Navigation Links
ETH Zurich researchers develop antibody test
Date:3/3/2008

ETH Zurich professor Peter Seeberger has been working on a sugar-based malaria vaccine for years. The new test takes him one important step closer to his goal. The malaria pathogen plasmodium falciparum carries poisonous sugar molecules called GPIs for short on its surface that are able to be individually identified. Professor See-bergers research team is now developing a new method that demonstrates that the malaria pathogens toxic sugar molecules trigger a specific immune reaction in adults.

Antibodies in blood from malaria regions

Tests show that blood samples taken from adults living in areas of Africa where malaria is endemic contain specific antibodies against particular GPIs. While infection is still possible despite the antibodies, the consequences are less serious. The immune system recognizes the poisonous sugar molecules as foreign bodies and blocks their toxic impact. Not living in high-risk areas, Europeans lack the relevant antibodies. As soon as Europeans are infected with malaria, the number of antibodies increases significantly. Subsequently, there is a direct link between the amount of antibodies and protection against the disease.

Inexpensive detection

This insight is thanks to a novel method for detecting antibodies. Faustin Kamena, a post-doc in Professor Seebergers lab, has developed a special chip that can, inexpensively and with minute quantities of blood serum and sugar molecules, determine whether or not someone has formed particular antibodies against various GPIs. To this end, the researchers use the purest possible GPIs. These can be produced synthetically and in large amounts in a laboratory, as the Seeberger team has demonstrated in earlier research.

The new method involves affixing over 64 pads comprising pinpoint dots to glass slides. Every little pad consists of several tiny heaps of different GPIs in varying concentrations. When blood serum is then adminis
'/>"/>

Contact: Peter Seeberger
seeberger@org.chem.ethz.ch
41-446-332-103
ETH Zurich/Swiss Federal Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. ETH Zurich competence center ESC introduces energy strategy
2. New ETH Zurich article published in scientific journal Nature
3. ETH Zurich professor Ari Helenius awarded Benoist Prize
4. Image Solutions, Inc. Acquires Zurich Biostatistics, Inc.
5. Electronic structure of DNA revealed for 1st time by Hebrew University and collaborating researchers
6. Researchers offer new theory for dogfish and skate population outburst on Georges Bank
7. UCLA researchers solve decade-old mystery
8. Rats on islands disrupt ecosystems from land to sea, researchers find
9. Iowa State researchers help piece together the corn genomes first draft
10. U-M researchers release most detailed global study of genetic variation
11. LSU researchers challenge analyses on sustainability of Gulf fisheries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... more effective treatments for cachexia, a profound wasting of ... cancer patients, raising their risk of death, according to ... been tried to reverse the condition, which may cause ... but none have had great success. , Scientists reporting ... Nature , led by Bruce Spiegelman, PhD, demonstrated that ...
(Date:7/11/2014)... the City of Entiat on Tuesday, July 8, 2014. ... grew to over 1,000 acres by evening. Three outbuildings ... investigation by the Washington Department of Natural Resources. The ... in developing fire control strategies and tactics. Other cooperators ... of Natural Resources, (WA DNR), Bureau of Land Management, ...
(Date:7/11/2014)... scientists have set a "mouse TRAP" to capture the ... recent study published in the Journal of Clinical ... technique called TRAP to extract cellular and genetic information ... scientists at the Rockefeller Institute for Medical Research in ... protein-making machinery, or ribosomes, of the cell type of ...
Breaking Biology News(10 mins):Antibody halts cancer-related wasting condition 2Antibody halts cancer-related wasting condition 3
... River in Washington, D.C. is showing multiple benefits from ... improved water clarity have increased the abundance and diversity ... to direct measurements taken during the 18-year field study. ... the lower Potomac has doubled, the area covered by ...
... YORK, Sept. 7 Reportlinker.com announces that a new ... Biomarkers - technologies,markets and companies ... This report follows the broad definition of ... measured and evaluated as an indicator of normal biological ...
... 2009, newly installed photovoltaic (PV) cells world-wide produced a peak ... 5.8 GW was located in Europe. Similarly to previous years, ... of the world,s new solar systems were installed. By the ... (existing and newly installed) was 16 GW, which is about ...
Cached Biology News:Potomac River: 10-fold increase in native submerged vegetation reflects improved water quality 2Reportlinker Adds Biomarkers - technologies, markets and companies 2Reportlinker Adds Biomarkers - technologies, markets and companies 3Reportlinker Adds Biomarkers - technologies, markets and companies 4Reportlinker Adds Biomarkers - technologies, markets and companies 5Reportlinker Adds Biomarkers - technologies, markets and companies 6Reportlinker Adds Biomarkers - technologies, markets and companies 7Reportlinker Adds Biomarkers - technologies, markets and companies 8Reportlinker Adds Biomarkers - technologies, markets and companies 9Reportlinker Adds Biomarkers - technologies, markets and companies 10Reportlinker Adds Biomarkers - technologies, markets and companies 11Reportlinker Adds Biomarkers - technologies, markets and companies 12Reportlinker Adds Biomarkers - technologies, markets and companies 13Reportlinker Adds Biomarkers - technologies, markets and companies 14Reportlinker Adds Biomarkers - technologies, markets and companies 15Reportlinker Adds Biomarkers - technologies, markets and companies 16Reportlinker Adds Biomarkers - technologies, markets and companies 17Reportlinker Adds Biomarkers - technologies, markets and companies 18Reportlinker Adds Biomarkers - technologies, markets and companies 19Reportlinker Adds Biomarkers - technologies, markets and companies 20Three-quarters of new solar systems worldwide were installed in the EU in 2009 2Three-quarters of new solar systems worldwide were installed in the EU in 2009 3
(Date:7/10/2014)... PETERSBURG, Russia , July 10, 2014 ... Russian Federation Dmitry Medvedev , presented ... biopharmaceutical company BIOCAD . The Company is developing ... scope of MabNext project BIOCAD develops a number of ... cancer and autoimmune diseases. The ceremony took place at ...
(Date:7/10/2014)... PROVO, Utah , July 10, 2014 ... genome annotation and interpretation, today announced an ... sequencing (NGS) analytics for Lineagen,s NextStep Dx ... evaluation of neurodevelopmental and neurological disorders, currently ... chromosomal microarray (CMA) testing service used by ...
(Date:7/10/2014)... 2014   Ceres, Inc . (Nasdaq: ... today financial results for the three months ended May ... Ceres reported that the company and its ... growing season in Brazil, which concluded in June, despite ... evaluation areas for part of the growing season. Yields ...
(Date:7/10/2014)... may help in the fight against terrorism with the ... of explosives with the use of light and special ... and Actuators B: Chemical , the researchers describe a ... concentrations as low as 6.3 ppm (parts per million). ... minutes. , "Traditionally explosives detection has involved looking for ...
Breaking Biology Technology:Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Detecting trace amounts of explosives with light 2
... Diagnostics, a leading developer of biofluid-based molecular diagnostic ... the appointment of David Okrongly, Ph.D., as chief ... medical officer, and Sally Bowden, Ph.D., as director ... of cardiothoracic surgery Harvard University and Michael Manyak, ...
... Glioblastoma is one of the most aggressive forms ... tumor, glioblastoma will often infiltrate the surrounding brain tissue, ... chemotherapy or radiation. Likewise, several mouse models of glioblastoma ... a new study, a team led by scientists at ...
... announced today the launch of Curve™ Image Guided Surgery. ... surgery, is unveiling at the Congress of Neurological Surgeons ... of enhancements based on years of feedback from our ... for Brainlab and has helped to produce the ultimate ...
Cached Biology Technology:Exosome Diagnostics Announces Additions to Management and Scientific Advisory Board as Company Expands Clinical Validation Studies in Oncology 2Exosome Diagnostics Announces Additions to Management and Scientific Advisory Board as Company Expands Clinical Validation Studies in Oncology 3Exosome Diagnostics Announces Additions to Management and Scientific Advisory Board as Company Expands Clinical Validation Studies in Oncology 4Exosome Diagnostics Announces Additions to Management and Scientific Advisory Board as Company Expands Clinical Validation Studies in Oncology 5Nanoparticles seek and destroy glioblastoma in mice 2Nanoparticles seek and destroy glioblastoma in mice 3Brainlab Launches Newest Innovation in Image Guided Surgery Technology 2Brainlab Launches Newest Innovation in Image Guided Surgery Technology 3
BI-1 Polyclonal Antibody Storage Temperature: -20C Shipping: gel pack Shelf-Life: 12 months...
... cells of embryonal carcinoma of testis and ovary ... like seminoma. Glandular epithelium of yolk sac tumor ... cells of stomach and acini cells of pancreas ... Epitope: Carbohydrate portion on human embryonal carcinoma ...
... Endothelin-1 (human, porcine) Endogenous potent ... ETA receptor and modulates vascular tonus. ET-1, ... three distinct endothelin genes. ET-2 and ET-3 ... two and six amino acids, respectively. All ...
HP 1 alpha Immunogen: Synthetic peptide between amino acids 1-100 of the human HP 1 alpha protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: