Navigation Links
ERK's got rhythm: Protein that controls cell growth found to cycle in and out of cell nucleus
Date:12/1/2009

RICHLAND, Wash. -- Time-lapsed video of individual breast tissue cells reveals a never-before-seen event in the life of a cell: a protein that cycles between two major compartments in the cell. The results give researchers a more complete view of the internal signals that cause breast tissue cells to grow, events that go awry in cancer and are targets of drug development.

The protein ERK, which helps cells respond to growth factors, travels back and forth between the nucleus, where genes are turned on and off, and the cell proper, where proteins work together to keep the cell functioning. In the video, individual cells pulsate with green light as an engineered fluorescent ERK fills the nucleus, exits and re-enters again in cycles that take about 15 minutes. The researchers don't know if the oscillation affects the activity of other proteins in a regulatory fashion, they report in December 1 issue of Molecular Systems Biology, but find the oscillations to be regular and robust.

"True oscillations in biology are rare," said lead author Steve Wiley, chief biologist at EMSL, located at the Department of Energy's Pacific Northwest National Laboratory. "And that the oscillations of such a major growth regulator could go undiscovered for so long is extremely surprising."

ERK As Anchor

One possible function of the oscillations could be in regulating how ERK interacts with other proteins. Regardless of its biological function, ERK oscillations between compartments represent a new behavior that proteins can exhibit within cells.

Biomedical researchers need an accurate mathematical model in hand to test anti-cancer drugs. Adding ERK oscillations into the model allowed Wiley's group to make better predictions about how breast cells will respond to changes in their environment, such as the presence of growth factors or cancer drugs.

"Current models used in drug development behave very differently from
'/>"/>

Contact: Mary Beckman
mary.beckman@pnl.gov
509-375-3688
DOE/Pacific Northwest National Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Atomic-level snapshot catches protein motor in action
2. Causative gene of a rare disorder discovered by sequencing only protein-coding regions of genome
3. Saliva proteins change as women age
4. The protein Srebp2 drives cholesterol formation in prion-infected neuronal cells
5. Largest-ever database for liver proteins may lead to treatments for hepatitis
6. Escaped proteins add to hearing loss in elderly, UF researchers find
7. High-throughput genotyping, protein purification featured in Cold Spring Harbor Protocols
8. Moderate amounts of protein per meal found best for building muscle
9. Chemosensitivity of cancer cells depends on their protein dependency
10. Biochemical on-switch could solve protein purification challenge
11. Single-stranded DNA-binding protein is dynamic, critical to DNA repair
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces that its Wocket® Smart ... week of May, 2015 and will be fulfilling all ... Gino Pereira , Chief Executive Officer said, ... Wocket® enters the consumer market. We would like to ...
(Date:4/17/2015)... Canada , April 17, 2015 ... growing security concerns, and technological advancement to drive ... until 2020   According ... Saudi Arabia Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems ... is projected to register growth at CAGR of ...
(Date:4/10/2015)... , April 10, 2015 Research ... of the "Security Competitive Profiles - NEC" ... , NEC will continue to supply a ... the market, with a company focus on the development ... Winning opportunities in the Asia-Pacific ...
Breaking Biology News(10 mins):Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NEC Security Competitive Profile 2015 2
... DURHAM, N.C. -- Perhaps judging a man by his ... Duke University researchers, using sophisticated machinery to analyze ... scent, have found that individual males are not only ... about their family tree as well. "We ...
... Cells with irreparable DNA damage normally induce programmed cell ... in tumor cells so that transformed cells are able ... the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have ... cells simply degrade a protein that triggers apoptosis in ...
... Foundation for the Advancement of Military Medicine (HJF) ... Sciences (USU) are holding the first-ever USU-HJF Symposiuma ... discuss current and future advances in military medical ... respective research areas will discuss some of the ...
Cached Biology News:Primate's scent speaks volumes about who he is 2Primate's scent speaks volumes about who he is 3Refusal of suicide order: Why tumor cells become resistant 2
(Date:4/28/2015)... (PRWEB) April 28, 2015 Reproductive endocrinologist ... 1 in 7 couples battling infertility in this country, testified ... position Texas as the first state in the nation to ... donate embryos to couples who desire to receive them. , ... the fact that infertility is one of the few medical ...
(Date:4/27/2015)... Dr. Robert Hanzlik, whose groundbreaking research ... implications for advancing the creation of safer pharmaceuticals, will ... University , the second-largest private, nonprofit university in California. ... professor at the University of Kansas School of Pharmacy ... at 5 p.m. and takes place at National University’s ...
(Date:4/27/2015)... CITY, Kan. , April 27, 2015 /PRNewswire/ ... ), a pet therapeutics company focused on the ... for companion animals, today provided commentary on clinical ... presented during a poster session at the American ... ADXS31-164 is a novel Lm ...
(Date:4/27/2015)...  MT Services LLC, a Lawsuit Settlement News ... U.S. District Judge Joseph Goodwin issued ... meeting in hopes to resolve more than 70,000 ... who are involved in multidistrict litigations under him. ... on for some time, and Judge Goodwin has ...
Breaking Biology Technology:Texas Fertility Center Supports a Groundbreaking HB1145 that Facilitates Embryo Donation in Texas 2Texas Fertility Center Supports a Groundbreaking HB1145 that Facilitates Embryo Donation in Texas 3Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 2Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 3Aratana Therapeutics Comments on ADXS31-164 (AT-014) Study Data Presented During Poster Session at the American Association for Cancer Research (AACR) Annual Meeting 2015 2Transvaginal Mesh Lawsuit News: Another Joint Conference Status Meeting Ordered by Judge to Resolve More than 70K TVM Lawsuits against Several Mesh Manufacturers, Says Lawsuitsettlementnews.com 2Transvaginal Mesh Lawsuit News: Another Joint Conference Status Meeting Ordered by Judge to Resolve More than 70K TVM Lawsuits against Several Mesh Manufacturers, Says Lawsuitsettlementnews.com 3
... of the largest technology expenditures of a business. The ... applications developed in-house with a standardized, integrated system, built ... , ,All this is combined with promises of a ... version of the package is released. The popularity of ...
... realist, and she's telling anyone within ear shot that Wisconsin ... independence. , , Molly Jahn The new dean ... (CALS) at the University of Wisconsin-Madison , Jahn believes ... emerging one - biofuels. , ,She's well aware of criticism ...
... page 417 of the executive budget book outlining the 2007-09 ... is another attempt to apply the state's five percent ... proposed tax, put forth two years after a similar proposal ... is designed to level the playing field for traditional music ...
Cached Biology Technology:Five steps to buying the right package software 2Five steps to buying the right package software 3Five steps to buying the right package software 4Five steps to buying the right package software 5Five steps to buying the right package software 6Five steps to buying the right package software 7UW-Madison dean predicts bio-economy will fuel Wisconsin 2UW-Madison dean predicts bio-economy will fuel Wisconsin 3Doyle wants sales tax applied to digital downloads 2Doyle wants sales tax applied to digital downloads 3
cDNA Size Fractionation Columns offer an efficient and convenient method for size-fractioning double-stranded cDNA....
Self Closing Forceps...
... plus assay system offers the ... Designed for batch-processing systems, Long ... density microplates such as 384-well ... Convenient storage conditions ( 2 ...
... the most comprehensive, cost-effective solution to ... incorporated unprecedented quality into both our ... proven detection chemistries and antibodies that ... protocol. It also includes our competitively ...
Biology Products: