Navigation Links
Duke Medicine news -- Genome sequencing of Burkitt Lymphoma reveals unique mutation
Date:11/12/2012

DURHAM, N.C. In the first broad genetic landscape mapped of a Burkitt lymphoma tumor, scientists at Duke Medicine and their collaborators identified 70 mutations, including several that had not previously been associated with cancer and a new one that was unique to the disease.

Findings from the genetic sequencing of Burkitt lymphoma, an aggressive form of lymphoma, could be used to develop new drugs or aim existing therapies at mutations known to be susceptible. The researchers published their findings online Sunday, Nov. 11, 2012, in the journal Nature Genetics.

"This study lays out the most common genetic alterations in the disease, and allows us to understand the biology of the disease so we can design better therapies," said Sandeep S. Dave, M.D., MBA, MS, associate professor at Duke and senior author of the study.

Dave and colleagues sequenced the first complete Burkitt lymphoma genome, plus the genes from 59 additional Burkitt cases and 94 diffuse large B cell lymphomas, which share many of the same characteristics of Burkitt lymphoma. Similarities between the malignancies can often lead to mistaken diagnoses and failed treatments.

The researchers reported striking differences in the gene mutation patterns of Burkitt lymphomas vs. the diffuse large B cell lymphomas.

"It's important that doctors make the right diagnosis for Burkitt lymphoma, which can be cured with the correct therapies," Dave said. "But if misdiagnosed and given the standard chemotherapy regimes for diffuse large B cell lymphomas, Burkitt lymphoma patients invariably relapse."

The analysis identified 70 genes that were frequently mutated in the Burkitt lymphomas, including a number of genes that were identified in cancer for the first time. One of the newly identified gene mutations, ID3, appeared in 34 percent of the Burkitt cases, but was not evident in any of the diffuse large B cell lymphomas. The mutation has a silencin
'/>"/>

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Privately owned genetic databases may hinder diagnosis and bar the way to the arrival of personalized medicine
2. AVT Develops Biometrically Secure Medicine Storage and Retrieval System for Medbox RX
3. Discovery of reprogramming signature may help further stem cell-based regenerative medicine research
4. BGI Tech develops whole exome sequencing analysis of FFPE DNA samples to boost biomedicine
5. How to Differentiate Your Pharmaceutical Product in the Personalized Medicine Segment
6. Annals of Internal Medicine tip sheet for Sept. 4, 2012
7. Prestigious Royal Society of Tropical Medicine and Hygiene journals join Oxford University Press
8. MDA supports Duchenne muscular dystrophy research by University of Nevada School of Medicine
9. Creating a future of personalized medicine: U-M forms joint venture for DNA diagnostics
10. Nature as a source of new medicines subject of ICNPR in NYC
11. Zebrafish -- the stars of biomedicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/8/2015)... N.J. and NEW YORK , July 8, ... Guidepoint today announced BD & Guidepoint Mentor, ... with free access to Guidepoint,s expert network services. ... are developing cutting-edge technologies to improve healthcare delivery and ... research manager, each start-up entrepreneur will be able to ...
(Date:7/7/2015)... MOUNTAIN VIEW, Calif. , July 7, 2015 ... mobile biometrics market, Frost & Sullivan recognizes Credence ... & Sullivan Entrepreneurial Company of the Year ... product suite to aid in its mission of ... and under-recognized populations globally. As Credence ID was ...
(Date:7/2/2015)... -- Fingerprint Cards has received an order for ... the distributor World Peace Industrial Group (WPI), part of WPG ... Asia . Deliveries are planned to take place during ... smartphone manufacturers in Asia . The order ... guidance of approximately 2,200 MSEK for 2015. Jörgen ...
Breaking Biology News(10 mins):BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... WALL, N.J., Dec. 3 BIO-key International, Inc. (OTC ... and finger-based biometric identification solutions, announced that a majority ... today approved the sale of the company,s Law Enforcement ... voted, 98.6% were cast in favor and 1.2% were ...
... , , FALLS CHURCH, Va., Dec. 9 ... the American Association for Laboratory Accreditation awarded the International ... the company,s Test Lab, which is part of the ... Lab is the second biometrics test laboratory in the ...
... GAINESVILLE, Fla. When treating devastating brain diseases such ... bags to find something to help a patient. But ... vast majority of patients with ataxia disabling disorders that ... Florida neurologists are trying to change that with the help ...
Cached Biology News:BIO-key(R) Shareholders Overwhelmingly Approve Sale of Law Enforcement Division 2BIO-key(R) Shareholders Overwhelmingly Approve Sale of Law Enforcement Division 3CSC's Identity Management and Biometric Test Lab Achieves ISO/IEC 17025 Accreditation 2UF to lead national effort to help patients with rare brain disease 2UF to lead national effort to help patients with rare brain disease 3
(Date:8/4/2015)... -- Blueprint Medicines (NASDAQ: BPMC ), a leader in ... defined diseases, today announced that Jeffrey Albers , ... the 2015 Wedbush PacGrow Healthcare Conference on Tuesday, August ... live webcast of the event will be available by ... at www.blueprintmedicines.com . An archived replay of the ...
(Date:8/4/2015)... CA (PRWEB) , ... August 04, 2015 , ... On ... by inviting a diverse selection of entrepreneurs from across the United States to talk ... Jessica Richman is honored to be chosen to be among the attendees. , One ...
(Date:8/4/2015)... , Aug. 4, 2015 /PRNewswire/ -- Sinovac Biotech Ltd. (Nasdaq: ... in China , today announced that ... second quarter, ended June 30, 2015, after market close ... conference call on Thursday, August 13, 2015, at 8:00 ... China Standard Time) to review the Company,s financial results ...
(Date:8/3/2015)...  ArroGen Group, an integrated advanced forensic solutions ... (FMID) technology Aug. 2-8 at the International Association ... Calif. FMID, a new ... agents, district attorneys and government agencies to build ... By analyzing chemical residues on fingerprints taken from ...
Breaking Biology Technology:White House Invites uBiome CEO Jessica Richman to First-Ever Startup Demo Day 2Sinovac to Host Conference Call to Report Second Quarter 2015 Unaudited Financial Results 2ArroGen Previews New Fingerprint Molecular Identification Technology 2
... in carbon-based nano-materials and devices have open ... Nanotechnology,s ability to manipulate carbon atoms and ... nanoscale materials and novel device structures with ... nanotechnology is anticipated to dramatically change every ...
... HILL, N.C., Jan. 12, 2011 Cempra Pharmaceuticals ... of solithromycin (CEM-101), the first fluoroketolide antibiotic, at ... Advanced Research and Development Authority (BARDA) industry day ...   Solithromycin is a clinical-stage fluoroketolide ...
... Cancer Research Center basic scientists Roger Brent, Ph.D., a ... and geneticist, have been elected fellows of the American ... as a fellow is an honor bestowed upon AAAS ... of the Hutchinson Center,s Basic Sciences Division, is being ...
Cached Biology Technology:Carbon-Based Nano-Materials and Devices Conference 2Carbon-Based Nano-Materials and Devices Conference 3Carbon-Based Nano-Materials and Devices Conference 4Cempra Pharmaceuticals Profiles the Broad Spectrum and Potent Activity Profile of Solithromycin (CEM-101) at the 5th Annual PHEMCE Stakeholders Workshop and BARDA Industry Day 2Cempra Pharmaceuticals Profiles the Broad Spectrum and Potent Activity Profile of Solithromycin (CEM-101) at the 5th Annual PHEMCE Stakeholders Workshop and BARDA Industry Day 3Roger Brent and Robert Eisenman Named AAAS Fellows 2Roger Brent and Robert Eisenman Named AAAS Fellows 3