Navigation Links
Early treatment stops epilepsy in its tracks
Date:12/13/2007

New Haven, Conn.Yale School of Medicine researchers have shown for the first time that it is possible to suppress the development of epilepsy in genetically predisposed animalswhich could open the door to treating epilepsy as a preventable disease.

According to the study published this month in Epilepsia, early treatment of epilepsy-prone rats with the anti-convulsant medication ethosuximide before the onset of seizures led to a marked suppression of seizures both later in life and months after treatment stopped.

Current treatments for epilepsy may control seizures, but they do nothing to alter the underlying disease, said Hal Blumenfeld, M.D., associate professor of neurology and lead author of the study. These findings are important because they set the stage for prevention of epilepsy in genetically susceptible people.

Epilepsy is a common neurological disorder that affects about 50 million people worldwide. It is characterized by seizurestemporary loss of consciousness or muscular controlthat are precipitated by abnormal electrical overload on neurons within the brain.

Using a combination of molecular profiling, electroencephalogram (EEG) recordings, and power spectral analysis, Blumenfeld and his colleagues demonstrated that ethosuximide effectively blocked the expression of an epilepsy-associated maladaptive protein within neurons of the brain and reduced the number of seizures in treated animals.

These findings prove that prevention of epilepsy in people is an achievable goal, Blumenfeld said. Strategies for primary prevention of diseases like epilepsy will be increasingly important as genetic prediction of these diseases improves.

He said the results must be confirmed in other animals and with other medications before moving on to human treatment trials.


'/>"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University  
Source:Eurekalert

Page: 1

Related biology news :

1. 60 second test could help early diagnosis of common brain diseases
2. Restless legs syndrome affects nearly 2 percent of US/UK children
3. Bleeding, not inflammation, is major cause of early lung infection death
4. Pig study sheds new light on the colonisation of Europe by early farmers
5. Color contrast is seen by the brain early doors
6. Extra gene copies were enough to make early humans mouths water
7. Was ability to run early mans Achilles heel?
8. New technique can be breakthrough for early cancer diagnosis
9. Yam bean a nearly forgotten crop
10. NIH awards nearly $23M to University of Chicago for translational research
11. Yam bean a nearly forgotten crop
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Early treatment stops epilepsy in its tracks
(Date:4/8/2015)... N.C. , April 8, 2015  Infinisource, ... solutions and services, and Morpho, a leading supplier ... partnership to produce the market,s most advanced biometrically-enabled ... Infinisource,s iSolved NXG time clock is setting a ... and labor data for the small and mid-size ...
(Date:4/2/2015)... , April 2, 2015 ... DERMALOG by far outperforms the strongest competitors, showing ... high accuracy, the system is capable of a ... speed proves up to be ten times faster ... its runner-up performance.      (Photo: ...
(Date:4/2/2015)... 2015 According to preliminary estimates ... somewhat higher than 125 MSEK. This exceeds the guidance ... that revenues for Q1 2015 would be in line ... Q4 2014. The operating result for the first quarter ... interim report will as previously communicated be published on ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Revises Revenues for Q1 2015 2
... Des Moines, Iowa, USA March 18, 2008 A ... of Rwandan rain forest will have a greater range ... of Africas most ambitious forest restoration and ecological research efforts ... Park, said today that a 30-mile (50km) tree corridor will ...
... the United Kingdom and France have identified four ... of Creutzfeldt-Jakob disease. The study, published March 14th ... these subgroups could represent distinct prion strains in ... Prion diseases are transmissible neurodegenerative disorders characterized ...
... Take a deers body, attach a camels head and add ... odd-ball antelope with the enormous schnoz that lives on the isolated ... they are strange-looking due to over-hunting. Now, according to a ... as well. ...
Cached Biology News:Rwanda conservation effort to link isolated chimps to distant forest 2Rwanda conservation effort to link isolated chimps to distant forest 3Asia's odd-ball antelope faces migration crisis 2
(Date:4/30/2015)... 2015 Nitto Avecia, a leading ... increased capacity and production capability to serve biotechnology ... and service fulfillment continues to drive Nitto Avecia ... throughput capacities. , In Fall 2014, ... process equipment at its Milford, MA facility, which ...
(Date:4/30/2015)... (PRWEB) April 30, 2015 Biodata, ... notebook with integrated protocols and specimen management systems, ... solutions and consulting services for life science research, ... of Labguru’s newest feature: chemical structure and reaction ... features for biologists, bio-chemists, and more, the integration ...
(Date:4/30/2015)... , April 30, 2015  Asterias Biotherapeutics, Inc. ... emerging field of regenerative medicine, today announced that it ... Thursday, May 7, 2015 after the close of the ... call and webcast on Thursday, May 7, 2015 at ... the results and recent corporate developments. For ...
(Date:4/30/2015)... 2015 Available in select spas ... , Fleur’s introduces CC CRÈME ... benefits of makeup, skin care and solar protection ... is designed with specific complexion-correcting pigments to instantly ... and a healthy glow. Far more than a ...
Breaking Biology Technology:Biotechnology Manufacturer Nitto Avecia Expands Capacity to Meet Client Demand 2Labguru Integrates ChemAxon's Marvin JS, to Enhance Functionality for Chemists 2Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 2Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 3Fleur’s Introduces CC CRÈME Perfect Skin Solution 2Fleur’s Introduces CC CRÈME Perfect Skin Solution 3
... accuracy: DNA vaccines that home in on DCs are ... develop new vaccines against infectious diseases is DNA vaccination. ... vaccine, the body converts the information in the DNA ... However, current DNA vaccines induce relatively weak immune responses ...
... UK, 6 March 2008 Elsevier, the world-leading ... and services, announced today Hybrid Materials 2009: The ... which will take place in Tours, France, 15-19 ... has experienced a 14% annual growth in published ...
... DNDN ) will release its fourth quarter financial results on,Thursday, March ... PT; 11:00 a.m. ET to review fiscal year 2007 financial results,and ... follows:, Time: 11:00 AM ... March 13, 2008 Dial-in: 1-877-548-7901 (domestic) or +1-719-325-4844 ...
Cached Biology Technology:JCI online early table of contents: March 6, 2008 2JCI online early table of contents: March 6, 2008 3JCI online early table of contents: March 6, 2008 4Hybrid materials: Exciting interdisciplinary field offering future solutions for industry 2-Dendreon to Hold Conference Call on Thursday, March 13, 2008 at 11:00 AM ET- 2
... The ULS cDNA Synthesis and Labeling Kit ... hybridization experiments. First unmodified cDNA is made ... cDNA using an Oligo(dT) primer. Unlike other ... used in the reverse transcription reaction. This ...
... Dot Blot Kits overcome this limitation and ... a wide range in low-density protein array ... They are ideal for performing reverse-phase protein ... for the presence of low abundant antigens. ...
AC input: 50-60 Hz230 V...
... Convenient, easy-to-use kits for arraying ... detection using common lab equipment. DiscoverLight ... analysis of your protein, cell lysate ... format. The kits include specially designed ...
Biology Products: