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Effect of 6 mT SMF on phagocytosis depends on macrophage differentiation degree
Date:12/3/2010

tic cells is the cause of several diseases."

The research team studied the effects of 6 mT SMF on the phagocytosis process of differentiating macrophages by using human Kupffer cells, Raw 264,7 macrophages and 12-O-tetradecanoylphorbol-13-acetate [TPA]-differentiated THP-1 monocytes and U937 promonocytes. Indeed, macrophage phagocytosis is the basis of innate immunity and the exposure to Static Magnetic Fields could interfere with a correct immunoresponse. In particular, with this study, the researchers aimed to verify the effect of 6 mT SMF on the phagocytosis mechanism and to compare these effects with those on other internalization processes, like endocytosis.

For many years this research team has focused its interest on the study of the biological effects of SMFs, in particular, moderate intensity (ranging from1 mT to 1 T) SMF that represents the lowest intensity able to interfere with the apoptotic process in relation to apoptotic cell death. Results obtained indicating that [1] SMF significantly influences the phagocytosis of apoptotic cells and latex beads, and to a lesser extent, fluid phase endocytosis and that [2] the effect of SMF is dependent on the degree of macrophage differentiation, validate that the primary site of action of SMF is at the plasma membrane. Indeed, the plasma membrane has a pivotal role in the recognition of apoptotic cells and for their engulfment through connection with the cytoskeleton. 6 mT SMF is able to modify cell surface morphology, distribution of plasma membrane proteins, receptors and sugar residues, and disarrange the cytoskeleton.

Dr Dini said "On the basis of the results obtained in this study in human primary macrophages, even if it is not yet possible to foresee application in medicine, it follows that it is better to avoid exposure of patients bearing a wound, inflammatory foci or abnormal production of apoptotic cells to machinery (including medical equipment) producing moderate intensity
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Contact: Dr. Luciana Dini
Luciana.dini@unisalento.it
Society for Experimental Biology and Medicine
Source:Eurekalert

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