Navigation Links
Dysfunction in cerebellar Calcium channel causes motor disorders and epilepsy
Date:3/21/2013

A dysfunction of a certain Calcium channel, the so called P/Q-type channel, in neurons of the cerebellum is sufficient to cause different motor diseases as well as a special type of epilepsy. This is reported by the research team of Dr. Melanie Mark and Prof. Dr. Stefan Herlitze from the Ruhr-Universitt Bochum. They investigated mice that lacked the ion channel of the P/Q-type in the modulatory input neurons of the cerebellum. "We expect that our results will contribute to the development of treatments for in particular children and young adults suffering from absence epilepsy", Melanie Mark says. The research team from the Department of General Zoology and Neurobiology reports in the "Journal of Neuroscience".

P/Q-type channel defects cause a range of diseases

"One of the main challenging questions in neurobiology related to brain disease is in which neuronal circuit or cell-type the diseases originate," Melanie Mark says. The Bochum researchers aimed at answering this question for certain motor disorders that are caused by cerebellar dysfunction. More specifically, they investigated potential causes of motor incoordination, also known as ataxia, and motor seizures, i.e., dyskinesia. In a previous study in 2011, the researchers showed that a certain Calcium channel type, called P/Q-type channel, in cerebellar neurons can be the origin of the diseases. The channel is expressed throughout the brain, and mutations in this channel cause migraines, different forms of epilepsy, dyskinesia, and ataxia in humans.

Disturbing cerebellar output is sufficient to cause different diseases

"Surprisingly, we found in 2011 that the loss of P/Q-type channels, specifically in the sole output pathway of the cerebellar cortex, the Purkinje cells, not only leads to ataxia and dyskinesia, but also to a disease often occurring in children and young adults, absence epilepsy," Dr. Mark says. The research team thus hypothesized
'/>"/>

Contact: Dr. Melanie Mark
melanie.mark@rub.de
49-234-322-7913
Ruhr-University Bochum
Source:Eurekalert

Page: 1 2

Related biology news :

1. New gene mutations linked to ALS and nerve cell growth dysfunction
2. Mild thyroid dysfunction in early pregnancy linked to serious complications
3. Regenerated cells may restore vision after corneal dysfunction
4. Has modern science become dysfunctional?
5. Waste removal in worms reveals new mechanism to regulate calcium signaling
6. Hebrew University study finds key mechanism in calcium regulation
7. Community-based nutrition education shown to be successful in increasing calcium intake
8. Temple-Penn researchers identify calcium accelerator to keep cell power supply going
9. Calcium supplements remain a valuable tool for maintaining bone health
10. New health-economic model shows benefits of boosting dietary calcium intake
11. Danish researchers release ground-breaking knowledge about calcium pumps in cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... 19, 2014 Nxt-ID, Inc. (Nasdaq: NXTD ... on the growing m-commerce market, updates the "Wocket in Your Pocket" ... lightweight and light middleweight weight classes, Vinny Pazienza (PAZ). ... that Game of Thrones actor Ciaran Hinds ... star Katey Sagal have been cast in ...
(Date:9/18/2014)... - Washington State University researchers have developed a unique ... power waste cleanup in rural areas. , The ... an inexpensive and quick way to clean up waste ... while reducing pollution. , Professor Haluk Beyenal and ... Engineering and Architecture discuss the system in the online ...
(Date:9/18/2014)... located deep in the primitive brainstem has revealed how ... Harvard School of Medicine and the University at Buffalo ... the second "sleep node" identified in the mammalian brain ... to produce deep sleep. , Published online in August ... fully half of all of the brain,s sleep-promoting activity ...
Breaking Biology News(10 mins):NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 2NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 3Researchers develop unique waste cleanup for rural areas 2No sedative necessary: Scientists discover new 'sleep node' in the brain 2
... combined genetic and geographic data of the H5N1 avian ... decade. They found that multiple strains of the virus ... identified many of the migration routes through which the ... H5N1 strains develop and migrate, health officials can better ...
... brewing about whether pre-Columbian Amazonian populations settled in large ... that many conservationists take to be ‘natural.' , This ... and is challenged in a recent paper from Dr. ... findings of Bush’s research may rekindle a debate has ...
... genes from an ancient wheat variety have led to a ... recent set of papers published in the journal Plant Physiology ... Nax2. The genes work by excluding salt from different parts ... the leaves. The discovery of the two genes is the ...
Cached Biology News:UCI scientists reconstruct migration of avian flu virus 2Paper challenges 1491 Amazonian population theories 2Paper challenges 1491 Amazonian population theories 3Paper challenges 1491 Amazonian population theories 4Ancient genes used to produce salt-tolerant wheat 2
(Date:9/20/2014)... 2014 HealthTronics, Inc. , ... radiology products and services, has signed a distribution ... Clinicon Corporation for its high precision laser ... minimally invasive, mobile, surgical technology—offering more choices for ... agreement, HealthTronics will make available Clinicon’s FDA-cleared SureLase™ ...
(Date:9/19/2014)... crop yields to disease risks, the biological characteristics people ... Just as for heightthe textbook example of a complex ... shaped by multiple genetic and environmental influences, making it ... such genes, geneticists typically mate two individuals that differ ... small mouseand then study their descendents, looking for genes ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 ... its potential to revolutionize the world has attracted ... corporations and small start-ups. The early years of ... projects largely due to the high risks involved, ... budgets earmarked for this evolving technology have been ...
(Date:9/19/2014)... 2014  Nektar Therapeutics (NASDAQ: NKTR ... the analgesic profiles of a series of the ... molecules. The preclinical research candidates were created using ... The analgesic properties of kappa receptor agonism ... Kappa opioid receptors are expressed in the ...
Breaking Biology Technology:HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 2HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 3Want to link genes to complex traits? Start with more diversity 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5
... Hammer LLC , a software company in Waukesha that sells ... design programs, said on Thursday it has been acquired by ... announced it would expand its offerings to manufacturers and retailers ... products, and product pictures. Big Hammer operates one of 11 ...
... of research in the history of the University of ... its image from a university of access to a ... build a knowledge-based economy. , ,Abbas Ourmazd, keynote speaker ... Awards, appealed for support for UWMs Research Growth Initiative. ...
... said on Tuesday that a patent it has just ... property in the U.S. , ,The patent covers a combination ... a type of chain reaction that makes copies of DNA ... its existing Invader chemistry. , ,"These important, new patents are ...
Cached Biology Technology:Tech awards keynoter asks for support of UWM transformation 2Tech awards keynoter asks for support of UWM transformation 3
For use with SSP products or any application requiring agarose gel separation • Multiple formats available to meet various throughput needs • Includes replacement parts for each un...
recombination at attR1 and attR2 sites...
...
GlutaMAX-I Supplement...
Biology Products: