Navigation Links
Early-stage gene transcription creates access to DNA
Date:10/6/2008

CHESTNUT HILL, MA (October 6, 2008) A gene contained in laboratory yeast has helped an international team of researchers uncover new findings about the process by which protein molecules bind to control sequences in genes in order to initiate gene expression, according to findings reported in the journal Nature.

Previously thought to be inert carriers of the genetic instructions from DNA, so-called non-coding RNAs turn out to reveal a novel mechanism for creating access to DNA required by transcriptional activation proteins for successful gene expression, according to Boston College Biology Professor Charles Hoffman, a co-author of the study with researchers from two Japanese universities.

The team focused on transcription, the first step in gene expression, whereby the blueprint of a cell's DNA is first communicated and paves the way for RNA to deliver their specific pieces of protein-synthesizing genetic coding essentially flicking the switch that activates the gene.

Hoffman and his colleagues examined how the yeast cell senses its cellular environment and makes decisions about whether or not to express a gene, in this case fbp1, which encodes an enzyme. What they found was a preliminary transcription phase with a flurry of switches flicked "on" and then "off" as seen by the synthesis of non-coding RNA before the final "on" switch is tripped.

The non-coding RNAs initiate over one thousand base pairs of nucleotides along the DNA away from the known start site for this gene. The group discovered that the process of transcribing non-coding RNAs is required for the eventual production of the protein-encoding RNA. The transient synthesis of these non-coding RNAs serves to unfurl the tightly wound DNA, essentially loosening the structure to allow for gene expression.

"This is a novel identification of one of the many ways gene expression can be regulated," said Hoffman. "It's a surprising discovery of why there are all these RNA molecules being made in cells that are not protein-encoding molecules. It is in fact the process of making these molecules that leads to the protein-encoding RNAs."

The paper was co-authored by Hoffman and RIKEN Advanced Science Institute scientists Kouji Hirota, Kazuto Kugou, Takehiko Shibata, Kunihiro Ohta and their colleague Tomoichiro Miyoshi at the University of Tokyo.

"I hope this leads others to find similar events occurring on other genes," said Hoffman. "A big part of this kind of work is understanding that there are other potential mechanisms for gene expression."


'/>"/>

Contact: Ed Hayward
ed.hayward@bc.edu
617-552-4826
Boston College
Source:Eurekalert

Related biology news :

1. Cleveland Clinic leading clinical program to improve early-stage lung cancer detection
2. Stowers Institutes Shilatifard Lab identifies new role for factor critical to transcription
3. NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness
4. Research sheds light on the mechanics of gene transcription
5. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
6. MIT creates new material for fuel cells
7. Novel living system recreates predator-prey interaction
8. Using evolution, UW team creates a template for many new therapeutic agents
9. Auto immune response creates barrier to fertility; could be a step in speciation
10. MIT creates 3-D images of living cell
11. Parente Randolph Secures Access to New Corporate Headquarters With BIO-key(R) Biometric Identification
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2016)... England and DE SOTO, Kansas ... , U.S.-based Stroke Detection Plus® to offer Oncimmune,s ... risk assessment and early detection of lung cancer ... large employers, unions and individuals. --> Early ... unions and individuals. --> Oncimmune, a leader ...
(Date:3/2/2016)... March 2, 2016 ... the "Global Biometrics as a Service ... --> http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) has ... Biometrics as a Service Market 2016-2020" ... Research and Markets ( http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) ...
(Date:3/1/2016)... , March 1, 2016  (RSAC Booth #3041) – ... a whopping $118 billion is lost to false positives, ... and inaccurate fraud detection. At the RSA Conference 2016, ... way companies handle authentication by devaluing the data fraudsters ... analytics. --> --> ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... , April 28, 2016 The ... and Brayton Cryocoolers), Service (Technical Support, Product Repairs & ... - Global Forecast to 2022", published by MarketsandMarkets, the ... Billion by 2022, at a CAGR of 7.29% between ... data Tables and 94 Figures spread through 159 Pages ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... hold an open house for regional manufacturers at its Maple Grove, Minnesota technical ... Okuma, Hardinge Group, Chiron and Trumpf. Almost 20 leading suppliers of tooling, ...
(Date:4/27/2016)... 2016 NanoStruck Technologies Inc. ... ( Frankfurt : 8NSK) gibt bekannt, ... 13. August 2015 die Genehmigung von der CNSX ... 200.000.000 Einheiten auf 400.000.000 Einheiten zu erhöhen, um ... wurden 157.900.000 Einheiten mit dem ersten Teil der ...
(Date:4/27/2016)... ... April 27, 2016 , ... A compact PET ... Tomography) and MRI (Magnetic Resonance Imaging) in existing third-party MRI systems. PET and ... in small animal subjects. Simultaneous PET/MRI imaging offers a solution to many challenges ...
Breaking Biology Technology: