Navigation Links
Dynamics of chaperone protein critical in rescuing brains of Alzheimer's mice from neuron damage
Date:12/3/2010

Tampa, FL (Dec. 3, 2010) -- Dynamic regulation of the chaperone protein Hsp27 was required to get rid of abnormally accumulating tau in the brains of mice genetically modified to develop the memory-choking tau tangles associated with Alzheimer's disease, a University of South Florida-led study found.

Researchers at the USF Health Byrd Alzheimer's Institute demonstrated that the effective switching of Hsp27 between its active and deactivated states was critical on two fronts -- to promote the recycling of the tau protein in healthy nerve cells and to clear abnormal tau from the brain before the protein could clump together into the sticky tau neurofibrillary tangles that kill brain cells involved in memory formation. Their findings were published online Nov.17, 2010 in the Journal of Neuroscience.

"Our study shows that Hsp 27 may be a double-edged sword depending upon the contextual environment of neurons in the brain," said the study's principal investigator Chad Dickey, PhD, associate professor of molecular medicine at USF Health. "By better defining the mechanisms linking chaperone proteins to both the tau aggregation and degradation pathways, we can move toward more individualized, effective therapies targeting Alzheimer's and other distinct neurological disorders."

Hsp27 is one of several "chaperone" proteins that supervises the activity of tau inside nerve cells, ensuring that the tau protein is properly folded into its complex form. If tau somehow becomes misfolded, the protein cannot accomplish its normal job of helping maintain the structure of nerve cells. The improperly folded (abnormal) tau starts stacking up into tangles inside cells involved in memory and destroying them.

The USF study was done using mice genetically engineered to develop tau protein tangles like those found in the brains of people with Alzheimer's disease. In one experiment, the researchers injected into the brains of 4-month-old Alzh
'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3300
University of South Florida (USF Health)
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Jump rope aerodynamics
2. The developmental dynamics of the maize leaf transcriptome
3. USDA awards grant to GSU professor to study childhood obesity dynamics
4. How do cells die? Biophotonic tools reveal real-time dynamics in living color
5. Introducing Robofish: Leading the crowd in studying group dynamics
6. New technique allows study of protein folding, dynamics in living cells
7. Local social dynamics key to success of tropical marine conservation areas
8. NTU, Rice establish infodynamics institute
9. Notre Dame study focuses on protein dynamics
10. New edition of popular lab manual presents latest techniques for probing cellular dynamics
11. Researchers take first look at the genetic dynamics of inbreeding depression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Dynamics of chaperone protein critical in rescuing brains of Alzheimer's mice from neuron damage
(Date:12/10/2014)... , Dec. 9, 2014  Wake Forest Baptist Medical Center ... for its School of Medicine. Funding for this $50 ... campaign that will be publicly launched next summer. ... in the former 60 series R.J. Reynolds Tobacco Company ... Construction will begin immediately with plans to be ready ...
(Date:12/10/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/xclcvw/biometrics_market ) ... Market in Japan 2014-2018" report to their ... The integration of biometrics and smart ... upgradation of the driver,s license is one of ... the aforementioned projects, biometrics is being used as ...
(Date:12/5/2014)... , Dec. 4, 2014 Increased ... boosted investments in new testing and inspection technologies. ... given rise to a range of innovative test ... requirements of Generation Y, which is generally more ... a result, product development strategies of test equipment ...
Breaking Biology News(10 mins):Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4
... Boulder, Colorado, USA - Geology doesn,t stop at borders. ... plate and face similar environmental and resource problems. In ... the three countries, the Center of Geoscience and the ... Mexico (Universidad Nacional Autnoma de Mxico; UNAM) are hosting ...
... Cerebral edemas are accumulations of fluid into the ... can result from several factors such as stroke or ... serious problem in neurology. While in other organs swelling ... brain it leads to coma and death. Although there ...
... the sensitivity of Greenland Ice Sheet outlet glaciers to rising ... bathymetry beneath them before accurate predictions of sea-level rise can ... body of sand on Earth, large enough to cover the ... of the oldest evidence of animals burrowing in search of ...
Cached Biology News:Geological Society of America Cordilleran section meets in the heart of Mexico 2Geological Society of America Cordilleran section meets in the heart of Mexico 3Geological Society of America Cordilleran section meets in the heart of Mexico 4Step forward in research into new treatments for brain edema 2Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 2Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 3Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 4Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 5Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 6Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 7Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 8Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 9
(Date:12/24/2014)... 23, 2014 China Biologic Products, Inc. ... leading fully integrated plasma-based biopharmaceutical company in ... majority-owned subsidiary, Shandong Taibang Biological Products Co. Ltd., ... the China Food and Drug Administration (the "CFDA") ... previously disclosed in the Company,s public filings, the ...
(Date:12/24/2014)... Fla. , Dec. 23, 2014  Rock Creek ... that it has filed a Clinical Trial Application (CTA) ... Healthcare products Regulatory Agency (MHRA) seeking regulatory approval to ... lead molecule, Anatabine Citrate. Contingent on the ... conduct a Phase I trial to assess the safety, ...
(Date:12/22/2014)... 22, 2014 /PRNewswire/ - RepliCel Life Sciences Inc. (OTCQB: ... focused on the development of autologous cell therapies, announced ... University of Calgary in conjunction with co-authors from Kyoto ... validates the company,s ongoing clinical research using dermal sheath ... baldness. The paper entitled " Hair Follicle ...
(Date:12/22/2014)... The American Journal of ... research, reviews and editorials addressing developments and pathways ... published a provocative article exploring the role of ... potential treatment of prostate cancer. , The ... the possibility that there could be a connection ...
Breaking Biology Technology:China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4
... , , , , , , ... Type of primers , Primer anneal. temp. , Sensitivity , ... Fidelity in PCR , Tolerance , of non- , ... , of serum components , ...
... , , , , , ... High fidelity cDNA , for cloning , Amplification of ... RACE a , PTT a , ... prevention , , , Expand Re- , ...
... , , for one-step RT-PCR amplification of up to 3 , ... 732 641 100 units , Cat. No. 1 732 650 500 units , ... , , Description , , , Unique ... also includes: , , Expand ...
Cached Biology Technology:Reverse transcriptases suitable for one-step RT-PCRb 2Suggested applications for reverse transcriptases 2Expand High Fidelity PCR System 2Expand High Fidelity PCR System 3
... large numbers of samples may be carried out ... operator attention. System control and data processing ... 4900. The elegant, powerful and very easy ... Windows 98 and 2000., The supplied detector is ...
Narrow-mouth has heavy-duty rim. Approximate graduations are in durable white enamel. Extra large marking space. capacity 125 mL Special grade: student grade...
... Rabbit polyclonal to MSY2/YBOX2 ( Abpromise ... Antigen: Synthetic peptide ... acids 178-227 of human YBX2. ... is proprietary). ...
Standard Fluka For microscopy (Bact., Hist.)...
Biology Products: