Navigation Links
Early brain activity sheds new light on the neural basis of reading

Most people are expert readers, but it is something of an enigma that our brain can achieve expertise in such a recent cultural invention, which lies at the interface between vision and language. Given that the first alphabetic scripts are thought to have been invented only around four to five thousand years it is unlikely that enough time has elapsed to allow the evolution of specialized parts of the brain for reading. While neuroimaging techniques have made some progress in understanding the neural underpinning of this essentially cultural skill, the exact unfolding of brain activity has remained elusive.

Now, a better understanding of the brain basis of reading has been reported in research published in the open-access, peer-reviewed journal PLoS ONE. The research was led by Piers Cornelissen, Morten Kringelbach, Ian Holliday and Peter Hansen from the Universities of York, Oxford, Aston, and Birmingham UK, and was funded by the Wellcome Trust. The authors showed very early interactions between the vision and language domains during reading, with the speech motor areas of the brain (inferior frontal gyrus) being active at the same time (after a seventh of a second) as the orthographic word-form is being resolved within a brain region called the fusiform gyrus. This finding challenges the conventional view of a temporally serial processing sequence for reading in which letter forms are initially decoded, interact with their phonological and semantic representations, and only then gain access to a speech code.

This finding has a potentially important clinical application in relation to developmental dyslexia (affecting between 15-30 million people in the US alone) and those with acquired reading disabilities through injury or disease. A better understanding of normal reading processes could potentially help these individuals.

The research team used a neuroimaging method called magnetoencephalography (MEG) at Aston University, UK. This is an advanced neuroscientific tool, which offers both excellent temporal (in milliseconds) and spatial (in millimetres) resolution of whole brain activity. Because the researchers were primarily interested in the highly automatized processing of words, they used an implicit task that required participants to monitor the colour of a small red cross and to press a button as soon as the colour changed. This was interspersed with words, consonant strings and faces that were shown for 300 ms, but which were not important to solve the task.

The authors found key differences in the early brain activity of normal adults when they were reading words compared to reading consonant strings and seeing faces. Time-frequency analyses showed a left-lateralized inferior frontal gyrus (pars opercularis) response to words between 100-250 ms in the beta frequency band that was significantly stronger than the response to consonant strings or faces. The left inferior frontal gyrus response to words peaked at ~130 ms. This response was significantly later in time than the left middle occipital gyrus, which peaked at ~115 ms, but not significantly different from the peak response in the left mid fusiform gyrus, which peaked at ~140 ms, at a location coincident with the fMRI-defined visual word form area (VWFA). Significant responses were also detected to words in other parts of the reading network, including the anterior middle temporal gyrus, the left posterior middle temporal gyrus, the angular and supramarginal gyri, and the left superior temporal gyrus.

The left inferior frontal gyrus is located in the front of the brain. This is a key region of the language brain and lesions can lead to the inability to articulate words. In the context of the experiment, the inferior frontal gyrus appears to play a key role integrating the visual and language aspects of reading.

Reading problems are common. Further research could identify whether the present finding of early and specific activity in inferior frontal gyrus are affected in individuals with developmental dyslexia. The present paradigm could eventually provide opportunities for early identification of those at risk.


Contact: Rebecca Walton
Public Library of Science

Related biology news :

1. Early isolation linked to enhanced response to cocaine
2. Early isolation linked to enhanced response to cocaine
3. Early administration of antiretroviral therapy can improve survival
4. Compendium of pancreatic cancer biomarkers established as strategic approach to early-detection
5. Novel lung cancer vaccine shows promise in fighting early-stage lung cancer
6. Early family ties: No sponge in the human family tree
7. Two innovative University of Texas at Austin biologists become HHMI Early Career Scientists
8. Two Hutchinson Center researchers named HHMI Early Career Scientists
9. Peter Baumann named Howard Hughes Medical Institute Early Career Scientist
10. Whitehead member Peter Reddien named HHMI Early Career Scientist
11. Deep-sea rocks point to early oxygen on Earth
Post Your Comments:
(Date:11/17/2015)...  Vigilant Solutions announces today that Mr. Dick ... --> --> Mr. ... partnership at TPG Capital, one of the largest global ... in revenue.  He founded and led TPG,s Operating Group, ... from 1997 to 2013.  In his first role, he ...
(Date:11/16/2015)... Calif. , Nov 16, 2015  Synaptics ... of human interface solutions, today announced expansion of ... TouchView ™ touch controller and display driver ... revolution of smartphones. These new TDDI products add ... TD4100 (HD resolution), TD4302 (WQHD resolution), and TD4322 ...
(Date:11/12/2015)... CAMBRIDGE, Mass. , Nov. 12, 2015 /PRNewswire/ ... Broad Institute of MIT and Harvard for use ... chemical discovery information management tools. The partnership will ... share both biological and chemical research information internally ... tools will be used for managing the Institute,s ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015 /CNW/ - iCo Therapeutics ... today reported financial results for the quarter ended ... expressed in Canadian dollars and presented under International ... United States ," said Andrew Rae ... advancements regarding iCo-008 are not only value enriching ...
(Date:11/24/2015)... RALEIGH, N.C. , Nov. 24, 2015  Clintrax Global, Inc., ... Raleigh, North Carolina , today announced that the company has ... earnings represented a 391% quarter on quarter growth posted for Q3 ... Kingdom and Mexico , with the ... place in December 2015. --> United Kingdom ...
(Date:11/24/2015)... , November 24, 2015 SHPG ) announced ... in the Piper Jaffray 27 th Annual Healthcare Conference in ... 1, 2015, at 8:30 a.m. EST (1:30 p.m. GMT). --> ... Financial Officer, will participate in the Piper Jaffray 27 th ... NY on Tuesday, December 1, 2015, at 8:30 a.m. EST (1:30 ...
(Date:11/24/2015)... SAN FRANCISCO , Nov. 24, 2015 /PRNewswire/ ... today announced that Emily Leproust, Ph.D., Twist Bioscience ... Piper Jaffray Healthcare Conference on December 1, 2015 ... Palace Hotel in New York City. ... . Twist Bioscience is on ...
Breaking Biology Technology: