Navigation Links
Effectiveness of progesterone in reducing preterm births may be altered by genetic predisposition
Date:1/29/2009

SAN DIEGO, CA, JAN. 30, 2009 New research that may explain why taking progesterone to prevent preterm birth is only effective for some women was unveiled today at the 29th Annual Society for Maternal-Fetal Medicine (SMFM) meeting The Pregnancy Meeting.

The drug, 17 alpha-hydroxyprogesterone caproate (or 17P), a synthetic form of the progesterone hormone naturally produced during pregnancy, has been demonstrated in clinical trials to prevent some recurrent preterm births but not all.

"This study helps strengthen the theory that genetic variation in the human progesterone receptor plays an important role in the effectiveness of 17P," states Tracy Manuck, M.D., study author and SMFM member.

Women who have a spontaneous preterm delivery are at greatly increased risk of preterm delivery in subsequent pregnancies. Preterm birth is a leading cause of infant death in the United States and babies who survive face serious lifelong health problems. More than 543,000 babies are born too soon each year and recent federal statistics show that the nation's preterm birth rate has risen to 12.8 percent -- a 36 percent increase since the early 1980s.

"Dr. Manuck's research gives us a tantalizing clue as to why 17P works for some women, but not for others," said Alan R. Fleischman, M.D., senior vice president and medical director of the March of Dimes. "With further research along these lines, we hope to someday be able to prevent preterm birth from happening in the first place by screening women before they get pregnant, and identifying those whose babies could get a healthy start in life with the help of 17P."

The research, which was sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Unit Network and the University of Utah, assessed whether women with genetic variations known as single nucleotide polymorphisms (SNPs) in the human progesterone receptor gene we
'/>"/>

Contact: Elizabeth Lynch
elynch@marchofdimes.com
914-997-4286
March of Dimes Foundation
Source:Eurekalert

Page: 1 2

Related biology news :

1. UC health news: molecular pathway may predict chemotherapy effectiveness
2. Socioeconomic position associated with effectiveness of HIV drugs
3. MIT model could improve some drugs effectiveness
4. Trial seeks genetic fingerprint for predicting drug effectiveness
5. Quantitative PET imaging finds early determination of effectiveness of cancer treatment
6. Poll Shows Strong Doubts About Effectiveness of Federal Employment Verification System
7. New studies on the Mediterranean diet confirm its effectiveness for chronic disease prevention
8. RNA molecules, delivery system improve vaccine responses, effectiveness
9. New Study Reveals the Emotional Impact and Effectiveness of Negative Campaigning
10. Research shows cells inactive state is critical for effectiveness of cancer treatment
11. Corazonas Foods and Brandeis University partner to create cholesterol-reducing snacks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... 2014--Researchers at the Department of Energy,s Oak Ridge ... presented by R&D Magazine in recognition of the ... recognize the tremendous value of our National Labs," ... development at the National Labs continues to help ... the scientific and technological innovations necessary to remain ...
(Date:7/11/2014)... and Mineral Research awarded Michael F. Holick, PhD, MD, ... 2014 Louis V. Avioli Award. Holick, a professor of ... for revolutionizing the understanding of vitamin D and its ... a member of the American Society for Bone and ... mineral basic research. It is named for ASBMR,s first ...
(Date:7/11/2014)... "mouse TRAP" to capture the early signs of kidney ... the Journal of Clinical Investigation . Their new ... extract cellular and genetic information from a variety of ... Institute for Medical Research in 2008, TRAP involves attaching ... of the cell type of interest. Scientists can then ...
Breaking Biology News(10 mins):ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2
... Boston University have taught bacteria how to count. Professor ... sequence of genes that allow the microbes to count ... potential applications, which could include drug delivery and sensing ... application still to be addressed within synthetic biology: Can ...
... Each year the American Institute of Biological ... outstanding contributions to the biological sciences. Since ... annually to individuals who have made significant scientific ... fields of integrative and organismal biology. The ...
... Ludwig Institute for Cancer Research at the University of ... remarkable property of the contractile ring, a structure required ... works to divide the cell may facilitate development of ... The researchers show that even though both ...
Cached Biology News:Boston University biomedical engineers teach bacteria to count 2Boston University biomedical engineers teach bacteria to count 3Two Central High (Philadelphia) grads honored by AIBS 2Study may aid efforts to prevent uncontrolled cell division in cancer 2
(Date:7/11/2014)... , July 11, 2014 , Not ... in, into or from any jurisdiction where to do so ... jurisdiction.  Shire plc ("Shire" or the "Company") (LSE: ... this afternoon.  Shire confirms it has held a meeting with ... by Shire without the prior agreement or approval of AbbVie. ...
(Date:7/11/2014)... SEATTLE , July 11, 2014  Researchers ... navigate three-dimensional images. The new technology, called Virtual ... of small structures like neurons and synapses using ... Finger,s unique technology makes 3D imaging studies orders ... resources at an unprecedented level across many areas ...
(Date:7/10/2014)... Understanding the need for better quality and higher ... that currently exists in this area, ChanTest has recently ... validated ion channel and GPCR cell lines. ChanTest’s ... channels control many critical physiological functions throughout the body. ... to treat a variety of human diseases. , ...
(Date:7/10/2014)... 10, 2014 EvoDerma ’s NOOME Anti-Aging ... rejuvenating device now comes with a second treatment cup to ... , The new cup is thinner on the edges for ... target rough, thin and uneven surfaces on the face, neck ... a stimulating treatment on areas such as the cheeks and ...
Breaking Biology Technology:Shire plc - Statement re: Media Speculation 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2
... Md., Aug. 30 Micromet, Inc.,(Nasdaq: MITI ... of,novel, proprietary antibody-based products for cancer, inflammation and,autoimmune ... and,Chief Executive Officer of Micromet, will present at ... Germany on Wednesday,September 5, 2007 at 9:50am Eastern ...
... Aug. 29 Sucampo,Pharmaceuticals, Inc. (Nasdaq: SCMP ) ... have exercised in full their option to,purchase 562,500 shares ... that the closing of that purchase took place on ... closing were sold by a selling,stockholder and Sucampo did ...
... Mass., Aug. 29 Millennium,Pharmaceuticals, Inc. (Nasdaq: ... presentation,at the Thomas Weisel Partners 2007 Healthcare ... accessed by visiting the Investors section of ... http://www.newscom.com/cgi-bin/prnh/19991220/MLNMLOGO ) The presentation ...
Cached Biology Technology:Micromet, Inc. to Present at the Sal. Oppenheim 2nd European Healthcare Conference 2Sucampo Pharmaceuticals Announces Exercise and Closing of IPO Over-Allotment Option 2Thomas Weisel Partners 2007 Healthcare Conference To Webcast Millennium Presentation 2
Protein Kinase D2 Immunogen: Human protein kinase D2. Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
... Upright Freezer Inventory Storage Racks for ... available to fit all makes and ... Made of high quality stainless ... high fiberboard, stainless steel or plastic ...
Many mammalian cell types and experimental situations create challenges for standard transfection experiments. The ViraPower Lentiviral Expression System overcomes these challenges with efficient vir...
Biology Products: