Navigation Links
Early-onset Parkinson's disease linked to genetic deletion
Date:9/9/2013

Sept. 9, 2013 Toronto, Canada Scientists at the Centre for Addiction and Mental Health (CAMH) and University Health Network (UHN) have found a new link between early-onset Parkinson's disease and a piece of DNA missing from chromosome 22. The findings help shed new light on the molecular changes that lead to Parkinson's disease.

The study appears online today in JAMA Neurology.

Among people aged 35 to 64 who were missing DNA from a specific part of chromosome 22, the research team found a marked increase in the number of cases of Parkinson's disease, compared to expected rates of Parkinson's disease in the general population from the same age group.

The deletion, which occurs when a person is born with about 50 genes missing on one chromosome 22, is associated with 22q11.2 deletion syndrome. People with this condition may have heart or other birth defects, learning or speech difficulties, and some develop schizophrenia. It occurs in an estimated 1 in 2,000 to 4,000 births, but is believed to be under-diagnosed.

"22q11.2 deletion syndrome has been fairly well studied in childhood and adolescence, but less is known about its effects as people age," said Dr. Anne Bassett, Director of CAMH's Clinical Genetics Research Program and Director of the Dalglish Family Hearts and Minds Clinic at UHN, the world's first clinic dedicated to adults with 22q11.2 deletion syndrome. A few cases of patients with the syndrome who had Parkinson's disease symptoms had been previously reported, which suggested that the two conditions might be linked.

Parkinson's disease is one of the most common neurodegenerative disorders worldwide, typically affecting people over the age of 65. Earlier onset of Parkinson's disease, before age 50, is rare and has been associated with several other genetic changes that are not on chromosome 22.

The researchers studied 159 adults with 22q11.2 deletion syndrome to discover how many had be
'/>"/>

Contact: Anita Dubey
anita.dubey@camh.ca
416-535-8501 x4932
Centre for Addiction and Mental Health
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A new gene thought to be the cause in early-onset forms of Alzheimers disease
2. Therapy slows onset and progression of Lou Gehrigs disease, study finds
3. Peering into genetic defects, CU scientists discover a new metabolic disease
4. Researchers discover a new pathway in blood vessel inflammation and disease
5. Stomach bacteria switch off human immune defences to cause disease
6. Type 2 diabetes study to examine role amylin plays in disease
7. Gene makes some HIV-infected patients more at risk for fungal disease
8. Unprecedented control of genome editing in flies promises insight into human development, disease
9. Bacterial toxins cause deadly heart disease
10. Institut Pasteur Korea -- DNDi come together for the fight against neglected diseases
11. Canine distemper virus: An emerging disease in rare Amur tigers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... MOUNTAIN VIEW, Calif. , Sept. 1, 2015 ... interaction with travelers during airport passenger screening. This ... which the passenger screening process will become unintrusive. ... and pre-clearance based on voluntary background investigations will ... analysis from Frost & Sullivan, Global Airport ...
(Date:8/26/2015)... August 26, 2015 The report "Multi-Factor ... Five Factor), Application (Travel & Immigration, Government, Banking, Defense, ... Forecast to 2020", published by MarketsandMarkets, Multi-Factor Authentication Market ... growing at a CAGR of 17.7% between 2015 and ... F igures spread through 169 P ...
(Date:8/20/2015)... PLEASANTON, Calif. , Aug. 20, 2015 /PRNewswire/ ... focused on consumers that are active and healthy. ... used in the hospital environment to help improve ... released a video from the Wearable Technologies ... MD discussed new applications for wearables in healthcare.    ...
Breaking Biology News(10 mins):The Future of Airport Security: Passenger Screening Transitioning Into an Invisible Process 2The Future of Airport Security: Passenger Screening Transitioning Into an Invisible Process 3The Future of Airport Security: Passenger Screening Transitioning Into an Invisible Process 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3
... presented at IAS build a compelling case for FUZEON ... the newest drugs to give patients facing resistance their ... treatment goal for all people living with HIV. , ... for all triple-class experienced patients. FUZEON combined with the ...
... A computer scientist at Washington University in St. Louis ... genome of a worm and has found 150 genes ... using the software, he and his colleagues have developed ... genes. , Michael Brent, Ph.D., Washington University professor of ...
... lung damage, according to a team of scientists who used ... in lung transplant patients. , Reporting in today's edition of ... University of Texas Medical School at Houston, and colleagues at ... than 1 percent of a certain type of reparative lung ...
Cached Biology News:Newest HIV drugs should be used with FUZEON(R) 2Newest HIV drugs should be used with FUZEON(R) 3Program finds lost genes in nematode genome 2Program finds lost genes in nematode genome 3Candida albicans Genome Fully Annotated 2Candida albicans Genome Fully Annotated 3
(Date:9/2/2015)... -- Research and Markets ( ... PharmaBiotech,s new report "Biomarkers - Technologies, Markets ... This report follows the broad definition of a ... measured and evaluated as an indicator of normal ... responses to a therapeutic intervention. Tests based on ...
(Date:9/2/2015)... 2015 Biovista Inc. is glad ... 2015 BeHEARD science challenge, a global competition hosted by ... access to the latest life science innovations and technologies. ... pathway analytics capability to support Steven Laffoon ... study of Niemann-Pick Disease Type A (NPA), a rare ...
(Date:9/2/2015)... , Sept. 2, 2015 Australian prostate ... a prestigious Australian science prize recognising ,outstanding, science that ... track to globally launch a novel prostate cancer diagnostic ... a high level consortium taking out the peer-reviewed Australian ... Scientific Research. This prize is awarded ...
(Date:9/2/2015)... Israel , September 2, 2015 ... TASE: BOLT) ("BioLight" or the "Company"), a firm ... in ophthalmology and cancer diagnostics, announced today that ... of glaucoma will be delivered at the Ophthalmology ... the European Society of Cataract & Refractive Surgeons ...
Breaking Biology Technology:Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 2Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 3Biovista Sponsors Wylder Nation Foundation's Research on Acid Sphingomyelinase Deficiency 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 3Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 2Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 3
... of researchers has proposed a way to turn the material ... of electrons with a laser "on-off switch". Graphene is ... carbon atoms only one-atom thick, but 200 times stronger than ... than any other known material. It is almost completely transparent, ...
... June 17, 2011 Kendle International Inc. (Nasdaq: ... increased the consideration amount offered for its cash tender ... its $142.5 million aggregate principal amount of outstanding 3.375% ... No. US48880LAA52) (the "Notes").  The consideration for each $1,000.00 ...
... have been proposed for cell-based diagnostics and regenerative medicine ... develop into a desired cell type -- such as ... the clinical potential of these technologies. New research ... of the International Society for Stem Cell Research (ISSCR) ...
Cached Biology Technology:Graphene may gain an 'on-off switch,' adding semiconductor to long list of material's achievements 2Kendle International Inc. Increases Consideration Amount for Tender Offer and Consent Solicitation for Convertible Notes 2Kendle International Inc. Increases Consideration Amount for Tender Offer and Consent Solicitation for Convertible Notes 3Kendle International Inc. Increases Consideration Amount for Tender Offer and Consent Solicitation for Convertible Notes 4Researchers engineer the environment for stem cell development to control differentiation 2Researchers engineer the environment for stem cell development to control differentiation 3
Salmonella typhimurium Immunogen: Heat inactivated bacterial cells of Salmonella typhimurium B Storage: 4 C...
... Streptavidin Sepharose High Performance, 5 ml. ... used in HiTrap Streptavidin columns for ... for packing into Tricorn 5/50 GL, ... larger scale purifications are required.Extremely useful ...
... Clone/PAD: ZMD.366. Immunogen: ... internal region of human SENP1. ... human ~73 kDa SENP1. ... or DYKDDDDK)-HA-tagged-SENP1 transfected Hep2 cell ...
...
Biology Products: