Navigation Links
Eating eggs when pregnant affects breast cancer in offspring
Date:12/1/2008

A stunning discovery based on epigenetics (the inheritance of propensities acquired in the womb) reveals that consuming cholinea nutrient found in eggs and other foodsduring pregnancy may significantly affect breast cancer outcomes for a mother's offspring. This finding by a team of biologists at Boston University is the first to link choline consumption during pregnancy to breast cancer. It also is the first to identify possible choline-related genetic changes that affect breast cancer survival rates.

"We've known for a long time that some agents taken by pregnant women, such as diethylstibesterol, have adverse consequences for their daughters," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "But there's an upside. The emerging science of epigenetics has yielded a breakthrough. For the first time, we've learned that we might be able to prevent breast cancer as early as a mother's pregnancy."

The researchers made the discovery in rats by studying females whose mothers were fed varying amounts of choline during pregnancy. Different groups of pregnant rats received diets containing standard amounts of choline, no choline at all, or extra choline. Then the researchers treated the female offspring with a chemical that causes cancer of the mammary gland (breast cancer). Although animals in all groups developed mammary cancer, the daughters of mothers that had received extra choline during pregnancy had slow growing tumors while daughters of mothers that had no choline during pregnancy had fast growing tumors.

"Our study provides additional support for the notion that choline is an important nutrient that has to be considered when dietary guidelines are developed," said Krzysztof Blusztajn, Ph.D., Professor of Pathology at Boston University and the study's senior researcher. "We hope it will be possible to develop nutritional guidelines for pregnant women that ensure the good health of their offspring well into old age."

The researchers also found multiple genetic and molecular changes in the rats' tumors that correlated with survival outcomes. For example, the slow growing tumors in rats had a genetic pattern similar to those seen in breast cancers of women who are considered to have a good prognosis. The fast growing tumors in mice had a pattern of genetic changes similar to those seen in women with a more aggressive disease. The researchers also found evidence that these genetic changes may result from the way that choline affects modifications of the DNA within the mammary gland of fetuses as they develop in the womb.

The National Cancer Institute estimates that there will be more than 184,000 new cases of breast cancer in 2008 and more than 40,000 deaths. Treatments for women suffering from breat cancer range from hormone therapy to surgery.


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Pitt research identifies new target in brain for treating schizophrenia
2. How eating fruit and vegetables can improve cancer patients response to chemotherapy
3. Better beer: College team creating anticancer brew
4. Plant-eating predator to fight superweed is not magic bullet
5. Diversity of plant-eating fishes may be key to recovery of coral reefs
6. New meat-eating dinosaur from Argentina had bird-like breathing system
7. Meat-eating dinosaur from Argentina had bird-like breathing system
8. Commercial aquatic plants offer cost-effective method for treating wastewater
9. New approach to treating cystic fibrosis lung infection shows promise
10. TGen and Washington University researchers discover new approach to treating endometrial cancer
11. Pay attention! Small packages may lead to overeating
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... ALBANY, New York , March 15, 2016 ... a new market report published by Transparency Market Research "Digital ... Growth, Trends and Forecast 2015 - 2023," the global digital ... at US$ 731.9 Mn in 2014 and is forecast to ... to 2023. Growth of micro, small and medium enterprises (MSMEs) ...
(Date:3/11/2016)... http://www.apimages.com ) - --> http://www.apimages.com ) - ... ( http://www.apimages.com ) - Germany . The ... refugee identity cards. DERMALOG will be unveiling this device, and a ... next week.   --> Germany . ... new refugee identity cards. DERMALOG will be unveiling this device, and ...
(Date:3/9/2016)... 2016 This BCC Research report provides an ... RNA Sequencing (RNA Seq) market for the years 2015, ... and reagents, data analysis, and services. Use ... RNA-Sequencing market such as RNA-Sequencing tools and reagents, RNA-Sequencing ... affecting each segment and forecast their market growth, future ...
Breaking Biology News(10 mins):
(Date:5/31/2016)... , ... May 31, 2016 , ... ... markets molecular imaging systems, today announced that their compact PET scanner called ... Imaging) has been selected by the University of Arizona (UA). , PET and ...
(Date:5/27/2016)... ... 2016 , ... NeuMedics Inc. is pleased to announce that CEO Iain Duncan ... June 2, 2016. The session begins at 1:10 PM and Iain will present the ... used as a topical agent and a treatment for ophthalmic complications of diabetes. , ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... PBI-Gordon Corporation ... Turf and Ornamental Products. , In his 15-year career with PBI-Gordon, Dave has served ... Manager, where he was integral in the development and launch of many of PBI-Gordon’s ...
(Date:5/27/2016)... and READING, England ... Indegene ( http://www.indegene.com ), ein führender ... für die Life-Science-Branche, Pharmaunternehmen und Gesundheitsorganisationen, und ... Anbieter von innovativen wissenschaftlichen Support-Services für den ... von IntraScience heute den Ausbau ihrer bestehenden ...
Breaking Biology Technology: