Navigation Links
Eastman Dental Center awarded $1.6 million to find ways to prevent cavities
Date:10/28/2008

The National Institutes of Health has awarded Eastman Dental Center's Hyun (Michel) Koo, D.D.S, Ph.D., $1.6 million to continue his work on preventing dental caries, the single most prevalent and costly oral infectious disease in the U.S.

Dental caries (decay) results from the interaction of specific bacteria (such as Streptococcus mutans) with dietary sugars. Streptococcus mutans produces polymers, using sucrose to help them, and other pathogens, to cling to tooth surfaces, forming biofilms, known as dental plaque. Basically, once the bacteria are firmly attached on the tooth surface, it creates cavities by eating sugars and then excreting acids that cause dental decay.

To date, Koo's work has focused on finding novel therapeutic substances from natural sources that could prevent bacteria from forming dental biofilm by disrupting the production of polymers, as well as acids. Koo's research team at Eastman Dental Center, part of the University of Rochester Medical Center, has discovered that specific compounds in cranberry and red wine grapes may significantly reduce the ability of bacteria to form plaque and cause cavities.

Most recently, Koo and his team have identified a novel strategy to reduce the development and virulence of dental biofilms and caries by combining two naturally occurring anti-biofilm molecules with fluoride, which is already well known to prevent cavities.

The NIH grant will allow Koo to continue his work analyzing how such combination therapy will affect the ability of bacteria to produce polymers and acids with the goal of preventing dental biofilm before it occurs. Koo will take a multi-disciplinary approach to identify the most effective dosage and the mode of action of this therapeutic approach, which may also reduce the level of fluoride needed.

"By integrating biochemical and molecular techniques with an in vivo model of dental caries, we will better understand how these compounds affect plaque development and expand their potential usefulness to prevent plaque related diseases in humans," Koo said.


'/>"/>

Contact: Karen Black
karen_black@urmc.rochester.edu
585-273-2864
University of Rochester Medical Center
Source:Eurekalert  

Related biology news :

1. Small-scale fishing in Mexico rivals industrial fisheries in accidental turtle deaths
2. Dental chair a possible source of neurotoxic mercury waste
3. NYU dental professor discovers biological clock linking tooth growth to other metabolic processes
4. SAGE-Hindawi launch Journal of Dental Biomechanics
5. Lower your blood pressure, hydrate your skin and reduce dental plaque -- with chocolate?
6. Georgia Tech/Emory Center to study origin of life
7. Woods Hole Research Center to lead undergraduate initiative in the Siberian Arctic
8. $10 million gift to support cutting-edge epigenome center at USC
9. 3 Columbia University Medical Center faculty elected to Institute of Medicine
10. NHGRI funds new Centers for Excellence in Ethical, Legal and Social Implications Research
11. NYUs Center for Genomics & Systems Biology receives $4.4 million NSF grant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Eastman Dental Center awarded $1.6 million to find ways to prevent cavities
(Date:4/11/2017)... , April 11, 2017 No ... but researchers at the New York University Tandon ... of Engineering have found that partial similarities between ... systems used in mobile phones and other electronic ... The vulnerability lies in the fact ...
(Date:4/5/2017)... 2017  The Allen Institute for Cell Science today ... one-of-a-kind portal and dynamic digital window into the human ... first application of deep learning to create predictive models ... and a growing suite of powerful tools. The Allen ... future publicly available resources created and shared by the ...
(Date:4/4/2017)... April 4, 2017   EyeLock LLC , a ... the United States Patent and Trademark Office (USPTO) has ... the linking of an iris image with a face ... represents the company,s 45 th issued patent. ... very timely given the multi-modal biometric capabilities that have ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... (PRWEB) , ... July 17, 2017 , ... ... are characterized by a wide range of overlapping clinical features. The advancement of ... in the field of NDD research and testing. , However, designing a ...
(Date:7/16/2017)... ... July 16, 2017 , ... OHAUS Corporation, a leading worldwide ... its new line of Extreme Environment Shakers today. , Extreme Environment Shakers , ... for optimal cell growth such as cell cultures, solubility studies and extraction procedures. ...
(Date:7/14/2017)... Martinsried, Germany (PRWEB) , ... July 14, 2017 ... ... developed standardized solution for sample preparation of proteins to clean peptides for mass ... Bioruptor® sonication system. , The PreOmics iST Kit is based on proprietary ...
(Date:7/13/2017)... ... July 13, 2017 , ... Frederick’s first ... experienced robust growth in the past year after an intensive restructuring. Under the ... Acceleration Programs and expanded its board of directors to revitalize the organization. As ...
Breaking Biology Technology: