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Early embryos can correct genetic abnormalities during development
Date:7/5/2011

final decision about whether to implant the embryo or discard it.

The findings also have implications outside the field of reproductive medicine. Prof Kearns said: "The applications to other fields are numerous. Based on these results, it is likely that some level of aneuploid mosaicism is extremely common, and possibly a normal part of embryogenesis. A current challenge within stem cell biology is the high rate of acquired aneuploidy that is observed with cell colonies in extended culture. Dissecting the mechanism underlying the normalisation observed in this study in a stem cell system would be highly useful and may be applied to cell-based therapeutic approaches using stem cells. An understanding of such in vitro reparative mechanisms could potentially add to current strategies for gene repair and stem cell transplant therapy. Stem cell therapies have been suggested for a wide swath of medical diseases, ranging from haematological disorders to neurological damage."

Determining the mechanisms that govern the process of genetic normalisation in the developing human embryo is the next stage of research for Dr Brezina and Prof Kearns and their colleagues.


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Contact: Hanna Hanssen
hanna@eshre.eu
32-047-335-3381
European Society of Human Reproduction and Embryology
Source:Eurekalert

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