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ETH Zurich researchers develop antibody test
Date:3/3/2008

tered to such a pad, possible antibodies specifically bind to certain sugar molecules. Dyes then reveal to which GPIs the antibodies have attached themselves.

Help for infants

Thanks to the information obtained from the chip, scientists can produce the specific sugar molecules that the immune system has to recognize. The findings on natural re-sistance subsequently acquired are crucial to developing a sugar-based malaria vaccine. This could prove particularly beneficial to children in malaria-infested regions.

The millions of malaria sufferers are primarily infants under the age of five as only adults develop antibodies against the malaria pathogens sugars. An infants immune system is incapable of recognizing and combating the toxic sugar molecules. Consequently, a new, selective vaccine is now called for. Professor Seeberger states: This evidence is another important step towards finding a malaria vaccine because we now know which antibodies protect adults.


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Contact: Peter Seeberger
seeberger@org.chem.ethz.ch
41-446-332-103
ETH Zurich/Swiss Federal Institute of Technology
Source:Eurekalert

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