Navigation Links
Eastman Dental Center awarded $1.6 million to find ways to prevent cavities
Date:10/28/2008

The National Institutes of Health has awarded Eastman Dental Center's Hyun (Michel) Koo, D.D.S, Ph.D., $1.6 million to continue his work on preventing dental caries, the single most prevalent and costly oral infectious disease in the U.S.

Dental caries (decay) results from the interaction of specific bacteria (such as Streptococcus mutans) with dietary sugars. Streptococcus mutans produces polymers, using sucrose to help them, and other pathogens, to cling to tooth surfaces, forming biofilms, known as dental plaque. Basically, once the bacteria are firmly attached on the tooth surface, it creates cavities by eating sugars and then excreting acids that cause dental decay.

To date, Koo's work has focused on finding novel therapeutic substances from natural sources that could prevent bacteria from forming dental biofilm by disrupting the production of polymers, as well as acids. Koo's research team at Eastman Dental Center, part of the University of Rochester Medical Center, has discovered that specific compounds in cranberry and red wine grapes may significantly reduce the ability of bacteria to form plaque and cause cavities.

Most recently, Koo and his team have identified a novel strategy to reduce the development and virulence of dental biofilms and caries by combining two naturally occurring anti-biofilm molecules with fluoride, which is already well known to prevent cavities.

The NIH grant will allow Koo to continue his work analyzing how such combination therapy will affect the ability of bacteria to produce polymers and acids with the goal of preventing dental biofilm before it occurs. Koo will take a multi-disciplinary approach to identify the most effective dosage and the mode of action of this therapeutic approach, which may also reduce the level of fluoride needed.

"By integrating biochemical and molecular techniques with an in vivo model of dental caries, we will better understand how these compounds affect plaque development and expand their potential usefulness to prevent plaque related diseases in humans," Koo said.


'/>"/>

Contact: Karen Black
karen_black@urmc.rochester.edu
585-273-2864
University of Rochester Medical Center
Source:Eurekalert  

Related biology news :

1. Small-scale fishing in Mexico rivals industrial fisheries in accidental turtle deaths
2. Dental chair a possible source of neurotoxic mercury waste
3. NYU dental professor discovers biological clock linking tooth growth to other metabolic processes
4. SAGE-Hindawi launch Journal of Dental Biomechanics
5. Lower your blood pressure, hydrate your skin and reduce dental plaque -- with chocolate?
6. Georgia Tech/Emory Center to study origin of life
7. Woods Hole Research Center to lead undergraduate initiative in the Siberian Arctic
8. $10 million gift to support cutting-edge epigenome center at USC
9. 3 Columbia University Medical Center faculty elected to Institute of Medicine
10. NHGRI funds new Centers for Excellence in Ethical, Legal and Social Implications Research
11. NYUs Center for Genomics & Systems Biology receives $4.4 million NSF grant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Eastman Dental Center awarded $1.6 million to find ways to prevent cavities
(Date:2/3/2017)... SAN ANTONIO , Feb. 3, 2017  Texas Biomedical ... Dr. Larry Schlesinger as the Institute,s ... of Texas Biomed effective May 31, 2017. He is currently ... and Director of the Center for Microbial Interface Biology at ... Dr. Schlesinger as the new President and CEO of Texas ...
(Date:2/2/2017)... , Feb. 2, 2017   TapImmune, Inc. ... immuno-oncology company specializing in the development of innovative ... treatment of cancer and metastatic disease, announced today ... GMP manufacturing of a second clinical lot of ... folate receptor alpha. The manufactured vaccine product will ...
(Date:2/2/2017)... 1, 2017  Central to its deep commitment ... worldwide, The Japan Prize Foundation today announced the ... pushed the envelope in their respective fields of ... scientists are being recognized with the 2017 Japan ... only contribute to the advancement of science and ...
Breaking Biology News(10 mins):
(Date:2/18/2017)... -- Research and Markets has announced the addition of ... their offering. ... The report provides separate comprehensive analytics for the US, ... World. Annual estimates and forecasts are provided for the period 2015 ... markets. Market data and analytics are derived from primary and secondary ...
(Date:2/17/2017)...  If only one in every hundred cells ... to chemotherapy, thousands of cancer cells would remain ... finding these mutations in ever-smaller subpopulations of tumor ... in blood — to guide treatment decisions and ... however, detecting these genetic anomalies may be more ...
(Date:2/16/2017)... ... ... EIT Digital has launched work to develop a new Smart IOT ... to get under way for the framework, which is designed to reduce the use ... to be transferred eventually to other industries that also require efficient IoT and management ...
(Date:2/16/2017)... PARK, Calif. and GREENWICH, ... Capital, a private investment firm focused on venture ... announced the promotion of Josh Richardson , ... focuses on investments in biotechnology companies.  He is ... has played important roles in Longitude,s investments in ...
Breaking Biology Technology: