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Early cancer treatment successes lead to CAREER Award for Rafael Davalos
Date:4/5/2011

up to two centimeters beyond the volume of visible tumor," Davalos explained. Since the electric field dissipates from the electrode, the process gives rise to regions of reversibly electroporated cells outside the ablation zone. These cells may then be more susceptible to the uptake of drugs.

"We propose to assess irreversible electroporation 's capacity to treat infiltrative cells within this reversible zone when combined with chemotherapeutic agents. Treatment of malignant gliomas is also limited by insufficient delivery of drugs due to the blood-brain-barrier. Therefore, this plan will also investigate whether IRE can be applied to mediate blood-brain-barrier disruption to aid in the delivery of chemotherapeutic agents.," Davalos said.

Davalos will use a combination of experiments and modeling on the molecular, cellular, and tissue levels. He believes that the broader impacts of his work will allow the medical community to use this therapy in other pathologies such as cardiac arrhythmias.


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Contact: Lynn A. Nystrom
tansy@vt.edu
540-231-4371
Virginia Tech
Source:Eurekalert  

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