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Effect of 6 mT SMF on phagocytosis depends on macrophage differentiation degree
Date:12/3/2010

The interest in the biological effects of non-ionizing Electro Magnetic Fields (EMFs) and Static Magnetic Fields (SMFs) on the whole organism, as well on cellular systems, has noticeably increased in recent years in consideration of their increased production (from the generation and transmission of electricity, to domestic appliances and industrial equipment, to telecommunications and broadcasting) and the possible health risk for humans. About one century ago, associated with the wide use of electricity, artificial electric and magnetic fields became a part of our living environment. The use of technology in communication, entertainment, industry and science enhanced our quality of life. On the other hand, the biological effects of the electric and magnetic fields associated with this technology are not well understood.

In the work published in the December issue of Experimental Biology and Medicine, Dini and coworkers have incorporated nanotechnology, material science, and the clinical imaging modality MRI, to create a nanosized probe capable of noninvasively visualizing and quantifying the blood vessel growth in tumors in a preclinical model. The work was carried out by Elisa Panzarini, as part of his Post Doctoral research, working together with Luciana Dini and other colleagues, at the University of Salento, Department of Biological and Environmental Science and Technology, Lecce, Italy.

Dr. Dini stated "Taking into account that innate immunity is based on macrophage phagocytosis of non-self microrganisms and particles, the exposure to SMF could interfere with a correct immune response. Indeed, phagocytosis of apoptotic cells represents the end point of apoptosis, allowing the fast removal of dead cells by neighbours and macrophages. For phagocytosis of apoptotic cells to proceed correctly requires the action of a number of genes greater than those involved in the induction of the apoptosis itself. Impaired phagocytosis of apopto
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Contact: Dr. Luciana Dini
Luciana.dini@unisalento.it
Society for Experimental Biology and Medicine
Source:Eurekalert

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