Navigation Links
Effects of environmental toxicants reach down through generations
Date:3/2/2012

PULLMAN, Wash.A Washington State University researcher has demonstrated that a variety of environmental toxicants can have negative effects on not just an exposed animal but the next three generations of its offspring.

The animal's DNA sequence remains unchanged, but the compounds change the way genes turn on and offthe epigenetic effect studied at length by WSU molecular biologist Michael Skinner and expanded on in the current issue of the online journal PLoS ONE.

While Skinner's earlier research has shown similar effects from a pesticide and fungicide, this is the first to show a greater variety of toxicantsincluding jet fuel, dioxin, plastics, and the pesticides DEET and permethrinpromoting epigenetic disease across generations.

"We didn't expect them all to have transgenerational effects, but all of them did," Skinner told the technology website Gizmodo. "I thought hydrocarbon would be negative but it was positive too."

This tells researchers that the ability to promote transgenerational disease is "not simply a unique aspect for a unique compound" but a characteristic of many environmental compounds.

The field opens new ground in the study of how diseases develop. While toxicologists generally focus on animals exposed to a compound, Skinner's work further demonstrates that diseases can also stem from older, ancestral exposures that are then mediated through epigenetic changes in sperm.

The work also points the way to identify and diagnose exposures through the use of specific epigenetic molecular markers.

"In the future we might be able to use these epigenetic biomarkers to determine your ancestral and personnel exposure early in life, and to predict your susceptibility to get a disease later in life," Skinner says.

The study was funded by the U.S. Army to study pollutants that troops might be exposed to. Skinner and his colleagues exposed pregnant female rats to relatively high but non-lethal amounts of the compounds and tracked changes in three generations of offspring. The researchers saw females reaching puberty earlier, increased rates in the decay and death of sperm cells, and lower numbers of ovarian follicles that later become eggs. Future studies can use the molecular tools for risk assessment analysis.


'/>"/>

Contact: Michael Skinner
skinner@wsu.edu
509-335-1524
Washington State University
Source:Eurekalert

Related biology news :

1. Prolonged effects of a warming anomaly on grasslands
2. Effects of anthropogenic sound on marine mammals -- a research strategy
3. UC Riverside biochemists devise method for bypassing aluminum toxicity effects in plants
4. How to build crops that can beat aluminums toxic effects
5. Effects of climate change vary greatly across plant families
6. UNC, Yale partner to study effects of cocaine use on mother-infant relationships
7. Study reveals effects of unconscious exposure to advertisements
8. Climate change effects on imperiled Sierra frog examined
9. Ocean acidification could have broad effects on marine ecosystems
10. Stronger coastal winds due to climate change may have far-reaching effects
11. Chantix side effects no worse with depression history
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/14/2016)... SARASOTA, Fla., Nov. 14, 2016  xG Technology, Inc. ... in providing critical wireless communications for use in challenging ... ended September 30, 2016. Management will hold a conference ... at 5:00 p.m. Eastern Time (details below). ... announced a $16 million binding agreement to acquire Vislink ...
(Date:6/22/2016)... 22, 2016  The American College of Medical Genetics and ... Magazine as one of the fastest-growing trade shows during ... the Bellagio in Las Vegas . ... of growth in each of the following categories: net square ... number of attendees. The 2015 ACMG Annual Meeting was ranked ...
(Date:6/21/2016)... , June 21, 2016 NuData ... the new role of principal product architect and ... the director of customer development. Both will report ... technical officer. The moves reflect NuData,s strategic growth ... response to high customer demand and customer focus ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... 2016 Biotest Pharmaceuticals Corporation (BPC), a leading ... the addition of its newest plasma collection center located ... . The 15,200 square foot state-of-the-art facility officially opened ... brings the total number of BPC,s plasma collection centers ... BPC,s Chief Executive Officer said "We are pleased to ...
(Date:11/30/2016)... -- Tempus, a technology company focused on supporting physicians ... Center have partnered to better determine which patients ... based on next generation genomic and transcriptomic sequencing. ... collaboration, Tempus will provide sequencing and analysis of ... Penn. Utilizing next-generation sequencing, machine learning and bioinformatics, ...
(Date:11/30/2016)... Connecticut , November 30, 2016 ... ... Aptuit, LLC today announced that ... library. An additional 150,000 novel compounds have increased the Screening ... to broaden the hit discovery capabilities of the company. This ...
(Date:11/30/2016)... ... November 30, 2016 , ... Energetiq Technology, a world leader ... generation, ultra-bright, Laser-Driven Light Source, the EQ-77, at the MRS Fall Exhibit 2016. ... offers higher radiance and irradiance from a truly broadband white light source. The ...
Breaking Biology Technology: