Navigation Links
Early-life experience linked to chronic diseases later in life: UBC research
Date:7/14/2009

People's early-life experience sticks with them into adulthood and may render them more susceptible to many of the chronic diseases of aging, according to a new UBC study.

A team led by UBC researchers Gregory Miller and Michael Kobor performed genome-wide profiling in 103 healthy adults aged 25-40 years.

Those who participated in the study were either low or high in early-life socioeconomic circumstances related to income, education and occupation during the first five years of life. But the two groups were similar in socioeconomic status (SES) at the time the genome assessment was performed and also had similar lifestyle practices like smoking and drinking habits.

Their study, to be published in this week's Proceedings of the National Academy of Sciences, shows that among subjects with low early-life socioeconomic circumstances, there was evidence that genes involved with inflammation were selectively "switched-on" at some point. Researchers believe this is because the cells of low-SES individuals were not effectively responding to a hormone called cortisol that usually controls inflammation.

"We've identified some 'biologic residue' of people's early-life experience that sticks with them into adulthood," says Miller, an associate professor in the Department of Psychology and a member of the Brain Research Centre at UBC Hospital.

"The study suggests that experiences get under the skin," says Kobor, an assistant professor in the UBC Department of Medical Genetics and a scientist at the Centre for Molecular Medicine and Therapeutics at the Child & Family Research Institute.

This pattern of responses might contribute to the higher rates of infectious, respiratory, and cardiovascular diseases as well as some forms of cancer among people who grow up in low-SES households, according to the interdisciplinary research team that also includes scientists from the University of California, Los Angeles.

"It seems to be the case that if people are raised in a low socioeconomic family, their immune cells are constantly vigilant for threats from the environment," says Miller. "This is likely to have consequences for their risk for late-life chronic diseases."


'/>"/>

Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Related biology news :

1. Family conditions may affect when girls experience puberty
2. Wild chimpanzees appear not to regularly experience menopause
3. A call to infuse scientific knowledge into the human experience
4. Lead-flapping objects experience less wind resistance than their trailing counterparts
5. Uncultured bacteria found in amniotic fluids of women who experience preterm births
6. Cantabrian cornice has experienced seven cooling and warming phases over past 41,000 years
7. Risk of common vaginal infection linked to preterm birth appears higher for blacks
8. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
9. Protein chatter linked to cancer activation
10. Western diet linked to increased risk of colon cancer recurrence
11. Sugary drinks, not fruit juice, may be linked to insulin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... and BANGALORE, India , April 28, 2016 ... a product subsidiary of Infosys (NYSE: INFY ), ... a global partnership that will provide end customers ... mobile banking and payment services.      (Logo: ... innovation area for financial services, but it also plays a ...
(Date:4/26/2016)... -- Research and Markets has announced the ...  report to their offering.  , ,     (Logo: ... forecast the global multimodal biometrics market to grow ... 2016-2020.  Multimodal biometrics is being implemented ... healthcare, BFSI, transportation, automotive, and government for controlling ...
(Date:4/15/2016)... DUBLIN , April 15, 2016 ... of the,  "Global Gait Biometrics Market 2016-2020,"  report ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait ... CAGR of 13.98% during the period 2016-2020. ... movement angles, which can be used to compute ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... , May 3, 2016  Dr. Thomas ... surgeon in The Woodlands, Texas , ... 24 percent of treated fat cells in just 25-minutes, ... Close to 90 percent of Americans report feeling bothered ... Nonsurgical fat reduction procedures are a growing industry. This ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... ... with its clients in mind, the fresh look and added functionality give the ... “Recent years have seen a dynamic shift in agriculture – from precision farming ...
(Date:4/29/2016)... ... April 29, 2016 , ... Proove Biosciences, Inc ... announce the launch of the Proove Health Foundation . The Foundation is ... promote the use of personalized medicine for tackling the nation’s most-pressing healthcare epidemics. ...
(Date:4/29/2016)... Diego, CA (PRWEB) , ... April 29, 2016 , ... ... Foundation (NSCF) to support the development of a patient-specific stem cell therapy for the ... in the lab of Dr. Jeanne Loring at The Scripps Research Institute in San ...
Breaking Biology Technology: