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Eat less or exercise more? Either way leads to more youthful hearts
Date:1/10/2008

Overweight people who lose a moderate amount of weight get an immediate benefit in the form of better heart health, according to a study conducted at Washington University School of Medicine in St. Louis. And the heart improvements happen whether that weight is shed by eating less or exercising more.

"If individuals want to do something that's good for their heart, then my message to them is lose weight by the method they find most tolerable," says the study's senior author Sndor J. Kovcs, Ph.D, M.D., director of the Cardiovascular Biophysics Laboratory and professor of medicine. "They're virtually guaranteed that it will have a salutary effect on their cardiovascular system."

Studying a group of healthy, overweight but not obese, middle-aged men and women, the researchers found that a yearlong regimen of either calorie restriction or exercise increase had positive effects on heart function. Their analysis revealed that heart function was restored to a more youthful state so that during the heart's filling phase (called diastole) it took less time for participants' hearts to relax and fill with blood. The findings will appear in an upcoming issue of the American Journal of Physiology and are now available online.

"As we get older, our tissues become more fibrotic as collagen fibers accumulate," says study co-author John O. Holloszy, M.D., professor of medicine in the Division of Geriatrics and Nutritional Science. "So the arteries and heart muscle stiffen, and the heart doesn't relax as well after contracting. Similar studies that we've conducted with members of the Caloric Restriction with Optimal Nutrition Society (CRONies) show they have heart function resembling much younger people." CRONies voluntarily consume about 25 percent fewer calories than the average American while still maintaining good nutrition.

The scientists used ultrasound imaging (echocardiography) to measure the diastolic or filling phase of the cardiac c
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Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert

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