Navigation Links
EGFR mutation not prognostic factor in non-small cell lung cancer
Date:1/15/2013

DENVER Recent studies have demonstrated that molecular-targeted agents, such as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), may prolong survival of selected patients based on tumor biomarkers. The presence of mutation in the EGFR gene is known as a predictive marker for the response to treatment. However, whether or not these EGFR mutations are prognostic factors for non-small cell lung cancer (NSCLC) has not been known. A recent study published in the February 2013 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, concludes EGFR mutations are not a prognostic factor in surgically resected patients or patients with recurrence treated with conventional therapies. However, after disease recurrence, administration of EGFR tyrosine kinase inhibitors can prolong survival.

A prognostic marker is a patient characteristic or tumor factor that predicts the patient outcome, independent of the treatment. In the study, researchers retrospectively collected a series of samples from patients who underwent surgery whose EGFR mutations status had been tested, then analyzed patient survival. The patients were seen between June 1998 and February 2010 at the Seoul National University Hospital. And after excluding some patients, researchers analyzed data from 863 patients.

They concluded that although the EGFR mutation is a predictive marker for EGFR TKI response, the presence of EGFR mutation is not a prognostic factor in NSCLC.

The researchers believe, "the clinical observation that patients with EGFR mutation seem to survive longer may be because EGFR mutation is more frequently associated with other significant prognostic factors, such as age, stage, or smoking status. On the basis of our results, the pathologic stage seems to affect the prognosis by influencing the cancer recurrence, and smoking status seems to be the most important prognostic factor f
'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1 2

Related biology news :

1. Will a genetic mutation cause trouble? Ask Spliceman
2. BRG1 mutations confer resistance to hormones in lung cancer
3. Researchers reveal how a single gene mutation leads to uncontrolled obesity
4. Genetic mutation found in familial chronic diarrhea syndrome
5. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
6. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
7. Gene mutation identified as contributor to autism spectrum disorders
8. A single stem cell mutation triggers fibroid tumors
9. Common genetic mutation increases sodium retention, blood pressure
10. UC Davis scientists find new role for P53 genetic mutation -- initiation of prostate cancer
11. Gene mutations cause massive brain asymmetry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 16, 2014  Automation is ... this more evident than at international borders. Over ... document scanners have allowed veteran travelers to self ... Passport Control (APC) Kiosks at an increasing number ... globe. According to Maxine ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced ... India 2015-2019" report to their offering. ... market is the adoption of multimodal biometric systems. ... of an individual for verification and identification purposes. ...
(Date:12/10/2014)... You,ve been here before: you desperately need to sign into ... key or the answer to your secret question. What,s your ... Today, Hoyos Labs , a digital infrastructure security ... an end to the frustration that comes with usernames, passwords ... a user,s smartphone to acquire his or her biometrics to ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... them to find their way around in an environment they ... and fully trained animals can cost over 30,000 Euro. It ... of animal welfare considerations to ensure that guide dogs are ... communication between the blind person and the dog is an ...
... intervertebral discs occupies the intervertebral foramen, and nerve roots ... is reduced, fiber bundles gathered together and interrupted at ... and colleagues from the Second Hospital of Hebei Medical ... tensor tractography to reveal spinal nerve root function. A ...
... steroid hormones to choose growth over defence when their survival ... scientific journal eLife could be used to engineer ... dilemma faced by plants is whether to invest their energy ... from The Sainsbury Laboratory. "Knowing how this is controlled ...
Cached Biology News:Under pressure 2
(Date:12/24/2014)... 2014 Vermillion, Inc. (Nasdaq:   VRML), ... announced today that investors including Oracle Investment Management, ... and several Vermillion directors have agreed to purchase ... common stock and warrants to purchase unregistered shares ... Under the terms of the ...
(Date:12/24/2014)... , Dec. 23, 2014 Sigma-Aldrich ... that the waiting period under the Hart-Scott-Rodino Antitrust ... acquisition expired on December 22, 2014, thereby completing ... requirement for the acquisition of the Company by ... antitrust clearance satisfies another condition to closing the ...
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014 /PRNewswire/ ... study of mazindol in children with attention deficit/hyperactivity disorder ... December 2014 . The paper, titled ... attention deficit/hyperactivity disorder" ( Konofal et al, ... eCollection 2014 ) shows that mazindol might be ...
(Date:12/22/2014)... , Dec. 22, 2014   Synthetic ... developer of pathogen-specific therapies for serious infections ... the microbiome, today announced positive topline safety ... clinical trial of SYN-004, the Company,s investigational ... Clostridium difficile (C. difficile) infection, ...
Breaking Biology Technology:Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5
... majority of economists and corporate executives believe that globalization ... it causes. But there is a substantial difference between ... faire attitude towards how this trend affects businesses, communities ... assistant professor of public policy at Rochester Institute of ...
... care providers, health insurance companies and health care clearing ... because these organizations have to prepare to become compliant ... security regulation. The healthcare organizations that have to comply ... have been adopted by Health and Human Services and ...
... make signing on the virtual line the same as signing ... The Wisconsin Legislature passed a measure that will help ... groups, business groups and contract law attorneys hailed the bills ... bi-partisan measure known as Assembly Bill 755 (AB 755). ...
Cached Biology Technology:Preservation not protectionism 2Preservation not protectionism 3The HIPAA Security Regulation: The Journey to Compliance 2The HIPAA Security Regulation: The Journey to Compliance 3Electronic signatures bill sent to Governor 2
Cell Culture Flask, 175 cm, tissue-culture treated polystyrene, barcoded...
... incubation trays are disposable trays ... antigens that have been blotted ... has eight 10.5 cm x ... strips cut from blotted membrane ...
... the state-of-the-art in permanent mounting media. ... preservation of immunohistochemical organic insoluble substrates ... New Fuchsin, and any other organic ... sections. Clarin can be used for ...
... sophisticated DNA analysis and protein analysis tasks, but ... sequence analysis product. Imagine having the ability to ... performed each time you have a new sequence, ... exactly how your output will look for each ...
Biology Products: