Navigation Links
Early isolation linked to enhanced response to cocaine
Date:4/16/2009

hed 21 days of age, they were weaned from their mothers and tested for the psychostimulant response to cocaine as well as for the development of sensitization, a phenomenon characterized by an increase response to the same amount of a drug over time. For 5 days, half of the rats from all groups were injected with saline and the other half with cocaine (15 mg/kg). This was followed by a 7 day drug free period and an additional cocaine injection on day 13. Locomotor activity was measured on days 1, 5 and 13 immediately after injection.

Results

The researchers found that:

  • Rats that were isolated during all three developmental periods, showed a higher locomotor response to cocaine than control rats.
  • The study indicates that the developmental period most susceptible to isolation stress, particularly in males, is the neonatal period, since males isolated as neonates show an increase in the locomotor, and sensitized response to cocaine, compared to male control and to female rats.

Conclusions

This study suggests that isolation during early development alters the brain sensitivity to cocaine, such that when the animal reaches adolescence and is exposed to cocaine, it is more sensitive to the psychostimulant effects of the drug.

These studies contribute to understanding the mechanisms that may lead to greater abuse of drugs during adolescence.

Additional studies are planned.


'/>"/>

Contact: Donna Krupa
dkrupa@the-aps.org
703-967-2751
American Physiological Society
Source:Eurekalert

Page: 1 2

Related biology news :

1. Early administration of antiretroviral therapy can improve survival
2. Compendium of pancreatic cancer biomarkers established as strategic approach to early-detection
3. Novel lung cancer vaccine shows promise in fighting early-stage lung cancer
4. Early family ties: No sponge in the human family tree
5. Two innovative University of Texas at Austin biologists become HHMI Early Career Scientists
6. Two Hutchinson Center researchers named HHMI Early Career Scientists
7. Peter Baumann named Howard Hughes Medical Institute Early Career Scientist
8. Whitehead member Peter Reddien named HHMI Early Career Scientist
9. Deep-sea rocks point to early oxygen on Earth
10. No consistent advantage for planting soybean early
11. Study to evaluate success of parental involvement in early childhood education
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Researchers in France have hit on a novel ... receive the correct and most effective treatment possible., ... the western and developing world. If left untreated, ... to renal failure and other complications. In many ... problem. Clearly a more effective pathological approach to ...
(Date:4/17/2014)... Indiana University researchers have detected new early-warning signs of ... discovery could have far-reaching implications for the diagnosis and ... over 25 million Americans. , "We had not expected ... such early stages," said Ann Elsner, professor and associate ... author of the study. "We set out to study ...
(Date:4/17/2014)... have uncovered a new way the immune system may ... efforts to use immune cells to treat illness. , ... the immunological equivalent of "neighborhood police" specialized squads ... organ, instead of an entire city, the body. , ... Louis have shown that the liver, skin and uterus ...
Breaking Biology News(10 mins):New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3Some immune cells defend only 1 organ 2
... Barbara, CA The Bren School-based authors of a study ... have observed toxicity to marine organisms resulting from exposure to ... toxic under similar conditions. Lead author and assistant research ... both Bren School professors and lead scientists at the ...
... at the University of California, Riverside discovered a tiny fairyfly wasp ... United States until then. Nearly exactly a year later, he ... is well established in the country. Called Gonatocerus ater ... North America from Europe. It lays its eggs inside the ...
... New Rochelle, NY, January 24, 2012The time for commercial development ... and curable with gene therapy deserve access to the technology, ... Wilson, MD, PhD, Editor-in-Chief of Human Gene Therapy ... . Human Gene Therapy and Human Gene ...
Cached Biology News:Nano form of titanium dioxide can be toxic to marine organisms 2Wasp found in upstate New York shows up in Southern California 2Gene therapy is a 'disruptive science' ready for commercial development 2
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. ... Road, Warrington, Pa. , Details: The Hepatitis B ... a cure for hepatitis B and improving the quality of ... Ball on Friday, April 11 at Warrington Country Club in ...
(Date:1/14/2014)... leading provider of strategic communications services to corporations and organizations preparing ... the United States and Europe , ... returning to the firm,s Washington, D.C. office. ... two years of service as Associate Commissioner for the Office of ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest international ... medicinal plants and therapeutic derivatives thereof has endorsed ... and researchers about the challenges of adulterated herb ... ) The Society for Medicinal ...
(Date:1/14/2014)... In recent years, growing suspicion about the pharmaceutical ... and promotion has led to unprecedented levels of public ... about the insidious impact of commercialization of research, has ... the world’s biggest pharmas for illegal marketing activities, allegations ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... Germany will present itself as one of the,world,s ... BIO,International Convention. Under the "Breakthroughs in Regenerative Medicines,in ... into the,latest research results in the area of ... the regulatory framework conditions will be,introduced in a ...
... Corporation (Nasdaq: MATK ) announced that it intends ... 2009 on June 3, 2009, at approximately 4:00 p.m. Eastern ... Martek will conduct a conference call to discuss these results ... call live via webcast by visiting Martek,s web site at ...
... North Carolina And ChinaRESEARCH TRIANGLE PARK, N.C., May ... Health Sciences has signed an agreement with China ... Institute for International Drug Development. Building on strengths ... development, and education, the Institute will help to ...
Cached Biology Technology:BIO International Convention 2009: Research Location Germany Presents Potential in Regenerative Medicine 2The Hamner Institutes Announce Partnership With China Medical City 2The Hamner Institutes Announce Partnership With China Medical City 3
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
Experion StdSens chips are the microfluidic chips used to perform standard-sensitivity RNA analysis (nanogram levels) with the Experion automated electrophoresis system. Each chip has the capacity to...
...
Experion HighSens chips are the microfluidic chips used to perform high-sensitivity RNA analysis (picogram levels) with the Experion automated electrophoresis system. Each chip has the capacity to ru...
Biology Products: