Navigation Links
EGFR mutation not prognostic factor in non-small cell lung cancer
Date:1/15/2013

DENVER Recent studies have demonstrated that molecular-targeted agents, such as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), may prolong survival of selected patients based on tumor biomarkers. The presence of mutation in the EGFR gene is known as a predictive marker for the response to treatment. However, whether or not these EGFR mutations are prognostic factors for non-small cell lung cancer (NSCLC) has not been known. A recent study published in the February 2013 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, concludes EGFR mutations are not a prognostic factor in surgically resected patients or patients with recurrence treated with conventional therapies. However, after disease recurrence, administration of EGFR tyrosine kinase inhibitors can prolong survival.

A prognostic marker is a patient characteristic or tumor factor that predicts the patient outcome, independent of the treatment. In the study, researchers retrospectively collected a series of samples from patients who underwent surgery whose EGFR mutations status had been tested, then analyzed patient survival. The patients were seen between June 1998 and February 2010 at the Seoul National University Hospital. And after excluding some patients, researchers analyzed data from 863 patients.

They concluded that although the EGFR mutation is a predictive marker for EGFR TKI response, the presence of EGFR mutation is not a prognostic factor in NSCLC.

The researchers believe, "the clinical observation that patients with EGFR mutation seem to survive longer may be because EGFR mutation is more frequently associated with other significant prognostic factors, such as age, stage, or smoking status. On the basis of our results, the pathologic stage seems to affect the prognosis by influencing the cancer recurrence, and smoking status seems to be the most important prognostic factor for overall survival."


'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Related biology news :

1. Will a genetic mutation cause trouble? Ask Spliceman
2. BRG1 mutations confer resistance to hormones in lung cancer
3. Researchers reveal how a single gene mutation leads to uncontrolled obesity
4. Genetic mutation found in familial chronic diarrhea syndrome
5. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
6. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
7. Gene mutation identified as contributor to autism spectrum disorders
8. A single stem cell mutation triggers fibroid tumors
9. Common genetic mutation increases sodium retention, blood pressure
10. UC Davis scientists find new role for P53 genetic mutation -- initiation of prostate cancer
11. Gene mutations cause massive brain asymmetry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/8/2016)... ANGELES and MANCHESTER, United Kingdom ... ("BBI"), a developer of innovative sensor-based diagnostic products, today announced ... financed by new and existing investors.  Proceeds from the financing ... SEM Scanner , a hand-held device for detecting early-stage pressure ... Ireland after receiving CE Mark approval. ...
(Date:1/7/2016)... , Jan. 7, 2016 Various factors ... biopharmaceutical products such as biologics and biosimilars. Some ... reduce healthcare expenditure, growing demand for cost-effective alternatives, ... population. Biosimilars are similar versions of their corresponding ... to their quality, safety, and efficacy. The global ...
(Date:1/6/2016)... Calif. , Jan. 6, 2016 ... biometrics market, Frost & Sullivan recognizes MorphoTrak, LLC, ... 2015 North American Frost & Sullivan Company of ... contactless fingerprint scanning technology, Morpho Wave™ , has ... in the fingerprint biometrics market. Morpho Wave ...
Breaking Biology News(10 mins):
(Date:2/3/2016)... Denmark , Feb. 3, 2016 Ascendis ... biotechnology company that applies its innovative TransCon technology to ... present at an upcoming investor conference.Event:2016 Leerink Partners Global ... NY Date:  , Wednesday, February 10, 2016 Time:  ... www.ascendispharma.com . --> An audio webcast ...
(Date:2/3/2016)... ... February 03, 2016 , ... Aerocom, a world-leading supplier ... the North American healthcare market. , Aerocom Healthcare, LLC will be based in ... will provide new pneumatic tube systems or expand existing systems within the U.S. ...
(Date:2/3/2016)... ... February 03, 2016 , ... Resilinc released ... and analyzes nearly 750 unique supply chain notifications and alerts generated by its ... Supply chain risk management practitioners subscribe to the EventWatch service to receive early ...
(Date:2/3/2016)... Buffalo, NY (PRWEB) , ... February 03, 2016 ... ... several new products to aid in the rapid development and ongoing quality control ... the Zika Virus outbreak is extremely high,” Dr. Gregory R. Chiklis, President and ...
Breaking Biology Technology: