Navigation Links
ERK's got rhythm: Protein that controls cell growth found to cycle in and out of cell nucleus
Date:12/1/2009

the model we came up with," said Wiley. "The oscillations anchored our model in reality."

Round and Round

The meaning of the handful of oscillations found by researchers within cells has been controversial. Calcium levels cycle up and down in nerve cells, but scientists still debate why 20 years after the discovery. The production and destruction of the well-known cancer-related protein p53 continuously cycles, but its purpose is unclear. ERK is one protein in a long chain of command involved in cell growth. Because ERK gets repeatedly activated and deactivated by various proteins, Wiley and colleagues thought it might oscillate.

ERK has a role in human breast tissue, where the molecule epidermal growth factor, or EGF, sends a message from the cell surface to the rest of the cell in a carefully regulated manner that includes ERK. In breast cancer, that chain of command goes awry and cells grow out of control. Cancer drug researchers target players in the chain of command to control that growth.

For that reason, Wiley and his colleagues wanted to better understand EGF's chain of command, also known as its signaling pathway. Most researchers use cancer cells, which are easy to manipulate in culture, but Wiley studied healthy breast tissue to find out what goes on in normal cells. In addition, most research examines the population of cells on average, in which individual differences between cells can get lost. This work watched single cells.

Green Eggs

Researchers know a lot about what activates ERK and what shuts it down in the EGF signaling pathway. To follow ERK, the scientists engineered healthy, cultured breast cells to produce a green-glowing version of the protein. When EGF turns on the signaling pathway, the team verified that the green version of ERK is activated in the same way as the regular version is, by the addition of a chemical group. Other proteins deactivate ERK by removing the chem
'/>"/>

Contact: Mary Beckman
mary.beckman@pnl.gov
509-375-3688
DOE/Pacific Northwest National Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Atomic-level snapshot catches protein motor in action
2. Causative gene of a rare disorder discovered by sequencing only protein-coding regions of genome
3. Saliva proteins change as women age
4. The protein Srebp2 drives cholesterol formation in prion-infected neuronal cells
5. Largest-ever database for liver proteins may lead to treatments for hepatitis
6. Escaped proteins add to hearing loss in elderly, UF researchers find
7. High-throughput genotyping, protein purification featured in Cold Spring Harbor Protocols
8. Moderate amounts of protein per meal found best for building muscle
9. Chemosensitivity of cancer cells depends on their protein dependency
10. Biochemical on-switch could solve protein purification challenge
11. Single-stranded DNA-binding protein is dynamic, critical to DNA repair
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... JOSE, Calif. , Aug. 6, 2015 /PRNewswire/ ... leading developer of human interface solutions, today announced ... TouchPad technologies on Windows 10. Microsoft leveraged Synaptics, ... to the operating system. Through ... drivers are fully certified with Microsoft,s Precision TouchPad ...
(Date:8/5/2015)... The biosensors market is proving highly attractive ... newer sectors, and development of devices resulting in higher ... seen the entry of multiple participants each year with ... (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ) Recent ... Global Biosensors Market ( http://www.frost.com/nee9 ), finds that ...
(Date:8/3/2015)... Synaptics, Inc. (Nasdaq: SYNA ), the ... members of the executive management team will present to ... Leadership Forum on Tuesday, August 11, 2015 at 1:00 ... the Sonnenalp Resort in Vail, CO. ... information. An audio webcast of the event will be ...
Breaking Biology News(10 mins):Synaptics Chosen for Human Interface Co-Development on Windows 10 2Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4
... at the University of Rochester have found that small-bodied ... anti-cancer mechanism that appears to be different from any ... The findings are published in today,s issue of ... cancer in humans because many human cancers originate from ...
... Song-Charng Kong,s Iowa State University laboratory have come a ... combustion engine in 1879. There are fuel injectors ... efficiency, cleaner burning and greater reliability. But ... and all kinds of sensors recording engine cylinder pressure, ...
... for years about why uranium contamination in groundwater continues ... at the south end of the Hanford Site. The ... persists. Now, an innovative system has been ... site and to support future cleanup decisions. The site ...
Cached Biology News:Novel anti-cancer mechanism found in long-lived rodents 2Iowa State engineer works to clean and improve engine performance 2Sophisticated monitoring array to address mystery of uranium plume 2Sophisticated monitoring array to address mystery of uranium plume 3
(Date:8/28/2015)... ... ... launch of FireflySci Inc. (FFS) in early 2015, the company continues to shake up the ... Fonz in a lab coat and Large Marge have been posted on the company’s Facebook ... FireflySci is proud to be the only cuvette manufacturer is the world that has an ...
(Date:8/27/2015)... 27, 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage") ... Biohaven Pharmaceutical Holding Company Limited (Biohaven), announced today ... study of BHV-0223, a glutamate modulating agent. Biohaven ... and recently obtained clearance from the U.S. Food ... testing. Portage holds 54% equity interest in Biohaven, ...
(Date:8/27/2015)... , Aug. 27, 2015 HUYA Bioscience International ... of the Japan Society of HTLV-1, held this week ... The purpose of the Society is to promote research ... development of medical technology and research related to these ... "HUYA is proud to support this prestigious ...
(Date:8/27/2015)... PARK, N.C. , Aug. 27, 2015 /PRNewswire/ ... the decision by FedEx, UPS and The US ... certain biological specimens classified as ,select agents, by ... long history of handling these sensitive shipments. ... of global transportation regulations, trained and certified personnel ...
Breaking Biology Technology:Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4Marken Ensures Safe Transportation Of Select Agents And Toxins 2
... BioStorage Technologies, Inc.,(BST) will serve as the biorepository ... Study, a new landmark longitudinal study of coronary ... of Indianapolis and surrounding areas as study participants ... drugs and diagnostics that allow,doctors to better manage ...
... 23 Tengion Inc., a clinical,stage biotechnology company focused ... it has appointed Mark Stejbach as Vice,President, Marketing and ... marketing, sales, finance, and managed care experience from,both Merck ... very pleased to welcome Mark to the Tengion executive ...
... Delivers Solid Financial Performance While Building for the Future, ... GENZ ) today reported strong sales and profit growth ... commercial and clinical,programs., Revenue increased 25 percent to ... quarter. The increase was driven by,growth across all areas ...
Cached Biology Technology:BioStorage Technologies Serves as Repository for Landmark Study of Coronary Artery Disease 2Tengion Appoints Mark Stejbach Vice President of Marketing & Commercial Planning 2Genzyme Reports Strong Second-Quarter Growth 2Genzyme Reports Strong Second-Quarter Growth 3Genzyme Reports Strong Second-Quarter Growth 4Genzyme Reports Strong Second-Quarter Growth 5Genzyme Reports Strong Second-Quarter Growth 6Genzyme Reports Strong Second-Quarter Growth 7Genzyme Reports Strong Second-Quarter Growth 8Genzyme Reports Strong Second-Quarter Growth 9Genzyme Reports Strong Second-Quarter Growth 10Genzyme Reports Strong Second-Quarter Growth 11Genzyme Reports Strong Second-Quarter Growth 12Genzyme Reports Strong Second-Quarter Growth 13Genzyme Reports Strong Second-Quarter Growth 14Genzyme Reports Strong Second-Quarter Growth 15Genzyme Reports Strong Second-Quarter Growth 16Genzyme Reports Strong Second-Quarter Growth 17
Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selecitivty and potential CNS-Side Effect liabilities of compo...
... Endogens Screening Sets contain the ... develop five colorimetric sandwich ELISA plates ... in 100 l/well of cell culture ... and Detection Antibodies, Recombinant Standard (5 ...
... The organic acid analysis ... of six organic salts; molecular ... 294. This standard is provided ... HPX-87H column and the organic ...
... and size analyzer offering a wide dynamic range. ... in mind. It is comprised of a chemically ... The system is completely computer controlled. The modular ... such as dry or where smaller volumes are ...
Biology Products: