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ERK's got rhythm: Protein that controls cell growth found to cycle in and out of cell nucleus
Date:12/1/2009

ed the model to predict how the oscillations would behave under conditions that kept ERK activated for a prolonged period of time. The model predicted the oscillations would die out if ERK stayed on. When the team performed a biochemical experiment in which they prevented ERK from de-activating, the percentage of cells oscillating dropped off, as the model predicted.

To further explore the biological significance of the ERK cycles, Wiley's group would like to test whether other growth factors cause ERK to oscillate in breast cells and whether different types of cells exhibit the same sort of oscillations. Ultimately, they would like to know if they can tweak the oscillation to see how things change inside the cell.


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Contact: Mary Beckman
mary.beckman@pnl.gov
509-375-3688
DOE/Pacific Northwest National Laboratory
Source:Eurekalert

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