Navigation Links
Duke software dramatically speeds enzyme design
Date:2/16/2009

more like they would in real life. Moreover, it simultaneously evaluates what he called "an entire album, or ensemble," of possible shape shifting.

"Thus it not only addresses flexibility. It embraces it," Donald said." "So we might be able to quickly discover things that would take a very long time through purely experimental techniques. It should, in principle, be possible to redesign any enzyme simply by inputting the protein's shape into the algorithm and telling it what you want it to do."

The new report is the latest milestone in a nearly 10-year effort to develop reliable enzyme design algorithms, Donald said. In the process, his group has had a long collaboration with Amy Anderson of the University of Connecticut to biochemically test the algorithm's accuracy using the Gramicidin S Synthetase enzyme system, which produces the natural antibiotic in Bacillus brevis bacteria.

In the new PNAS report, Ivelin Georgiev, Donald's computer science graduate student who is one of K*'s designers, used the latest version of the algorithm to redesign the first step in the biochemical assembly line needed to make the antibiotic.

"Redesigning that first step is a big achievement," Donald said. "We are now beginning work on redesigning the half dozen subsequent steps downstream."

The algorithm includes a "dead-end elimination" feature that can run though all possible chemical interactions and flexible molecular architectures to weed out scenarios that cannot work. Calculating just one redesign might take up to a week in the 230-processor computer cluster housed in Donald's lab, he said.

After all the calculations were completed, biochemist Cheng-Yu Chen, another of Donald's graduate students, confirmed the algorithm's predicted designs in Donald's biochemical wet lab, using bacteria to synthesize some "quite big and tricky proteins," Donald said. "It was not at all trivial to do that, and testing the functions of
'/>"/>

Contact: Monte Basgall
monte.basgall@duke.edu
919-681-8057
Duke University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Radiant Systems Selects BIO-key(R) Biometric Software for POS Solution
2. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
3. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
4. Radiant Systems Selects BIO-key(R) Biometric Software for POS Solution
5. Aware, Inc. Introduces Biometrics Software for Tenprint Autocapture
6. CIC Again Named to Software Magazines Annual Prestigious Software 500 List
7. Titanium Group Signs Letter of Intent to Acquire Multimilion Dollar Medical Software Company and Its Existing Sales Network
8. Titanium Group Signs Letter of Intent to Acquire Multimilion Dollar Medical Software Company and Its Existing Sales Network
9. Software Techniques Inc. Selects M2SYS Fingerprint Software to Meet Continuous Growth and Demand for Desktop Biometric Time & Attendance Solutions
10. LOGICARE Selects M2SYS Biometric Fingerprint Software to Ensure Patient Privacy and Protect Confidential Information
11. M2SYS Introduces Revolutionary Biometric Artificial Intelligence Technology to Significantly Reduce Fingerprint Software False Reject Rates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... 23, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... growing mobile commerce market, announces its biometric payment technology, the ... CNBC television starting March 30 th . ... New York markets. ... excited about our new ad campaign following the recent initial ...
(Date:3/20/2015)... 19, 2015 Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ... - Global Strategic Business Report" report to their offering. ... Geometry in US$ Thousands. The report provides separate comprehensive analytics ... Japan , Europe , ... Rest of World. Annual estimates and forecasts are ...
(Date:3/20/2015)... Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) has announced the addition ... report to their offering. This report analyzes ... report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... . Annual estimates and forecasts are provided for ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... -- In the largest undertaking of its kind, scientists ... a five-year National Institutes of Health (NIH)-funded study to ... the exact causes of hemoglobin toxicity. Hemoglobin in ... can become deadly when cells break open and spill ...
... no scientific evidence that low-level electromagnetic field exposure ... adverse health effects, according to a report presented ... Committee provides advice to authorities about risk management ... assessed the health hazards from low-level electromagnetic fields ...
... Research Institute and Sea Lane Biotechnologies have solved the co-crystal ... in a unique way. The antibody recognizes the crucial structure ... though previously this structure had been thought too small for ... hit this precise spot by using just a small part ...
Cached Biology News:Rice to take part in $10.8 million study of hemoglobin toxicity 2Rice to take part in $10.8 million study of hemoglobin toxicity 3Mobile phones and wireless networks: No evidence of health risk found 2Mobile phones and wireless networks: No evidence of health risk found 3Mobile phones and wireless networks: No evidence of health risk found 4Flu antibody’s 'one-handed grab' may boost effort toward universal vaccine, new therapies 2Flu antibody’s 'one-handed grab' may boost effort toward universal vaccine, new therapies 3
(Date:3/25/2015)... CAMBRIDGE, Mass. and REYKJAVIK, Iceland ... provides comprehensive capabilities for using the genome to create better ... publication of the largest studies of whole-genome data yet undertaken. ... Nature Genetics – are built around ... authored by a team of deCODE scientists led by ...
(Date:3/25/2015)... (PRWEB) March 25, 2015 Data ... Novel Mechanism of Action in Neuromuscular Diseases ... – Cytokinetics, Incorporated (Nasdaq: CYTK) announced the publication ... muscle troponin activator tirasemtiv in the journal Neurotherapeutics. ... IIa “Evidence of Effect” or hypothesis-generating clinical trial ...
(Date:3/25/2015)... the HAGUE, Netherlands , March 25, ... LES Stimulation therapy for chronic gastro-esophageal reflux disease (GERD) ... [ Surgery . 2015; 157(3):556-567 ], establishing ... therapy. The study included 25 patients ... years and taking prescribed daily proton pump inhibitor (PPI) ...
(Date:3/25/2015)... March 25, 2015  18 piglets born recently ... research by scientists in the College of Agriculture and ... a breakthrough in the field of genetic engineering. ... of Animal & Avian Sciences (ANSC) and Ki-Eun ... successfully produced genome-edited pigs using a recently developed, ...
Breaking Biology Technology:Landmark deCODE Studies Demonstrate the Power of Truly Big Genomics for Improving Medicine Worldwide 2Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 2Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 3Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 4Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 5Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 6EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 3University of Maryland Researchers Successfully Produce Genome-edited Pigs Using Revolutionary Technology 2
... FRANCISCO, CA -- September 6, 2007 -- Researchers at ... College of Medicine have discovered a mechanism by which ... disease. AB, which is known to accumulate in the ... of research into the causes and treatment of the ...
... ThermoGenesis,Corp. (Nasdaq: KOOL ), a leading supplier ... administer therapeutic doses of,adult stem cells for treatment of ... for the fourth quarter and full year ended,June 30, ... Call and Webcast Management will host a conference ...
... in Sales by 2016, According to a ... New Report from Decision Resources, WALTHAM, Mass., ... and advisory firms for pharmaceutical and,healthcare issues, finds that Amgen, the ... billion in 2006, and Genentech,the second leading biologics manufacturer with biologic ...
Cached Biology Technology:Gladstone scientists uncover potential mechanism of memory loss in Alzheimer's disease 2ThermoGenesis Corp. to Announce Fourth Quarter and Year End Results for Fiscal Year 2007 on September 12, 2007 2ThermoGenesis Corp. to Announce Fourth Quarter and Year End Results for Fiscal Year 2007 on September 12, 2007 3Amgen and Genentech Brace Themselves for Heavy Pressure From Biogenerics Manufacturers 2
Rabbit polyclonal to ZFP200 ( Abpromise for all tested applications). Antigen: Synthetic peptide: CGKSFNHKTNLNKHER (Human) Entrez Gene ID: 7752 Swiss Protein ID: P98182...
Human Ig Lambda-chain, clone ICO-16, Monoclonal Antibody...
Rabbit polyclonal to Warfarin ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule conjugated to KLH...
WNV Core Antibody...
Biology Products: