Navigation Links
Early-life experience linked to chronic diseases later in life: UBC research
Date:7/14/2009

People's early-life experience sticks with them into adulthood and may render them more susceptible to many of the chronic diseases of aging, according to a new UBC study.

A team led by UBC researchers Gregory Miller and Michael Kobor performed genome-wide profiling in 103 healthy adults aged 25-40 years.

Those who participated in the study were either low or high in early-life socioeconomic circumstances related to income, education and occupation during the first five years of life. But the two groups were similar in socioeconomic status (SES) at the time the genome assessment was performed and also had similar lifestyle practices like smoking and drinking habits.

Their study, to be published in this week's Proceedings of the National Academy of Sciences, shows that among subjects with low early-life socioeconomic circumstances, there was evidence that genes involved with inflammation were selectively "switched-on" at some point. Researchers believe this is because the cells of low-SES individuals were not effectively responding to a hormone called cortisol that usually controls inflammation.

"We've identified some 'biologic residue' of people's early-life experience that sticks with them into adulthood," says Miller, an associate professor in the Department of Psychology and a member of the Brain Research Centre at UBC Hospital.

"The study suggests that experiences get under the skin," says Kobor, an assistant professor in the UBC Department of Medical Genetics and a scientist at the Centre for Molecular Medicine and Therapeutics at the Child & Family Research Institute.

This pattern of responses might contribute to the higher rates of infectious, respiratory, and cardiovascular diseases as well as some forms of cancer among people who grow up in low-SES households, according to the interdisciplinary research team that also includes scientists from the University of California, Los Angeles.


'/>"/>
Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Family conditions may affect when girls experience puberty
2. Wild chimpanzees appear not to regularly experience menopause
3. A call to infuse scientific knowledge into the human experience
4. Lead-flapping objects experience less wind resistance than their trailing counterparts
5. Uncultured bacteria found in amniotic fluids of women who experience preterm births
6. Cantabrian cornice has experienced seven cooling and warming phases over past 41,000 years
7. Risk of common vaginal infection linked to preterm birth appears higher for blacks
8. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
9. Protein chatter linked to cancer activation
10. Western diet linked to increased risk of colon cancer recurrence
11. Sugary drinks, not fruit juice, may be linked to insulin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... 30, 2015 To bolster its efforts and commitment ... announced today the addition of two new team members. ... advisor and David Raviv will act as head ... Corp.,s commitment to providing the most secure solutions for the ... co-founded Layer 7 Technologies, a provider of security and management ...
(Date:6/30/2015)... 2015 Genisphere announced Tom ... help further develop Genisphere,s therapeutics capabilities and portfolio. Mr. ... spent much of the last 25 years in leadership ... and Johnson & Johnson. Tom started his career in ... Corporate Finance. He graduated from Dartmouth College with a ...
(Date:6/29/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/zj7h4f/latin_america ) ... Biomedical Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... America Biomedical Sensors market is estimated at $0.65 billion ... period 2014-2020 The near future will bring ... of each individual. These sensors can be set to ...
Breaking Biology News(10 mins):HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3Latin America Biomedical Sensors Market Report 2015-2020 2
... genetic and geographic data of the H5N1 avian flu ... They found that multiple strains of the virus originated ... many of the migration routes through which the strains ... strains develop and migrate, health officials can better limit ...
... hold a key to defeating another implacable foe: HIV. ... a drastically weakened rabies virus to ferry HIV-related proteins ... disease. The early evidence shows that the vaccine ?which ... , Reporting April 1, 2007 in the Journal of ...
... squeaky voices, but now helium is also helping people ... at the University of Alberta in Edmonton, Canada have ... oxygen allowed patients with chronic obstructive pulmonary disease (COPD) ... 245 per cent. COPD is a disease of the ...
Cached Biology News:UCI scientists reconstruct migration of avian flu virus 2Jefferson scientists find rabies-based vaccine could be effective against HIV 2Helium helps patients breathe easier 2
(Date:6/29/2015)... ... June 29, 2015 , ... The StampedeCon 2015 ... for the fourth year in a row, will bring top technology professionals to St. ... at the intersection of data and technology. The event is proudly sponsored by DataStax, ...
(Date:6/29/2015)... NEW YORK , June 29, 2015   For ... of life sciences to assess their overall digital maturity ... to show that these companies are not maturing fast ... the healthcare industry in numerous ways overall and customers ... industries in terms of digital customer engagement.  ...
(Date:6/26/2015)... , June 26, 2015  SeraCare Life ... diagnostics manufacturers, today announced that it has signed ... the National Cancer Institute (NCI), part of the ... and positive controls for cancer assays.  The CRADA ... and accurately quantitate control DNA biosynthetics spiked into ...
(Date:6/26/2015)... 2015 /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") ... nominees listed in the management information circular dated June ... Annual Meeting of Shareholders, held earlier today, June ... following 5 nominees proposed by management were elected ... the Company,s next Annual Meeting of Shareholders or ...
Breaking Biology Technology:StampedeCon Announces 2015 Agenda 2StampedeCon Announces 2015 Agenda 3Results from Digital Maturity Study Show Pharma Lagging 2Results from Digital Maturity Study Show Pharma Lagging 3Results from Digital Maturity Study Show Pharma Lagging 4SeraCare Life Sciences Signs CRADA with NCI to Advance Cancer Diagnostics 2SeraCare Life Sciences Signs CRADA with NCI to Advance Cancer Diagnostics 3iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 2iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 3
... Wis. - Tushaus Computer Services , which ... Millennium Design, Inc., a provider of Apple products and ... PCs and Macs, but also intellectual property and technology ... organizations. Financial terms of the deal were not disclosed. ...
... - The latest piece of the University of ... is in place. With the help of two corporate sponsors, ... fund-raising arm designed to promote technology transfer. , ,The foundation, ... has received $1 million in seed funding from both ...
... It's not too early to gauge the level of ... company formed by Beth Donley and University of ... already is rubbing elbows with interested investors, particularly angels, ... for eventually attracting big dollars from venture capitalists involves ...
Cached Biology Technology:UWM launches research foundation 2UW scientist, former WiCell director found stem cell company 2UW scientist, former WiCell director found stem cell company 3
...
... trays and universal trays make vessel ... Shaking speed: 40 - ... amplitude Clamps for Erlenmeyer ... including Fernbach flasks Hinged ...
... convenient, and efficient Denatured protein concentration following ... spin column to make handling easy. The ... which were electro-eluted in their Denatured condition. ... high binding capacity fo all pH values. ...
In Western blotting antibodies recognize 94 K protein band, which corresponds to S-layer protein...
Biology Products: