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Effect of 6 mT SMF on phagocytosis depends on macrophage differentiation degree
Date:12/3/2010

SMF. The reason being that recruitment of monocytes from the blood could be delayed and thus the rescue of the tissue from inflammation postponed, or a chronic condition could be favored."

Several studies have suggested a potential cause-effect relationship between removal of dead cells and the onset of human pathologies. Indeed, diseases such as LSE, cystic fibrosis, chronic obstructive pulmonary disease (COPD), atherosclerosis, encephalomyelitis autoimmune and multiple sclerosis are correlated to the delayed or inefficient removal of apoptotic cells which can cause persistency of inflammation and tissue damage leading to the onset of immune response. The results obtained in the current study suggest that the exposure to 6 mT SMF affects fluid-phase endocytosis and phagocytosis in monocyte/macrophages in a differentiation degree dependent manner. Thus, even if the underlying biological mechanisms are still for the most part unclear, this work could help to explain the effects of exposure in support of a possible causal relationship between SMF and differentiation degree.

Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "This interesting study by Dini and colleagues suggests the need of thoughtful consideration of the level of Static Magnetic Field exposure that is appropriate for patients bearing a wound and resulting inflammation".


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Contact: Dr. Luciana Dini
Luciana.dini@unisalento.it
Society for Experimental Biology and Medicine
Source:Eurekalert

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