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Effective cancer immune therapy through order in the blood vessels
Date:4/21/2008

ere surprised that a gene that apparently affects vascular structure has such a strong influence on the success of immune therapies. Rgs5 is, thus, a completely new, promising target structure for clinical tumor therapy, says DKFZs Professor Gnter Hmmerling, one of the scientists leading the study. But we dont necessarily have to knock out Rgs5 to improve the success of immune therapies. Available therapeutics that normalize tumor vasculature should also increase the invasion of immune cells into tumor tissue.

Juliana Hamzah, Manfred Jugold, Fabian Kiessling, Paul Rigby, Mitali Manzur, Hugo H. Marti, Tamer Rabie, Sylvia Kaden, Hermann-Josef Grne, Gnter J. Hmmerling, Bernd Arnold and Ruth Ganss: Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature 2008, DOI: 10.1038/nature06868

The task of the Deutsches Krebsforschungszentrum in Heidelberg (German Cancer Research Center, DKFZ) is to systematically investigate the mechanisms of cancer development and to identify cancer risk factors. The results of this basic research are expected to lead to new approaches in the prevention, diagnosis and treatment of cancer. The Center is financed to 90 percent by the Federal Ministry of Education and Research and to 10 percent by the State of Baden-Wuerttemberg. It is a member of the Helmholtz Association of National Research Centers (Helmholtz-Gemeinschaft Deutscher Forschungszentren e.V.).


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Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

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