Navigation Links
Dyslexia-linked genetic variant decreases midline crossing of auditory pathways
Date:2/1/2012

Finnish scientists have found that a rare dyslexia-linked genetic variant of the ROBO1 gene decreases normal crossing of auditory pathways in the human brain. The weaker the expression of the gene is, the more abnormal is the midline crossing. The results link, for the first time, a dyslexia-susceptibility gene to a specific sensory function of the human brain. This collaborative study between Aalto University and University of Helsinki in Finland and the Karolinska Insitutet in Sweden was published in the Journal of Neuroscience.

According to previous animal studies, dysfunction of the Robo1 gene prevents normal midline crossing of neurons during fetal development. Humans with totally dysfunctional ROBO1 gene have not been found. However, dyslexic individuals in a large Finnish family have inherited one poorly functioning copy of the ROBO1 gene. This association between ROBO1 and dyslexia was found already in 2005.

In the present study, the scientists quantified the functional crossing of auditory pathways in ten members of this family, applying a sensitive method based on the recording of weak magnetic fields of the brain (magnetoencephalography, MEG). The functional crossing of auditory pathways was significantly weakened in individuals who carried the dyslexia-linked version of the ROBO1 gene.

Dyslexia is the most common learning disability, affecting roughly 10 per cent of the population in most countries.


'/>"/>
Contact: Satu Lamminmki, MD
satu.lamminmaki@aalto.fi
358-503-442-818
Aalto University
Source:Eurekalert  

Page: 1

Related biology news :

1. Body clock receptor linked to diabetes in new genetic study
2. Genetics study reveals how bacteria behind serious childhood disease evolve to evade vaccines
3. Genetic regulation of metabolomic biomarkers - paths to cardiovascular diseases and type 2 diabetes
4. Study pinpoints genetic variation that raises a risk linked to bisphosphonates
5. BU study finds new genetic loci associated with menopause onset
6. Sweeping genetic analysis of rare disease yields common mechanism of hypertension
7. Ambry Genetics Reports Results from Clinical Diagnostic Exome™ Testing of Three Patients
8. The power of flowers: Research sprouts a closer look at sunflower genetics
9. Simpler times: Did an earlier genetic molecule predate DNA and RNA?
10. Scientists refute Greenpeace claim that genetically modified corn caused new insect pest
11. Identifying sloth species at a genetic level
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Dyslexia-linked genetic variant decreases midline crossing of auditory pathways
(Date:3/30/2017)... March 30, 2017 The research team of ... three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae ... realm of speed and accuracy for use in identification, crime investigation, ... cost. ... A research ...
(Date:3/29/2017)... 2017  higi, the health IT company that operates ... America , today announced a Series B investment ... EveryMove. The new investment and acquisition accelerates higi,s strategy ... transform population health activities through the collection and workflow ... higi collects and secures data today on behalf of ...
(Date:3/27/2017)... March 27, 2017  Catholic Health Services (CHS) ... Systems Society (HIMSS) Analytics for achieving Stage 6 ... sm . In addition, CHS previously earned a ... using an electronic medical record (EMR). ... level of EMR usage in an outpatient setting.  ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... (PRWEB) , ... October 09, ... ... published on October 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s ... the gold standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) using ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... Hi-C-based genomic technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the ... and accompanying cloud-based bioinformatics software to perform Hi-C metagenome deconvolution using their ...
(Date:10/6/2017)... ... October 06, 2017 , ... The HealthTech Venture Network (HTVN) ... their fourth annual Conference where founders, investors, innovative practitioners and collaborators are invited ... competition showcasing early stage digital health and med tech companies. , This day-long ...
(Date:10/5/2017)... ... 05, 2017 , ... LabRoots , the leading provider of educational and ... giving back to cancer research with a month-long promotion supporting the advancement of breast ... shoppers can use promo code PinkRibbon to get 10 percent off their purchase of ...
Breaking Biology Technology: