Navigation Links
EMBL scientists develop first fully automated pipeline for multiprotein complex production
Date:5/4/2009

Most cellular processes are carried out by molecular machines that consist of many interacting proteins. These protein complexes lie at the heart of life science research, but they are notoriously hard to study. Their abundance is often too low to extract them directly from cells and generating them with recombinant methods has been a daunting task. A new technology to produce multiprotein complexes, developed by researchers at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, and the Paul Scherrer Institute (PSI) in Villigen, Switzerland, now makes the biologist's life easier.

In a paper published in the current issue of Nature Methods researchers of the groups of Imre Berger at EMBL and Michel Steinmetz at the PSI describe ACEMBL, the first fully automated pipeline for the production of multiprotein complexes. Requiring much less effort and materials, the new pipeline will speed up structural studies of protein complexes and will allow to decipher as yet elusive molecular mechanisms of health and disease.

ACEMBL can produce complexes consisting of different types of components, including protein, RNA and other biomolecules. Currently designed to express proteins in the standard system Escherichium coli, the automated pipeline will in future be adapted for complex production in eukaryotic cells. This will allow the study of even larger, more complicated complexes of human origin, including many promising drug targets. The system has already attracted commercial interest.


'/>"/>

Contact: Anna-Lynn Wegener
wegener@embl.de
49-622-138-7452
European Molecular Biology Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. Neuroscientists discover long-term potentiation in the olfactory bulb
2. March of Dimes awards $250,000 prize to scientists unraveling the causes of muscular dystrophy
3. Scientists shed light on inner workings of human embryonic stem cells
4. Stanford scientists turn adult skin cells into muscle and vice versa
5. Just in time for spring: Scientists find the cellular on and off switch for allergies and asthma
6. Geoscientists meet to discuss Rocky Mountain geology
7. Gladstone scientists identify key factors in heart cell creation
8. Fire is important part of global climate change, report scientists
9. Scientists give a hand(edness) to the search for alien life
10. Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
11. Marine scientists warn of potential for spring, summer red tide outbreak in Gulf of Maine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... , April 6, 2017 Forecasts ... ANPR, Document Readers, by End-Use (Transportation & Logistics, Government ... Oil, Gas & Fossil Generation Facility, Nuclear Power), Industrial, ... Other) Are you looking for a definitive ... ...
(Date:4/5/2017)... Today HYPR Corp. , leading innovator ... of the HYPR platform is officially FIDO® Certified ... architecture that empowers biometric authentication across Fortune 500 enterprises ... over 15 million users across the financial services industry, ... product suites and physical access represent a growing portion ...
(Date:4/4/2017)... NEW YORK , April 4, 2017   ... solutions, today announced that the United States Patent and ... The patent broadly covers the linking of an iris ... the same transaction) and represents the company,s 45 th ... our latest patent is very timely given the multi-modal ...
Breaking Biology News(10 mins):
(Date:7/14/2017)... Martinsried, Germany (PRWEB) , ... July 14, 2017 ... ... developed standardized solution for sample preparation of proteins to clean peptides for mass ... Bioruptor® sonication system. , The PreOmics iST Kit is based on proprietary ...
(Date:7/13/2017)... KANSAS CITY, MISSOURI (PRWEB) , ... July 13, ... ... it has earned URAC accreditation in Specialty Pharmacy. URAC is the independent leader ... Heritage Biologics has demonstrated a comprehensive commitment to quality care, improved processes and ...
(Date:7/13/2017)... , ... July 13, 2017 , ... ... two spectrophotometer calibration standards. Blast forward seven years and now they are ... holmium oxide for wavelength accuracy, and resolution testing. , ...
(Date:7/13/2017)... ... July 13, 2017 , ... ... at Philadelphia’s University City Science Center, Christopher Laing, MRCVS, Ph.D. has been tapped ... Texas. Dr. Laing will become the first Executive Director at the newly ...
Breaking Biology Technology: