Navigation Links
Economics and evolution help scientists identify new strategy to control antibiotic resistance
Date:3/18/2011

A team of scientists from the University of Oxford, U.K. have taken lessons from Adam Smith and Charles Darwin to devise a new strategy that could one day slow, possibly even prevent, the spread of drug-resistant bacteria. In a new research report published in the March 2011 issue of GENETICS (http://www.genetics.org), the scientists show that bacterial gene mutations that lead to drug resistance come at a biological cost not borne by nonresistant strains. They speculate that by altering the bacterial environment in such a way to make these costs too great to bear, drug-resistant strains would eventually be unable to compete with their nonresistant neighbors and die off.

"Bacteria have evolved resistance to every major class of antibiotics, and new antibiotics are being developed very slowly; prolonging the effectiveness of existing drugs is therefore crucial for our ability to treat infections," said Alex Hall, Ph.D., a researcher involved in the work from the Department of Zoology at the University of Oxford. "Our study shows that concepts and tools from evolutionary biology and genetics can give us a boost in this area by identifying novel ways to control the spread of resistance."

The research team measured the growth rates of resistant and susceptible Pseudomonas aeruginosa bacteria in a wide range of laboratory conditions. They found that the cost of antibiotic resistance has a cost to bacteria, and can be eliminated by adding chemical inhibitors of the enzyme responsible for resistance to the drug. Leveling the playing field increased the ability of resistant bacteria to compete effectively against sensitive strains in the absence of antibiotics. Given that the cost of drug resistance plays an important role in preventing the spread of resistant bacteria, manipulating the cost of resistance may make it possible to prevent resistant bacteria from persisting after the conclusion of antibio
'/>"/>

Contact: Tracey DePellegrin Connelly
td2p@andrew.cmu.edu
412-760-5391
Genetics Society of America
Source:Eurekalert

Page: 1 2

Related biology news :

1. New theory on fairness in economics targets CEO pay
2. TEEB report released on the economics of ecosystems and biodiversity for policy makers
3. Racial differences in breast cancer treatment persist despite similar economics
4. Worm genome offers clues to evolution of parasitism
5. Advance offers revolution in food safety testing
6. Mass extinctions and the evolution of dinosaurs
7. Egalitarian revolution in the Pleistocene?
8. Reproducing early and often is the key to rapid evolution in plants
9. Illuminating biology: An evolutionary perspective
10. Biologists, educators recognize excellence in evolution education
11. Revealing the evolutionary history of threatened sea turtles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... , June 30, 2015 Genisphere ... company as CEO to help further develop Genisphere,s therapeutics ... of partnering experience, having spent much of the last ... Therakine, Amgen, Baxter Bioscience, and Johnson & Johnson. Tom ... on Technology and Biotech Corporate Finance. He graduated from ...
(Date:6/25/2015)... June 25, 2015  TAKE Solutions Ltd., a global ... the United States Patent and Trademark Office (USPTO) for ... leverages TAKE Solutions, Clinical Accelerators to reduce the time ... compared to standardization without the accelerators), thus reducing time ... At the heart of the patented Clinical ...
(Date:6/24/2015)... Biometry authentication provider KeyLemon today announced ... one face in. Logo - ... in, entering the expanding biometric authentication market in ... answer to the password problem. With advanced face ... KeyLemon, one face in allows users to securely ...
Breaking Biology News(10 mins):Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3TAKE Solutions Awarded Patent By USPTO 2KeyLemon Announces Partnership With Biometric Password Solution onefacein 2
... An Arizona State University research team has developed a ... renewable biofuels. The team has programmed a photosynthetic ... their biofuel byproducts--easier and potentially less costly. ... harvesting the goodies and turning them into fuel," said ...
... diffraction is a step closer to fulfilling its ... biological samples. In the Proceedings of the ... in applying an approach to "lensless" X-ray microscopy ... produced the first images, using this technique, of ...
... For more than 400 years, scientists have studied ... how these creatures routinely repair injuries that would usually ... Now, fueled by a highly competitive National Institutes ... multi-institutional team of researchers associated with the University of ...
Cached Biology News:Self-destructing bacteria improve renewable biofuel production 2Self-destructing bacteria improve renewable biofuel production 3Researchers demonstrate nanoscale X-ray imaging of bacterial cells 2$2.4 million stimulus fuels effort to regenerate injured spinal cords 2$2.4 million stimulus fuels effort to regenerate injured spinal cords 3$2.4 million stimulus fuels effort to regenerate injured spinal cords 4
(Date:7/29/2015)... ... July 29, 2015 , ... Finding gooey or crusty material in the corner ... are a considerable number of terms in popular use to describe it, ophthalmologists call ... mixture of mucus, blood cells, skin cells and dust, but until now there has ...
(Date:7/29/2015)... ... July 29, 2015 , ... ... cell culture products, announces the availability of BI’s line of human mesenchymal stem ... these stem cell differentiation media offer a complete system for multipotency evaluation of ...
(Date:7/28/2015)... ... July 29, 2015 , ... Strong Animals™ announced today that research ... operation and presented at the ADSA-ASAS Joint Annual Meeting held July 12-16 in Orlando, ... cows and increased milk fat content. Also, feed containing Stay Strong™ for Dairy Cows ...
(Date:7/28/2015)... , July 28, 2015 Seahorse Bioscience, ... metabolism, is the provider of XF Technology which ... disease research areas. As the links between mitochondrial ... cell metabolism is escalating rapidly.   ... the Nature Publishing Group (NPG) featuring XF Technology, ...
Breaking Biology Technology:What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 2What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 3What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 4Rainbow Scientific, Inc. Announces Availability of Human Mesenchymal Stem Cell Differentiation Media 2Rainbow Scientific, Inc. Announces Availability of Human Mesenchymal Stem Cell Differentiation Media 3Strong Animals™ Announces South Dakota State University Research Demonstrates Stay Strong™ for Dairy Cows Improves Performance and Feed Stability 2XF Technology Used to Demonstrate Feasibility of Stem Cell Regenerative Technique 2XF Technology Used to Demonstrate Feasibility of Stem Cell Regenerative Technique 3
... WI Governor Jim Doyle today announced his "Grow ... of the recommendations is to increase broadband and ... , ,Mike Tye, AT&T regional vice present of ... encouraged by the "Grow Wisconsin" initiative unveiled today ...
... gathered over 100 executives and leaders of Wisconsin's ... preview his new economic growth package. These leaders ... The Wisconsin Technology Council as well many biotechnology ... The message they heard from governor was his ...
... of Patients Compensation Fund could be illegal , ... expressed support yesterday for Gov. Jim Doyles Grow Wisconsin ... expressed support, but takes issue with the provisions for ... strongest criticism for Doyles proposed use of funds from ...
Cached Biology Technology:Governor Gathers Biotech Leaders at his Residence 2Republicans criticize Doyles growth package 2Republicans criticize Doyles growth package 3Republicans criticize Doyles growth package 4
Agarose for baculovirus plaque assays which allow optimal growth of plated insect cells....
BD BaculoGold Max-XP Insect Cell Medium 1 Liter...
Mycoplasma and virus tested...
Edited by I.H. Pawlowitzki, J.H. Edwards and E.A. Thompson (1997) • This volume covers: Linkage in dominant recessive and oligogenic disease, Model free (non-parametric) methods, Tools for gene ...
Biology Products: