Navigation Links
Duke-NIEHS team shows how DNA repairs may reshape the genome
Date:8/13/2008

kes for an Achilles heel among humans," Argueso said. "If you have a break in this repeated part, you can repair not only from the same chromosome, but also from a similar repeated sequence in many other places in the genome."

Sequencing the genomes of different humans has turned up a surprising amount of structural variation between individuals, said Thomas D. Petes, Ph.D., chair of Duke molecular genetics and microbiology and co-author of the yeast study. "We expected to see primarily single base pair changes or small deletions and insertions. No one expected to see that one person would have two copies of a gene, while others would have one or three copies of the same gene."

These human studies also showed that many of the rearrangements found in humans are at sites of repeated DNA, which may occur through a mechanism similar to what this study found in yeast.

Petes said this work with yeast also could prove relevant to cancer research. "Most solid tumors have a high level of these rearrangements, as well as a high level of extra chromosomes; recombination between repeated genes is clearly one way of generating rearrangements, although some rearrangements also occur by other pathways," he said. "It is an evolutionary battle between normal cells and tumor cells. One way that tumor cells can break free of normal cell growth regulation is to rearrange their genomes."


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Nano vaccine for hepatitis B shows promise for third world
2. Experimental chemotherapy regimen shows promise in treating advanced lung cancer
3. New breastfeeding study shows most moms quit early
4. When our protective armor shows weakness
5. Lab study shows methadone breaks resistance in untreatable forms of leukemia
6. Immunotherapy in high-risk pediatric sarcomas shows promising response
7. New study shows compounds from soy affect brain and reproductive development
8. OSU study shows exposure to bad air raises blood pressure
9. Study shows parasites outweigh predators
10. Study shows increased education on nanotech, human enhancement increases public concerns
11. Sociological research shows combined impact of genetics, social factors on delinquency
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2013)... Science Foundation (NSF) planning grant will help establish the ... program of the University of Illinois at Urbana-Champaign and ... will be devoted to research in drying moist, porous ... and paper products; chemical products; textiles; and biopharmaceuticals," said ... science and human nutrition and the Illinois site director. ...
(Date:5/19/2013)... electricity-producing bacteria that can grow using hydrogen gas as ... sole source of carbon. Researchers at the University ... General Meeting of the American Society for Microbiology. , ... on hydrogen," says Amit Kumar, a researcher on the ... the Lovley Lab Group at the university. , Under ...
(Date:5/18/2013)... An increasing number of U.S. children are ... according to research presented at Digestive Disease Week ... researchers at the Cleveland Clinic Children,s Hospital found ... exhaled breath compared to their lean counterparts. The ... that can be correlated to potential complications associated ...
Breaking Biology News(10 mins):NSF approves planning grant for Center for Advanced Research in Drying 2New research identifies risks, interventions for children's GI health 2New research identifies risks, interventions for children's GI health 3
... control weight, lower fat and cholesterol levels, and aid in ... Industry, the magazine of the SCI. , Yellow soya has ... one of the reasons why frozen food manufacturer Birds Eye ... of Korean researchers has shown that black soya may be ...
... bones undergo remodeling every day of our lives, as old ... In diseases such as osteoporosis, an imbalance in this process ... the Weizmann Institute of Science, which recently appeared in the ... the roving cells whose job is to digest bone seal ...
... of statistics, researchers are sounding a new alarm about growing ... overall number of syphilis cases in the United States fell ... because of a nationwide prevention campaign aimed at heterosexuals. Nevertheless, ... decade. , "The entire nation was caught unawares," ...
Cached Biology News:Ring-around-the-cell 2Syphilis rate on rise in US gay, bisexual men 2
(Date:5/21/2013)... -- Personal Genome Diagnostics Inc. (PGDx), today announced that ... in genomic analysis of defined cancer subtypes to ... Medicines.  PGDx is an innovator in conducting patient-specific ... and Blueprint Medicines is an expert in developing ... patient population. "This collaboration brings together ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 NANONEX ... nanoimprint solutions , today announced the successful delivery ... manufacturing system, the NX-M200B, to a major Japanese ... is a fully-automated, production-ready, advanced nanoimprint lithography tool ... of wafer and substrate sizes and types. Based ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Possible mold re-infestation ... so, according to a report from eagletribune.com posted May 14, ... In case the result is positive, My Cleaning Products offered ... harmful chemical ingredients. , It was said in the Eagle ... in the campus sparked after a first-grade classroom was ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 The Formulate ... display solution for sales and marketing teams looking for a ... describes the kit as “everything you’ll need to put together ... Display Kit comes with a number of displays and accessories ... booth 20 feet by 20 feet in size. These components ...
Breaking Biology Technology:Personal Genome Diagnostics And Blueprint Medicines Form Collaboration to Identify Novel Kinase Targets 2Personal Genome Diagnostics And Blueprint Medicines Form Collaboration to Identify Novel Kinase Targets 3Nanonex Announces the Shipment and Installation of an Innovative Nanoimprint Lithography System for Fully Automated Manufacturing 2Possible Mold Re-infestation Gets Guilmette School Scheduled for Re-inspection, My Cleaning Products Offers Tip How to Kill Mold Safely If Inspection Turns Positive 2Possible Mold Re-infestation Gets Guilmette School Scheduled for Re-inspection, My Cleaning Products Offers Tip How to Kill Mold Safely If Inspection Turns Positive 3GLM Displays Announces All-in-One Formulate Fusion Fabric Display Kit 2
... who elevated technology and business coverage at Madison Magazine, ... He was 53. , ,Before becoming editor of ... editor and, previously, national-foreign editor of the Wisconsin State ... and editing stints in Montana, Minnesota and South Dakota, ...
... hearing a lot of talk about customers. Calling on ... after so many years of loose talk about brand ... customers establish the brand reputation as much as the ... , ,For two incredible software companies, customers never really ...
... fluffy snow fell over Pittsburgh as I returned from Thanksgiving celebrations. ... and gift giving cannot be far away. This season, the tech ... are a few of my favorites. , , FOR THE NETWORKED ... and shipping this week, the Mirra Personal Server is among the ...
Cached Biology Technology:Madison Magazine Editor Dies of Lung Cancer 2The Secret of Success: Listen To Customers 2The Secret of Success: Listen To Customers 3Holiday Tech Gizmo's to Give and Get 2
... Twister II Microplate Handler is a ... for integrating BioTeks washers, readers and ... microplate capacity, ultimate flexibility and intuitive ... adding capacity to single devices or ...
XPLAC (S-17)...
Request Info...
ZBP-89 (S-15)...
Biology Products: