Navigation Links
Early-onset Parkinson's disease linked to genetic deletion
Date:9/9/2013

en clinically diagnosed with Parkinson's disease. For three individuals with the deletion and Parkinson's disease who were deceased, brain tissue was also examined.

"Through a post-mortem examination, we were able to show that all three patients had a loss of neurons that was typical of that seen in Parkinson's disease. The examination also helped to show that the symptoms of Parkinson's disease were not related to side effects of the medications commonly used to treat schizophrenia," added Dr.Rasmus Kiehl, neuropathologist in UHN's Laboratory Medicine Program, who co-authored the report with CAMH graduate student Nancy Butcher. The team also found that Parkinson's disease in 22q11.2 deletion syndrome is associated with abnormal accumulations of protein called Lewy bodies in the brain in some, but not all cases, just as in another genetic form of Parkinson's disease.

The findings highlight the complexity of clinical care when both Parkinson's disease and 22q11.2 deletion syndrome are present. "Our results may inform best practices in the clinic in these cases," said Dr. Bassett, Senior Scientist in CAMH's Campbell Family Mental Health Research Institute.

Because patients with 22q11.2DS who have schizophrenia are often prescribed anti-psychotic medications, they may experience side-effects such as tremors and muscle stiffness, similar to symptoms of Parkinson's disease.

As a result, the researchers found that anti-psychotic use delayed the diagnosis of Parkinson's disease and the opportunity for treatment by up to 10 years.

For people with early-onset Parkinson's disease, who also have other features that could indicate 22q11.2 deletion syndrome, clinical genetic testing for the deletion on chromosome 22 should be considered, the researchers suggest.

"Our discovery that the 22q11.2 deletion syndrome is associated with Parkinson's disease is very exciting," said Dr. Anthony Lang, Director of the Movement Diso
'/>"/>

Contact: Anita Dubey
anita.dubey@camh.ca
416-535-8501 x4932
Centre for Addiction and Mental Health
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A new gene thought to be the cause in early-onset forms of Alzheimers disease
2. Therapy slows onset and progression of Lou Gehrigs disease, study finds
3. Peering into genetic defects, CU scientists discover a new metabolic disease
4. Researchers discover a new pathway in blood vessel inflammation and disease
5. Stomach bacteria switch off human immune defences to cause disease
6. Type 2 diabetes study to examine role amylin plays in disease
7. Gene makes some HIV-infected patients more at risk for fungal disease
8. Unprecedented control of genome editing in flies promises insight into human development, disease
9. Bacterial toxins cause deadly heart disease
10. Institut Pasteur Korea -- DNDi come together for the fight against neglected diseases
11. Canine distemper virus: An emerging disease in rare Amur tigers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ... "Samsung Galaxy S5 - Home Button Synaptics Fingerprint ... http://photos.prnewswire.com/prnh/20130307/600769 ... than the iPhone 5S, Samsung introduces for the ... The Galaxy S5 home button presents ...
(Date:12/17/2014)... 16, 2014 Research and Markets ... the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major trend ... for medical sensors in biomedical applications. Chemical sensors ... and correct diagnosis during surgical procedures. The Global ...
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the ... 2015-2019" report to their offering. ... is the adoption of multimodal biometric systems. Multimodal ... an individual for verification and identification purposes. This ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... Center report that the red panda is the first non-primate ... This unexpected affinity for an artificial sweetener may reflect ... The findings may shed light on how taste ... taste receptors. "The red panda,s unique taste receptor gives ...
... including antioxidant, immunomodulating, and photoprotectant properties. Carotenoid pigments ... colorants, and are responsible for most of their ... coloration in birds has been shown to act ... status of the individual and its ability to ...
... human cells that protect these against viral infections ... their rapid destruction and thus diminishes the cell,s supply. ... virologist Dr. Oliver Keppler demonstrated this mechanism for the ... for a novel treatment strategy. Another important ...
Cached Biology News:Red pandas reveal an unexpected (artificial) sweet tooth 2Red pandas reveal an unexpected (artificial) sweet tooth 3HIV dearms protective protein in cells 2HIV dearms protective protein in cells 3
(Date:12/19/2014)... Lawrence, MA (PRWEB) December 19, 2014 ... flow MRLAFMQ test for the Detection of Aflatoxin M1 ... test to receive independent third party validation. The peer ... Science Unit of the Institute for Agricultural and Fisheries ... Francis Group. , Aflatoxin B1, the most toxic ...
(Date:12/19/2014)... EVANSTON, Ill. , Dec. 19, 2014 ... to develop novel drugs for diseases of the central ... Ph.D., president and chief executive officer, will present at ... Dr. Riedel,s presentation will take place at 3:00 p.m. ... St. Francis in San Francisco, Calif. ...
(Date:12/19/2014)... , Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... today that they have been acquired by Roche (SIX: ... a privately held company that provides a big data ... sequencing (NGS) data for the academic and translational research ... Unit, and will continue to focus on development of ...
(Date:12/19/2014)... 2014 Research and Markets ( ... "Technology Innovations in Smart Fabrics (Technical Insights)" ... http://photos.prnewswire.com/prnh/20130307/600769 The Research ... a detailed assessment on technological advancements and market ... 1. The Smart Fabrics market is ...
Breaking Biology Technology:Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3Technology Innovations in Smart Fabrics (Technical Insights) 2
... , Ambion scientists have engineered a mutant ... production of full-length cDNA. This engineered reverse transcriptase, , ... href="http://www.ambion.com/catalog/CatNum.php?2048">ArrayScript , ... cDNA than wild type RTs, and rivals even the newest engineered RTs on , ...
... Generated From Both mRNA , ... Clustering analysis is commonly used for interpreting microarray data. ... and a method for measuring , similarity between experiments (gene ... are: Hierarchical, K-means and Self-organizing map. In this article, , ...
... Ambion now offers a complete Gene Expression ... From basic data analysis to our Full Service offering, , ... Full Service offering includes , consultation with ... and comprehensive data analysis. Ambion's long history of providing innovative, ...
Cached Biology Technology:ArrayScript RT: Maximize Yields of Full-length cDNA 2ArrayScript RT: Maximize Yields of Full-length cDNA 3Analysis of Microarray Data 2Analysis of Microarray Data 3Analysis of Microarray Data 4Analysis of Microarray Data 5Analysis of Microarray Data 6Analysis of Microarray Data 7Ambion Offers Gene Expression Profiling Service 2Ambion Offers Gene Expression Profiling Service 3
... potential applications for the use of small ... expression via the RNA interference (RNAi) pathway ... and molecular biology fields. siRNA for experimental ... chemically or enzymatically, and then transfected into ...
... (GST) is commonly used as a fusion ... (1). The GSTTag sequence has been reported ... cases the solubility of its fusion partners. ... form, GSTTag fusion proteins can be purified ...
a1-Antitrypsin (human, alpha-1 AT)...
... 7500ce meets the demands of the routine ... performance from reliable, robust and simple to ... power in the most challenging sample matrices ... equally suited to the toughest analytical challenges ...
Biology Products: