Technology thanks to a 10 million euro investment from entrepreneur Sergio ... ...
(Date:4/19/2017)... The global military biometrics market ... by the presence of several large global players. The ... major players - 3M Cogent, NEC Corporation, M2SYS Technology, ... 61% of the global military biometric market in 2016. ... military biometrics market boast global presence, which has catapulted ...
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 ... overexpression experiments and avoiding the use of exogenous expression plasmids. The simplicity of ... performing systematic gain-of-function studies. , This complement to loss-of-function studies, such as ...
(Date:10/11/2017)...  VMS BioMarketing, a leading provider of patient support solutions, ... Educator (CNE) network, which will launch this week. The VMS ... care professionals to enhance the patient care experience by delivering ... health care professionals to help women who have been diagnosed ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today announced ... to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B ... to cross the cell membrane and bind intracellular STAT3 and inhibit its function. ...
(Date:10/10/2017)... ... , ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. ... The event entitled “Stem Cells and Their Regenerative Powers,” was held on August ... MPVM was joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic ...
Breaking Biology Technology: