Navigation Links
Dysfunction in cerebellar Calcium channel causes motor disorders and epilepsy
Date:3/21/2013

A dysfunction of a certain Calcium channel, the so called P/Q-type channel, in neurons of the cerebellum is sufficient to cause different motor diseases as well as a special type of epilepsy. This is reported by the research team of Dr. Melanie Mark and Prof. Dr. Stefan Herlitze from the Ruhr-Universitt Bochum. They investigated mice that lacked the ion channel of the P/Q-type in the modulatory input neurons of the cerebellum. "We expect that our results will contribute to the development of treatments for in particular children and young adults suffering from absence epilepsy", Melanie Mark says. The research team from the Department of General Zoology and Neurobiology reports in the "Journal of Neuroscience".

P/Q-type channel defects cause a range of diseases

"One of the main challenging questions in neurobiology related to brain disease is in which neuronal circuit or cell-type the diseases originate," Melanie Mark says. The Bochum researchers aimed at answering this question for certain motor disorders that are caused by cerebellar dysfunction. More specifically, they investigated potential causes of motor incoordination, also known as ataxia, and motor seizures, i.e., dyskinesia. In a previous study in 2011, the researchers showed that a certain Calcium channel type, called P/Q-type channel, in cerebellar neurons can be the origin of the diseases. The channel is expressed throughout the brain, and mutations in this channel cause migraines, different forms of epilepsy, dyskinesia, and ataxia in humans.

Disturbing cerebellar output is sufficient to cause different diseases

"Surprisingly, we found in 2011 that the loss of P/Q-type channels, specifically in the sole output pathway of the cerebellar cortex, the Purkinje cells, not only leads to ataxia and dyskinesia, but also to a disease often occurring in children and young adults, absence epilepsy," Dr. Mark says. The research team thus hypothesized that disturbing the output signals of the cerebellum is sufficient to cause the major disease phenotypes associated with the P/Q-type channel. In other words, P/Q-type channel mutations in the cerebellum alone can elicit a range of diseases, even when the same channels in other brain regions are intact.

Disturbing the input to the cerebellum has similar effects as disturbing the output

Mark's team has now found further evidence for this hypothesis. In the present study, the biologists did not disturb the output signals, i.e., the Purkinje cells, directly, but rather the input to these cells. The Purkinje cells are modulated by signals from other neurons, amongst others from the granule cells. "This modulatory input to the Purkinje cells is important for the proper communication between neurons in the cerebellum," Melanie Mark explains. In mice, the researchers disturbed the input signals by genetically altering the granule cells so that they did not express the P/Q-type channel. Like disturbing the cerebellar output in the 2011 study, this manipulation resulted in ataxia, dyskinesia, and absence epilepsy. "The results provide additional evidence that the cerebellum is involved in initiating and/or propagating neurological deficits", Mark sums up. "They also provide an animal model for identifying the specific pathways and molecules in the cerebellum responsible for causing these human diseases."


'/>"/>

Contact: Dr. Melanie Mark
melanie.mark@rub.de
49-234-322-7913
Ruhr-University Bochum
Source:Eurekalert

Related biology news :

1. New gene mutations linked to ALS and nerve cell growth dysfunction
2. Mild thyroid dysfunction in early pregnancy linked to serious complications
3. Regenerated cells may restore vision after corneal dysfunction
4. Has modern science become dysfunctional?
5. Waste removal in worms reveals new mechanism to regulate calcium signaling
6. Hebrew University study finds key mechanism in calcium regulation
7. Community-based nutrition education shown to be successful in increasing calcium intake
8. Temple-Penn researchers identify calcium accelerator to keep cell power supply going
9. Calcium supplements remain a valuable tool for maintaining bone health
10. New health-economic model shows benefits of boosting dietary calcium intake
11. Danish researchers release ground-breaking knowledge about calcium pumps in cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2016)... 18, 2016  Extenua Inc., a pioneering developer ... use and access of ubiquitous on-premise and cloud ... American Cyber.  ... transformational C4ISR and Cyber initiatives in support of ... proven technology solutions," said Steve Visconti , ...
(Date:1/11/2016)... 11, 2016  higi, the leading retail and ... locations, web and mobile, today announced it has ... existing investors. --> ... further innovate higi,s health platform – its network ... – including expanding services and programs to retail ...
(Date:1/7/2016)... MIAMI , Jan. 7, 2016  A United ... became the first court in the country to interpret ... landmark lawsuit to go forward against the photo website ... LLP. BRIAN NORBERG vs. SHUTTERFLY, INC.; ... the plaintiff alleges that Shutterfly violates the Illinois Biometric ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... -- Sangamo BioSciences, Inc. (NASDAQ: SGMO ), the leader ... Lanphier , Sangamo,s president and chief executive officer, will ... Therapeutic ® development programs and an overview of ... Thursday, February 11, 2016, at the Leerink Partners 5 ... being held in New York . ...
(Date:2/4/2016)... China , Feb. 4, 2016 Beike ... and various medical institutions attended a ceremony in late ... integrative, personalized cell therapy in 2016. ... "Shenzhen Clinical Translation Platform for Personalized Cell Therapy" was ... Regional Cell Production Center, both subsidiaries of Beike Biotechnology ...
(Date:2/4/2016)... NEW YORK , February 4, 2016 ... (OTCQB: QBIO), a biotechnology acceleration company is pleased to provide ... --> --> Over the last 3 months ... note and securities purchase agreements exceeding $1,000,000. As a result, ... under our Mannin Research Inc. license agreement and expect that ...
(Date:2/4/2016)... , Feb. 4, 2016 Sinovac Biotech Ltd. ... leading provider of biopharmaceutical products in China ... its board of directors received on February 4, 2016 ... from a consortium comprised of PKU V-Ming ( ... Co., Ltd., CICC Qianhai Development ( Shenzhen ...
Breaking Biology Technology: