Navigation Links
Duke develops nano-scale drug delivery for chemotherapy
Date:11/1/2009

DURHAM, N.C. -- Going smaller could bring better results, especially when it comes to cancer-fighting drugs.

Duke University bioengineers have developed a simple and inexpensive method for loading cancer drug payloads into nano-scale delivery vehicles and demonstrated in animal models that this new nanoformulation can eliminate tumors after a single treatment. After delivering the drug to the tumor, the delivery vehicle breaks down into harmless byproducts, markedly decreasing the toxicity for the recipient.

Nano-delivery systems have become increasingly attractive to researchers because of their ability to efficiently get into tumors. Since blood vessels supplying tumors are more porous, or leaky, than normal vessels, the nanoformulation can more easily enter and accumulate within tumor cells. This means that higher doses of the drug can be delivered, increasing its cancer-killing abilities while decreasing the side effects associated with systematic chemotherapy

"When used to deliver anti-cancer medications in our models, the new formulation has a four-fold higher maximum tolerated dose than the same drug by itself, and it induced nearly complete tumor regression after one injection," said Ashutosh Chilkoti, Theo Pilkington Professor of Biomedical Engineering at Duke's Pratt School of Engineering. "The free drug had only a modest effect in shrinking tumors or in prolonging animal survival".

The results of Chilkoti's experiments were published early online in the journal Nature Materials.

"Just as importantly, we believe, is the novel method we developed to create these drugs," Chilkoti said. "Unlike other approaches, we can produce large quantities simply and inexpensively, and we believe the new method theoretically could be used to improve the effectiveness of other existing cancer drugs."

Central to the new method is how the drug is "attached" to its polypeptide delivery system and whether or not a drug can be dissolved in water.

The delivery system makes use of the bacterium Escherichia coli (E. coli) which has been genetically altered to produce a specific artificial polypeptide known as a chimeric polypeptide. Since E. coli are commonly used to produce proteins, it makes for a simple and reliable production plant for these specific polypeptides with high yield.

When attached to one of these chimeric polypeptides, the drug takes on characteristics that the drug alone does not possess. Most drugs do not dissolve in water, which limits their ability to be taken in by cells. But being attached to a nanoparticle makes the drug soluble.

"When these two elements are combined in a container, they spontaneously self-assemble into a water-soluble nanoparticle," Chilkoti said. "They also self-assemble consistently and reliably in a size of 50 nanometers or so that makes them ideal for cancer therapy. Since many chemotherapeutic drugs are insoluble, we believe that this new approach could work for them as well."

The latest experiments involved doxorubicin, a commonly used agent for the treatment of cancers of the blood, breast, ovaries and other organs. The researchers injected mice with tumors implanted under their skin with either the chimeric polypeptide-doxorubicin combination or doxorubicin alone.

The mice treated with doxorubicin alone had an average tumor size 25 times greater than those treated with the new combination. The average survival time for the doxorubicin-treated mice was 27 days, compared to more than 66 days for mice getting the new formulation.

The Duke researchers now plan to test the new combination on different types of cancer, as well as tumors growing within different organs. They will also try combining these chimeric polypeptides with other insoluble drugs and test their effectiveness against tumors.


'/>"/>

Contact: Richard Merritt
richard.merritt@duke.edu
919-660-8414
Duke University
Source:Eurekalert  

Related biology news :

1. GSU professor develops new method to help keep fruit, vegetables and flowers fresh
2. Epigentek Develops a New Method of Measuring Global DNA Methylation
3. Carnegie Mellon develops innovative method to detect genetic causes of complex diseases
4. HudsonAlpha investigator develops rapid response swine flu test
5. CSHL team develops mouse models of leukemia that predict response to chemotherapy
6. MIT student develops new innovations to selectively kill cancer cells
7. When acute hepatitis develops into chronic hepatitis
8. Fujitsu Develops HDD Security Technology Based on Opal SSC Standards
9. MIT develops new way to fuse cells
10. Hypertension develops early, silently, in African-American men
11. Iowa State researcher develops new treatment method for canine eye diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Duke develops nano-scale drug delivery for chemotherapy
(Date:3/11/2016)... March 11, 2016 --> ... research report "Image Recognition Market by Technology (Pattern Recognition), ... Advertising), by Deployment Type (On-Premises and Cloud), by Industry ... published by MarketsandMarkets, the global market is expected to ... 29.98 Billion by 2020, at a CAGR of 19.1%. ...
(Date:3/10/2016)... , March 10, 2016   Unisys Corporation (NYSE: ... Border Protection (CBP) is testing its biometric identity solution ... Diego to help identify certain non-U.S. citizens leaving ... The test, designed to help determine the efficiency and accuracy ... in February and will run until May 2016. --> ...
(Date:3/9/2016)... -- Nigeria . Recently, the ... public service employees either did not exist with their ...    --> Nigeria . Recently, ... 23,000 public service employees either did not exist with ... unlawfully.    --> DERMALOG, the biometrics innovation ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... ... 23, 2016 , ... PrecisionAg® Media has released its latest ... The paper outlines the key trends that are creating both opportunities and challenges ... lot of highs and lows as the precision agriculture market has grown and ...
(Date:5/23/2016)... Oxitec CEO Hadyn Parry will testify ... before the United States House Committee on Science, Space and ... controlling the spread of the Aedes aegypti mosquito, ... (Logo: http://photos.prnewswire.com/prnh/20150630/227348 ) Oxitec has pioneered ... in Brazil , Panama ...
(Date:5/23/2016)... ... May 23, 2016 , ... RoviSys, a leading independent ... Aurora, Ohio, has broken ground on a new building in Holly Springs, NC. ... this new location solidifies a commitment to business in the region. The new ...
(Date:5/22/2016)... ... May 22, 2016 , ... Doctors in Rome say micronutrients found ... cancer, malignant mesothelioma. Surviving Mesothelioma has just posted an article on the new research. ... Rome’s Department of Clinical Sciences and Translational Medicine evaluated more than 150 studies on ...
Breaking Biology Technology: