Navigation Links
Early role of mitochondria in AD may help explain limitations to current beta amyloid hypothesis
Date:10/13/2010

(NEW YORK, NY, October 13, 2010) Before Alzheimer's patients experience memory loss, the brain's neurons have already suffered harm for years.

A new study in mouse models by researchers at Columbia University Medical Center has found that the brain's mitochondria -- the powerhouses of the cell -- are one of the earliest casualties of the disease. The study, which appeared in the online Early Edition of PNAS, also found that impaired mitochondria then injure the neurons' synapses, which are necessary for normal brain function.

"The damage to synapses is one of the earliest events in Alzheimer's disease, but we haven't been able to work out the events that lead to the damage," says the study's principle investigator, ShiDu Yan, M.D., professor of clinical pathology and cell biology in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain at Columbia University Medical Center. "Our new findings, along with previous research, suggest that mitochondrial changes harm the synapses, and that we may be able to slow down Alzheimer's at a very early stage by improving mitochondrial function."

Drugs that restore mitochondria function may be able to treat Alzheimer's disease in its earliest stages. One potential drug, cyclosporin, is already used in organ transplant and autoimmune patients. Cyclosporin suppresses the immune system, but it also blocks amyloid beta (Aβ) peptides-induced mitochondrial injury, Dr. Yan has found in previous studies (Du et al. Nature Medicine, 2008).

Cyclosporin, however, has too many toxic side effects for long term use in other patients. Dr. Yan is currently trying to alter the chemical structure of the drug to reduce its toxicity and to improve its ability to cross the blood brain barrier but preserve its protective effect on Aβ-mediated toxicity.

Most Alzheimer's researchers initially believed that Aβ peptides caused the disease after aggregating together
'/>"/>

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. JCI online early table of contents: Oct. 11, 2010
2. Study to reveal link between climate and early human evolution
3. Early lung cancer detection
4. Learning to live on land: How some early plants overcame an evolutionary hurdle
5. A chip off the early hominin tooth
6. Male maturity shaped by early nutrition
7. Early cotton planting requires irrigation
8. Girls early puberty linked to unstable environment via insecure attachment in infancy
9. Research heralds potential for early diagnosis of degenerative brain disorders
10. Genomic sequencing of marine sponge published; revealed early genetic complexity and roots of cancer
11. Exposure to early evening sunlight in spring creates teenage night owls
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... to help better identify and treat those with fibromuscular dysplasia ... of medium sized arteries in the body, which can restrict ... In a new report appearing in August 2014 issue of ... that that FMD may not be limited to the arteries ... abnormalities of bones and joints, as well as evidence that ...
(Date:7/31/2014)... was in full fury, raging swiftly from crown to ... of Yosemite National Park in California,s Sierra Nevada in ... began to turn, enacting a case study in the ... large, severe fires. , "When the Rim Fire hit ... been used as a management tool, rather than immediately ...
(Date:7/31/2014)... Most people are familiar with Hibiscus flowers- they ... where they are commonly planted in the landscape. ... - are endangered species. , Only a relatively ... aware of an equally beautiful and intriguing related ... literally "brother of Hibiscus". , Brother of Hibiscus ...
Breaking Biology News(10 mins):Scientists discover biochemical mechanisms contributing to fibromuscular dysplasia 2The Rim Fire 1 year later: A natural experiment in fire ecology and management 2The Rim Fire 1 year later: A natural experiment in fire ecology and management 3The Rim Fire 1 year later: A natural experiment in fire ecology and management 4The Rim Fire 1 year later: A natural experiment in fire ecology and management 5Brother of Hibiscus is found alive and well on Maui 2
... the membrane of human liver cells that aids in cholesterol ... first step in hepatitis C infection, according to research at ... The cholesterol receptor offers a promising new target for anti-viral ... the researchers, whose findings were reported online in advance of ...
... has taken us a step closer to breeding hardier crops ... off attack from parasites. In a paper published in ... of the United States of America (PNAS), the researchers have ... Arabidopsis thaliana , or thale cress, by controlling an ...
... infants are helpless creatures that only blink, eat, cry ... studies indicate infant brains come equipped with knowledge of ... we study infant knowledge of the world by measuring ... Kristy vanMarle, an assistant professor in the Department of ...
Cached Biology News:Entry point for hepatitis C infection identified 2Improving crops from the roots up 2Babies are born with 'intuitive physics' knowledge, says MU researcher 2
(Date:7/31/2014)... North Shore Towers, a luxury co-op community based just ... of the nation’s leading combined heating and power (CHP) systems ... CHP system. The original CHP system had been maintained since ... life of the plant, GI Energy was contracted to replace ... equipment, while maintaining continuous operation of the entire complex. ...
(Date:7/31/2014)... July 31, 2014 Research and Markets ... Genomics Market 2014-2018" report to their offering. ... is the study of the genetic material or genomes ... strong basis for the discovery and development of diagnostic ... or health conditions. Genomics is supported by three major ...
(Date:7/31/2014)... Senomyx , Inc. (NASDAQ: SNMX ... technologies to discover, develop, and commercialize novel flavor ... industries, today reported financial results for the second ... with $33.6 million in cash and highly liquid ... Senomyx achieved another important milestone with the regulatory ...
(Date:7/31/2014)... and SHENZHEN, China , July ... today the purchase of an Irys™System by ... selected BioNano,s platform to enable comprehensive exploration of human ... for various organisms of interest, including those where no ... together to develop new methods for multiplexing on the ...
Breaking Biology Technology:North Shore Towers Partners with GI Energy to Install Turnkey Natural Gas-Fired Combined Heat and Power Plant 2Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 3SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 4SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 5SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 7SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 8SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 9SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 10SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 11SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 12SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 13SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 14SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 15SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 16BioNano Genomics Announces the Purchase of the Irys System by BGI 2BioNano Genomics Announces the Purchase of the Irys System by BGI 3BioNano Genomics Announces the Purchase of the Irys System by BGI 4
... Gene Expression in Mammalian Cells , Use tag-specific antibodies ... Quinn Lu ,Stratagene , , The pCMV-Tag1 vector is ... cells. A target gene inserted into the pCMV-Tag1 vector,can ... ,(N-terminal, C-terminal or internal tagging), the ...
... with StrataPrep ,midiprep ... Jeff Braman ,Stratagene , Plasmid DNA was purified ... kit, a kit based on anion exchange chromatography, ... yields and,purity (as judged by 260-nm to 280-nm ...
... , , , ... , , Anuradha Mehta Donna Driscoll , ... Cleveland, OH , , , ... We chose Stratagenes Human Universal cDNA Library 1 , (HUCL) ...
Cached Biology Technology:An Epitope Tagging Vector for Gene Expression in Mammalian Cells 2An Epitope Tagging Vector for Gene Expression in Mammalian Cells 3An Epitope Tagging Vector for Gene Expression in Mammalian Cells 4An Epitope Tagging Vector for Gene Expression in Mammalian Cells 5An Epitope Tagging Vector for Gene Expression in Mammalian Cells 6Highest Transfection Efficiency of an Endotoxin-Sensitive Mammalian Cell,Line 2Highest Transfection Efficiency of an Endotoxin-Sensitive Mammalian Cell,Line 3Highest Transfection Efficiency of an Endotoxin-Sensitive Mammalian Cell,Line 4Low Abundance cDNA Cloned Using Stratagenes Human Universal , cDNA Library 2Low Abundance cDNA Cloned Using Stratagenes Human Universal , cDNA Library 3Low Abundance cDNA Cloned Using Stratagenes Human Universal , cDNA Library 4Low Abundance cDNA Cloned Using Stratagenes Human Universal , cDNA Library 5Low Abundance cDNA Cloned Using Stratagenes Human Universal , cDNA Library 6
Recombinant Human CCL21/6Ckine (Mucin Stalk Chimera)...
nucleophosmin (nucleolar phosphoprotein B23, numatrin), mRNA...
...
Acrylamide PAGE 40% Solution, 1 l. Category: Electrophoresis Systems & Standards & Reagents, Electrophoresis Standards and Reagents, Gel Casting Chemicals....
Biology Products: