Navigation Links
Dyslexia-linked genetic variant decreases midline crossing of auditory pathways

Finnish scientists have found that a rare dyslexia-linked genetic variant of the ROBO1 gene decreases normal crossing of auditory pathways in the human brain. The weaker the expression of the gene is, the more abnormal is the midline crossing. The results link, for the first time, a dyslexia-susceptibility gene to a specific sensory function of the human brain. This collaborative study between Aalto University and University of Helsinki in Finland and the Karolinska Insitutet in Sweden was published in the Journal of Neuroscience.

According to previous animal studies, dysfunction of the Robo1 gene prevents normal midline crossing of neurons during fetal development. Humans with totally dysfunctional ROBO1 gene have not been found. However, dyslexic individuals in a large Finnish family have inherited one poorly functioning copy of the ROBO1 gene. This association between ROBO1 and dyslexia was found already in 2005.

In the present study, the scientists quantified the functional crossing of auditory pathways in ten members of this family, applying a sensitive method based on the recording of weak magnetic fields of the brain (magnetoencephalography, MEG). The functional crossing of auditory pathways was significantly weakened in individuals who carried the dyslexia-linked version of the ROBO1 gene.

Dyslexia is the most common learning disability, affecting roughly 10 per cent of the population in most countries.

Contact: Satu Lamminmki, MD
Aalto University

Page: 1

Related biology news :

1. Body clock receptor linked to diabetes in new genetic study
2. Genetics study reveals how bacteria behind serious childhood disease evolve to evade vaccines
3. Genetic regulation of metabolomic biomarkers - paths to cardiovascular diseases and type 2 diabetes
4. Study pinpoints genetic variation that raises a risk linked to bisphosphonates
5. BU study finds new genetic loci associated with menopause onset
6. Sweeping genetic analysis of rare disease yields common mechanism of hypertension
7. Ambry Genetics Reports Results from Clinical Diagnostic Exomeâ„¢ Testing of Three Patients
8. The power of flowers: Research sprouts a closer look at sunflower genetics
9. Simpler times: Did an earlier genetic molecule predate DNA and RNA?
10. Scientists refute Greenpeace claim that genetically modified corn caused new insect pest
11. Identifying sloth species at a genetic level
Post Your Comments:
Related Image:
Dyslexia-linked genetic variant decreases midline crossing of auditory pathways
(Date:11/2/2015)...  SRI International has been awarded a contract of ... to the National Cancer Institute (NCI) PREVENT Cancer Program ... modern testing and support facilities, and analytical instrumentation to ... studies to evaluate potential cancer prevention drugs. ... Drug Development Program is an NCI-supported pipeline to bring ...
(Date:10/29/2015)... 29, 2015  Rubicon Genomics, Inc., today announced ... of its DNA library preparation products, including the ... ThruPLEX Plasma-seq kit. ThruPLEX Plasma-seq has been optimized ... NGS libraries for liquid biopsies--the analysis of cell-free ... applications in cancer and other conditions. Eurofins Scientific ...
(Date:10/27/2015)... NEW YORK , Oct. 27, 2015 ... the major issues of concern for various industry verticals ... This is due to the growing demand for secure ... practices in various ,sectors, such as hacking of bank ... concerns for electronic equipment such as PC,s, laptops, and ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... Zenith Epigenetics Corp. ("Zenith" or the "Company") today announced that ... its Board of Directors to replace Dr. Peter Johann ... experience as co-founder of Resverlogix, with expertise in the fields ... --> Dr. Wong remarked, "I am very excited ... standing expertise in epigenetics and the advanced stage of the ...
(Date:11/30/2015)... , November 30, 2015 TapImmune, ... the development of innovative peptide and gene-based immunotherapeutics and ... today announced it will be presenting at the 8 ... 1, 2015 at 2.30 PM PT. Dr. John ... Advisor will be giving the presentation and will join ...
(Date:11/30/2015)... BETHESDA, Md. , Nov. 30, 2015  Northwest ... biotechnology company developing DCVax® personalized immune therapies for solid ... to adding an additional independent director, and the Company ... investigation of allegations in a recent anonymous internet report ... on both initiatives. Linda Powers stated, ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... includes over 2,000 technical presentations offered in symposia, oral sessions, workshops, awards, and ... covers a wide range of applications such as, but not limited to, biotechnology, ...
Breaking Biology Technology: