Navigation Links
Early menopause: A genetic mouse model of human primary ovarian insufficiency
Date:8/30/2012

Scientists have established a genetic mouse model for primary ovarian insufficiency (POI), a human condition in which women experience irregular menstrual cycles and reduced fertility, and early exposure to estrogen deficiency.

POI affects approximately one in a hundred women. In most cases of primary ovarian insufficiency, the cause is mysterious, although genetics is known to play a causative role. There are no treatments designed to help preserve fertility. Some women with POI retain some ovarian function and a fraction (5-10 percent) have children after receiving the diagnosis.

Having a mouse model could accelerate research on the causes and mechanisms of POI, and could eventually lead to treatments, says Peng Jin, PhD, associate professor of human genetics at Emory University School of Medicine.

The results were published online recently in the journal Human Molecular Genetics.

The paper was the result of a collaboration between researchers at Emory and the Institute of Zoology, Chinese Academy of Sciences in Beijing. Dahua Chen, PhD, associate director of the State Key Laboratory of Reproductive Biology, is the senior author and postdoctoral fellow Cuiling Lu is the first author. Stephanie Sherman, PhD, professor of human genetics at Emory, is a co-author.

The mouse model builds on research on women who are carriers of a "premutation" for fragile X syndrome, a leading cause of inherited intellectual disability.

The mice have a fragment of a human X chromosome from a fragile X premutation carrier. Other non-genetic mouse models used to study menopause include surgical removal of the ovaries, or exposure of mice to a chemical, 4-vinylcyclohexene diepoxide, which depletes the ovaries.

"While the fragile X premutation is a leading cause of POI, I think this model will be useful and relevant for all women with this condition," Jin says.

Women with the fragile X premutation account
'/>"/>

Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Artificial womb unlocks secrets of early embryo development
2. Mid-Atlantic suburbs can expect an early spring thanks to the heat of the big city
3. An early spring drives butterfly population declines
4. Hazy shades of life on early Earth
5. American Society of Plant Biologists honors early career women scientists
6. Early warning system for seizures could cut false alarms
7. A new gene thought to be the cause in early-onset forms of Alzheimers disease
8. Promising developments in early diagnosis and treatment of mesothelioma
9. Early detection techniques offer hope for improved outcomes in lung cancer patients
10. New study links air pollution and early death in the UK
11. Attendees Save Up To $800 on Boston-area Pharmaceutical and Healthcare Conferences, Early Bird Discounts Expiring April 27
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... , Aug. 6, 2015  Today, U.S. ... visit Crossmatch ™ to learn firsthand how ... protect data. Crossmatch is a world leader in ... and expertise are helping federal agencies and commercial ... security.   "The vast majority of ...
(Date:8/6/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ... today announced collaboration with Microsoft on biometric fingerprint ... leveraged Synaptics, deep expertise in human interface which ... Through stringent testing, Synaptics, advanced image sensing ... Precision TouchPad (PTP) specification empowering OEMs with Windows ...
(Date:8/5/2015)... 2015 Transparency Market Research has ... - Global Industry Analysis, Size, Share, Growth, Trends and ... recognition is forecast to reach US$ 2,671.8 Mn by ... surveillance systems by civil and government agencies. This is ... terrorist activities across the globe that would elevate the ...
Breaking Biology News(10 mins):Rep. Honda to Visit Crossmatch in Redwood City 2Synaptics Chosen for Human Interface Co-Development on Windows 10 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6
... scientific meeting devoted exclusively to osteoporosis and osteoarthritis in 2010. ... ATTENDEES, More than 5000 researchers and clinicians from ... networking event in the field for 2010. Don,t miss this ... will present on the most recent topics in the field, ...
... team of researchers is being recognized for devising a new ... close scrutiny by scientists investigating its role in the communication ... molecules found elsewhere. Last year, the team, led by ... the Texas Tech University Health Science Center School of Medicine, ...
... COLLEGE STATION This time of year, the word "virus" conjures ... goes to great lengths to avoid. But scientists for Texas ... some viruses can be put to work to help us. ... Herman Scholthof, to be published in the January issue of ...
Cached Biology News:World Congress on Osteoporosis 2010 -- IOF WCO-ECCEO10 2Researchers pin down long-elusive protein that's essential to 'life as we know it' 2Researchers pin down long-elusive protein that's essential to 'life as we know it' 3Virus may chauffeur useful 'packages' into plants 2
(Date:9/3/2015)... MA (PRWEB) , ... September 03, 2015 , ... If ... conference in Boston this October, you will also want to sign up for ... Sunday, October 18th. The tour includes a walk through of the (8) chemistry ...
(Date:9/2/2015)... and LIBERTYVILLE, Ill. (PRWEB) , ... ... ... International, a leading provider of regulatory compliance, quality systems, analytical testing, education ... a consulting firm with expertise in medical device products/processes development, design control, ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... with the use of special anti-vascular endothelial growth factor agents given by injection ... currently does not have a scientific protocol for the many millions diagnosed with ...
(Date:9/2/2015)... Research and ... addition of Jain PharmaBiotech,s new report ... to their offering. The scope ... in situ hybridization (FISH), comparative genomic hybridization ... application of nanobiotechnology, microarrays, real-time polymerase chain ...
Breaking Biology Technology:Erlab Invites You to Tour the Largest Installation of Filtered Fume Hoods in the World 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 4NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 5NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 6NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 7StemCell GeneticMed Announces That It Has Started Stem Cell Treatments for Age Related Dry Macular Degeneration (AMG) 2Global Cytogenetics Technologies Study 2015-2025 - Latest Markets and Companies Analysis 2Global Cytogenetics Technologies Study 2015-2025 - Latest Markets and Companies Analysis 3
... , Carsten-Peter Carstens Anna Waesche ,Stratagene , ... ,BL21-Gold cells * called the BL21-CodonPlus ... E. coli argU,ileY, and leuW tRNA genes. This modification ... to express in conventional E. coli,hosts due to the ...
... PCR mutagenesis kit produces a unique , mutational spectrum , ... , , ... Stratagene , , , ... The , GeneMorph PCR , mutagenesis kit ...
... precast gels* eliminate the need to manually pour gels, ... means no more gels,lost to bubbles or leaking.All CastAway ... 60 days from the date of manufacture, with no,detectable ... 32 Preformed Wells , Stratagene adds a new 6% ...
Cached Biology Technology:Codon Bias-Adjusted BL21 Derivatives for Protein Expression 2Codon Bias-Adjusted BL21 Derivatives for Protein Expression 3Codon Bias-Adjusted BL21 Derivatives for Protein Expression 4Codon Bias-Adjusted BL21 Derivatives for Protein Expression 5Codon Bias-Adjusted BL21 Derivatives for Protein Expression 6Codon Bias-Adjusted BL21 Derivatives for Protein Expression 7Randomize Gene Sequences with New PCR Mutagenesis Kit 2Randomize Gene Sequences with New PCR Mutagenesis Kit 3Randomize Gene Sequences with New PCR Mutagenesis Kit 4Randomize Gene Sequences with New PCR Mutagenesis Kit 5Randomize Gene Sequences with New PCR Mutagenesis Kit 6Randomize Gene Sequences with New PCR Mutagenesis Kit 7Randomize Gene Sequences with New PCR Mutagenesis Kit 8Randomize Gene Sequences with New PCR Mutagenesis Kit 9Randomize Gene Sequences with New PCR Mutagenesis Kit 10Randomize Gene Sequences with New PCR Mutagenesis Kit 11Four New CastAway Precast Gels 2
... and Protein G bind specifically to Fc ... and Protein G conjugates are commonly used ... and immunoglobulin subtypes from serum, hybridoma ascites ... fluids. These reagents are also commonly used ...
... The SYS203 is a complete, ... measurement in small samples, as is ... system is designed around Instechs miniature ... of an inch in diameter (3.2 ...
... of human cullin genes (CUL-1, -2, -3, -4a, -4b, ... Cullin-3 is proposed to be a part of E3 ... E and targets it for ubiquitination, which leads to ... of cdk2, which leads the cell to S phase. ...
... Imaging System is the cost-effective solution for ... tailored to common research imaging tasks, MetaVue ... and simple image analysis. Compatibility with ... means that MetaVue has the power to ...
Biology Products: