Navigation Links
Early exposure to insecticides gives amphibians higher tolerance later

PITTSBURGH -- Amphibians exposed to insecticides early in lifeeven those not yet hatchedhave a higher tolerance to those same insecticides later in life, according to a recent University of Pittsburgh study.

Published in Evolutionary Applications, the Pitt study found that wood frog populations residing farther from agricultural fields are not very tolerant to a particular type of insecticide, but they can become more tolerant with early exposure.

"This is the first study to show that tadpole tolerance to insecticides can be influenced by exposure to insecticides extremely early on in lifein this case, as early as the embryonic stage," said study principal investigator Rick Relyea, Pitt professor of biological sciences within the Kenneth P. Dietrich School of Arts and Sciences and director of the University's Pymatuning Laboratory of Ecology.

"Amphibian populations are declining worldwide, and pesticides and insecticides are one hypothesized cause," said Jessica Hua, lead author of the paper and a PhD candidate studying biological sciences in Relyea's laboratory. "So this discovery has promising implications for the persistence of amphibian populations."

The Pitt teamwhich also included Nathan Morehouse, Pitt assistant professor of biological sciencesexamined three potential factors that might allow larval wood frogs to have a high tolerance to the insecticide: the concentration of the initial insecticide exposure, the timing of the exposure, and the population's history of exposure. They chose to work with carbaryl, a popular household insecticide that also is used for malaria prevention.

The researchers conducted experiments with both embryos and hatchlings that were collected as newly laid eggs from four Pennsylvania pondstwo near agricultural fields and two farther away. Both embryos and hatchlings from all four environs were first exposed to a low, nonlethal concentration of the insecticide. Later, they exposed the same individuals to a lethal concentration of the insecticide at the tadpole stage and measured the tadpoles' mortality rates over the course of several weeks.

Next, the team wanted to observe whether insecticide tolerance played a role in the frogs' acetylcholinesterase (AChE), a key enzyme in the nervous system of animals. Carbaryl is known to bind itself to this AChE enzyme in frogs, causing their nervous systems to slow. The Pitt team measured the concentration of total tadpole AChE in a sample of tadpole bodies, finding that low exposure levels of carbaryl stimulated the tadpoles to produce greater amounts of the enzymemaking them more tolerant to the insecticide later in life.

The team is now examining whether exposure to an insecticide early in life can make amphibians more tolerant to other insecticides.

"In other words, we are asking if a tolerance to one insecticide can convey cross tolerance to other insecticides that affect the nervous system similarly," said Hua.


Contact: B. Rose Huber
University of Pittsburgh

Related biology news :

1. Antiepileptic drug use while pregnant impacts early child development
2. Early life and in utero factors found to influence testicular function in adulthood
3. Light and nanoprobes detect early signs of infection
4. New data on islet autoantibodies in young children defines early type 1 diabetes development
5. Pearly perfection
6. Herbal extract boosts fruit fly lifespan by nearly 25 percent, UCI study finds
7. NIH awards UCI $10 million to study early-life origins of adolescent mental disorders
8. Early exposure to bisphenol A might damage the enamel of teeth
9. Autism discovery paves way for early blood test and therapeutic options
10. Turning point for early human diets occurred 3.5 million years ago
11. JCI early table of contents for May 24, 2013
Post Your Comments:
(Date:10/29/2015)... , Oct. 29, 2015  Rubicon Genomics, Inc., ... U.S. distribution of its DNA library preparation products, ... Rubicon,s new ThruPLEX Plasma-seq kit. ThruPLEX Plasma-seq has ... preparation of NGS libraries for liquid biopsies--the analysis ... and prognostic applications in cancer and other conditions. ...
(Date:10/29/2015)... , Oct. 29, 2015 Today, ... a partnership with 2XU, a global leader in ... a smart hat with advanced bio-sensing technology. The ... athletes to monitor key biometrics to improve overall ... partnership, the two companies will bring together the most ...
(Date:10/27/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ), the ... has adopted the Synaptics ® ClearPad ® ... its newest flagship smartphones, the Nexus 5X by LG ... --> --> Synaptics works closely ... collaboration in the joint development of next generation technologies. ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... 2015 Researchers at the Broad Institute of ... Research at MIT have engineered changes to the revolutionary ... "off-target" editing errors. The refined technique addresses one of ... editing. Science , Feng Zhang ... approximately 1,400 amino acids that make up the Cas9 ...
(Date:12/1/2015)... , Dec. 1, 2015  The Minnesota High ... of the 2015 Tekne Award in the Small and ... at the Minneapolis Convention Center, ... played a significant role in developing new technologies that ... around the world. Clostridium difficile infection ...
(Date:12/1/2015)... Frederick, MD (PRWEB) , ... December 01, 2015 ... ... management solutions provider, announces that its best selling system laboratory animal colony management ... ezColony® Cloud today, without investing in on-site IT resources., , ...
(Date:12/1/2015)... Dr. Harry Lander , President of Regen, expands his role to ... and recruits five distinguished scientists to join ... expands his role to include serving as ... scientists to join advisory team --> Dr. Harry ... serving as Chief Science Officer and ...
Breaking Biology Technology: