Navigation Links
Duke scientists map imprinted genes in human genome
Date:11/29/2007

first author of the study. They fed sequence data from two types of genes ones known to be imprinted and ones believed not to be imprinted into a computer and asked it to discover the differences. This machine learning approach led to an algorithm, which was able like the original Rosetta stone to decode seemingly impenetrable data, in this case, specific DNA sequences that pointed to the presence of imprinted genes.

We cant say for certain that we identified all of them, but we think we found a large number, says Hartemink.

Jirtle, who has studied imprinting for years, notes that imprinting is an epigenetic event, meaning its something that can change a genes function without altering the sequence of its DNA. Imprinted genes are unusually vulnerable to pressures in our environment even what we eat, drink, and breathe. On top of that, epigenetic changes can be inherited. I dont think people realize that.

Several years ago, Jirtle showed that Agouti mice normally fat and yellow when fed certain dietary supplements, would produce brown, normal weight babies. The babies Agouti genes, the ones responsible for color, were the same as the mothers, yet they looked different. Thats epigenetics in action, says Jirtle.

Its estimated that imprinted genes comprise about 1 percent of the human genome, and until now, only several dozen had been identified. Using their new Rosetta stone, however, Jirtle and Hartemink found 156 new likely imprinted genes, and validated two particularly interesting ones on chromosome 8, where none had been found before. One of them, KCNK9, is mostly active in the brain, is known to cause cancer, and may also be linked to bipolar disorder and epilepsy. The second, DLGAP2, is a possible bladder cancer tumor suppressor gene.

Hartemink says experiments to confirm that all 156 new genes are truly imprinted and not just statistically likely candidates will be difficult, mostly because gene exp
'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center  
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Duke scientists map imprinted genes in human genome
(Date:7/10/2014)... , June 27, 2014  Pomerantz LLP has ... Inc. ("Provectus" or the "Company")(NYSE-MKT: PVCT) and certain ... United States District Court, Middle District of ... behalf of a class consisting of all persons ... securities between December 17, 2013 and May 22, ...
(Date:7/10/2014)... Conn. , July 2, 2014 NXT-ID, Inc., (OTCQB: ... reports that CEO Mr. Gino Pereira was interviewed ... show in Tampa Florida . Mr. Pereira ... host Cedric Harris and how the Wocket™ aims ... alternative.  Cedric Harris tells Gino ...
(Date:7/10/2014)... Fingerprint Cards, (FPC,s) new ... (DW). An Asian OEM has selected FPC1021 for a flagship ... August 2014.   FPC is proud to announce ... planned date for start of mass production in August 2014. ... 5M, for delivery in the first half of July. The ...
Breaking Biology News(10 mins):SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2
... a looming water crisis, driven by climate change, growing ... of this issue, the National Science Foundation has selected ... Engineering Research Center (ERC) to address this challenge by ... initial grant is $18.5 million spread over five years, ...
... Scientists at the U.S. Department of Energy,s (DOE) Brookhaven ... the metabolic processes in rapeseed plants - particularly those ... Their goal is to find ways to optimize the ... renewable resources for fuel and industrial chemicals. The ...
... ,(Phoenix ... awarded Robert Garfield, PhD, a researcher at St. Joseph,s Hospital and Medical ... to prevent post-partum hemorrhage. The grant was one of 88 awarded ... help lower the barriers for testing innovative ideas in global health. Phase ...
Cached Biology News:Re-inventing America's urban water infrastructure 2Re-inventing America's urban water infrastructure 3Re-inventing America's urban water infrastructure 4Modeling plant metabolism to optimize oil production 2Modeling plant metabolism to optimize oil production 3
(Date:7/10/2014)... July 10, 2014 Research and Markets ... the "International Photonic Integrated Circuit (Monolithic Integration, ... 2019" report to their offering. ... concept of photonic integration traces its roots in ... promise of photonic integration went unexplored and unfulfilled ...
(Date:7/10/2014)... April 15, 2014 -- According to the International ... nuclear security comes from terrorists acquiring sufficient quantities ... construct a crude nuclear explosive device. The IAEA ... trafficking have involved gram-level quantities, which can be ... According to a new study appearing this week ...
(Date:7/10/2014)... June 17, 2014 Using microscopic polymer light ... gases, researchers at MIT,s Quantum Photonics Laboratory have ... in the parts-per-billion range. Optical sensors are ideal ... high signal-to-noise ratio, compact, lightweight nature, and immunity ... sensors had been developed before, the MIT team ...
(Date:7/10/2014)... psychiatric disorders has been extremely challenging because there are ... insufficient to cause disease. Now investigators reporting in the ... Cell Stem Cell describe a strategy that may ... other risk factors or environmental exposures to affect the ... genetic variant that may predispose individuals to schizophrenia. ...
Breaking Biology Technology:International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Sensitive detection method may help impede illicit nuclear trafficking 2Swell new sensors 2New strategy could uncover genes at the root of psychiatric illnesses 2
... 11 Idenix Pharmaceuticals, Inc., (Nasdaq: IDIX ... results for the fourth quarter of 2008 on Tuesday, ... conjunction with the issuance of the press release, Idenix ... ET on Tuesday, February 17, 2009 to discuss the ...
... XTL,Biopharmaceuticals Ltd. (Nasdaq: XTLB ; TASE: ... Shweiger have been appointed to XTL,s Board of,Directors, effective ... assuming,the role of Co-Chief Executive Officer, with no remuneration, ... Ron Bentsur, Co-Chief Executive Officer ...
... Victhom Human Bionics Inc., "Victhom" (TSX: VHB), announced today ... and treatment of a physiological disorder that most likely ... seizure. , Victhom has recently filed a patent application ... sudden unexpected death in epilepsy (SUDEP) using its neuromodulation ...
Cached Biology Technology:XTL Biopharmaceuticals Announces Appointment of David Grossman and Boaz Shweiger to Board of Directors 2XTL Biopharmaceuticals Announces Appointment of David Grossman and Boaz Shweiger to Board of Directors 3Victhom announces the filing of a patent application to address sudden unexplained death in epilepsy (SUDEP) 2Victhom announces the filing of a patent application to address sudden unexplained death in epilepsy (SUDEP) 3
Takara's Mutan-Super Express Km Kit is designed to achieve site-directed mutagenesis in just one day. It is based on Oligonucleotide-directed Dual Amber (ODA) method, using the advantages of LA (Long...
... TriEx Sf9 Cells and TriEx Insect ... from pTriEx baculovirus constructs. This cell/medium combination ... cell growth and high protein expression levels ... pTriEx-1.14 vectors. Please note that our Ready-Plaque ...
...
...
Biology Products: