Navigation Links
Early light refines the brain's circuitry for vision
Date:6/5/2011

ce rewire to distinguish between their eyes.

"For certain functions, the brain wants to keep track of which eye is which," Berson said. Among those functions are the perception of depth and distance.

At a circuit level, the brain keeps signals from the two eyes distinct by segregating their nerve endings into separate regions in the dorsal lateral geniculate nucleus (dLGN), a key waystation on the path to the visual cortex and conscious visual perception. Scientists have long known this sorting-out process depends on waves of activity that spontaneously excite cells in the inner retina. They did not know until now that the waves are influenced by a light-sensitive type of cell called intrinsically photosensitive retinal ganglion cells (ipRGCs).

About a decade ago, a team Berson led at Brown discovered the ipRGCs, which are the first light-sensitive cells to develop in the eye. They reside in the inner retina, the home of retinal cells that send visual information directly to the brain. The outer retina is where the more familiar rods and cones sense light. Early in life, when the brain is segregating nerve endings into distinct regions in the dLGN, the two retinal layers are not connected, so until ipRGCs were discovered there was no reason to believe that light would affect the sorting process.

The new research doesn't say anything definitive about the consequences of light exposure at this stage for eyesight in adults, especially given that some mammals (such as monkeys) experience this developmental stage in utero.

"Whether different animals in nature are exposed to enough light to induce a change in segregation patterns is unclear," Renna said.

But the research shows that light exposure does improve how well the sorting goes, Berson said, and the work advances neuroscientists' understanding of the eye-distinction process, which is widely studied as a model of "activity-driven" neural development.

To
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Harvard scientists see the early cellular cause of dry eye disease for the first time
2. Women who start prenatal vitamins early are less likely to have children with autism
3. Targeted adalimumab treatment can optimize long-term outcomes for patients with early RA
4. JGIs Susannah Tringe receives prestigious $2.5M DOE Early Career Research Award
5. A tale of 2 lakes: One gives early warning signal for ecosystem collapse
6. Early cancer treatment successes lead to CAREER Award for Rafael Davalos
7. Protein adaptation shows that life on early earth lived in a hot, acidic environment
8. Public forum: Japan and early lessons for the nuclear industry
9. Pancreatic Cancer Action Network-AACR Pathway to Leadership Grants awarded to early-career investigators
10. Nearly 1 in 4 postmenopausal women with fractures is obese
11. New technology to improve early detection and prognosis of cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... release is available in German . ... a very few drugs. When treating overdoses, doctors are often ... especially difficult if there is a combination of drugs involved. ... and accidentally swallows his grandmother,s pills? ETH professor Jean-Christophe Leroux ... to find an answer to this question. "The task was ...
(Date:10/16/2014)... Virginia Institute of Marine Science have received a ... to identify the streams and wetlands most vulnerable ... help local governments and citizens conserve these important ... dataset of tidal-marsh observations first gathered by VIMS ... baseline can today,s researchers accurately map the slow ...
(Date:10/16/2014)... thinking on how the bowel lining develops and, in ... cancer starts. , The researchers produced evidence that stem ... that are a feature of the bowel lining, and ... development, a controversial finding as scientists are still divided ... technologies, Dr Chin Wee Tan and Professor Tony Burgess ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3Cryptic clues drive new theory of bowel cancer development 2
... today center for discovery, economic growth engine, innovation hub, ... prepared for the challenges that lie ahead? , Is America ... , People are our greatest asset how do we ... the fiscal crisis on America,s research enterprise? , , ...
... 2012. Researchers from the University of Maryland School of ... bone marrow in mice to help create tissue cells of ... a scientific step they hope may lead to potential new ... Parkinson,s or Alzheimer,s. The research in collaboration with the University ...
... July 3, 2012 Exposure to childhood maltreatment increases ... many negative consequences of these conditions. This new ... University, Canada, provides important insight into one of the ... expanded our previous work on the epigenetic regulation of ...
Cached Biology News:All Things Research 2012 roundtable discussion 2Study results: Adult stem cells from bone marrow 2Highlighting molecular clues to the link between childhood maltreatment and later suicide 2
(Date:10/22/2014)... SC (PRWEB) October 22, 2014 ... of its cardiovascular pharmacogenetics menu, which enables healthcare ... outcomes. With PCLS’s evidence-based results, healthcare providers ... and optimize their therapy, while minimizing risks for ... the U.S., according to the FDA [1] more ...
(Date:10/22/2014)... /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... its Oral Amphotericin B program.  The company recently ... work involving samples from HIV/AIDS patients exposed ... pre clinical studies and regulatory filings to move ... utilizing approximately $700,000 of funding and technological advice ...
(Date:10/22/2014)... DIEGO and HONG KONG ... innovative rare disease therapeutics enterprise, announced today that rare ... the company as vice president, research. Dr. McKew brings ... including key leadership positions at the National Institutes of ... its acquisition by Wyeth). Dr. McKew will lead aTyr,s efforts ...
(Date:10/20/2014)... October 20, 2014 Convey Computer ... a team from Iowa State University won first place ... Using a Convey HC-2ex, the team’s solution achieved the ... faster than the second place finisher. , Experts from ... upon the month long challenge, using a variety of ...
Breaking Biology Technology:PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3
... Indoor spraying with the insecticide bendiocarb has dramatically decreased ... that insecticides remain a potent weapon for fighting malaria ... an entire class of mosquito-killing compounds, according to a ... The American Journal of Tropical Medicine and Hygiene ...
... Texas, Oct. 5, 2011 Luminex Corporation (NASDAQ: ... the National Marrow Donor Program – Be The Match to ... the chances of finding a match for the growing number ... 100 Luminex employees joined the National Marrow Donor Registry in ...
... ANN ARBOR, Mich., Oct. 5, 2011 Adeona Pharmaceuticals, Inc. ... medicines for serious central nervous system diseases, announced today that ... and Chairman, will provide a brief update on its Alzheimer,s ... of four featured companies at the invitation-only event on Tuesday ...
Cached Biology Technology:Scientists determine alternative insecticide dramatically reduces malaria transmission 2Scientists determine alternative insecticide dramatically reduces malaria transmission 3Scientists determine alternative insecticide dramatically reduces malaria transmission 4Luminex Corporation Joins Forces With the National Marrow Donor Program - Be The Match® 2Luminex Corporation Joins Forces With the National Marrow Donor Program - Be The Match® 3Luminex Corporation Joins Forces With the National Marrow Donor Program - Be The Match® 4Adeona CEO to Present at the NYC Medtech Forum 2
... Analysis Note: The kit contains all the ... determination of NADPH-cytochrome c reductase activity in ... microsomes [endoplastic reticulum (ER)]. It has been ... such as liver, kidney, brain, spleen, and ...
... Strain Competent Cell Sets Sets of ... combinations The most common method ... coli is to use chemically competent ... in the laboratory, greater efficiency, reproducibility and ...
The Saturn 2200 answers your GC/MS questions with the CP-3800 GC and the 2000 Series Ion Trap MS! These components create a platform for the worlds most versatile GC and flexible MS. Both deliver une...
... DNA Methylation Kit uses a simplified procedure ... methylation analysis. The kit is based on ... between cytosine and sodium bisulfite where cytosine ... Methylation Kits innovative in-column desulphonation reaction eliminates ...
Biology Products: