Navigation Links
Dual action polyclonal antibody may offer more effective, safer protection against osteoporosis
Date:8/20/2012

A new study suggests that a polyclonal antibody that blocks follicle-stimulating hormone (FSH) in mice without ovaries might offer a more effective way to prevent or arrest osteoporosis than currently available treatments.

The study used a mouse model of menopause to show that an injection of a polyclonal antipeptide antibody enhances bone regeneration by simultaneously slowing bone destruction and building bone, say researchers at the Mount Sinai School of Medicine, New York. In addition, the monoclonal antibody is likely to be safer because it is cleared from the blood and is not retained in bone.

Results from the study are published online August 20 in the journal Proceedings of the National Academy of Sciences.

"Bone loss in women begins very early, at least two to three years before a woman's last period and within eight to ten years, a woman will lose 50% of her lifetime bone loss," says the study's senior investigator, Mone Zaidi, MD, Professor of Medicine and of Structural and Chemical Biology, at Mount Sinai School of Medicine in New York." It occurs painlessly, without notice up to a point where women fracture."

Zaidi, who is director, of the Mount Sinai Bone Program, at Mount Sinai School of Medicine, New York, is the senior investigator of the research that developed the polyclonal antipeptide antibody to FSH and tested it in mice whose ovaries were removed. Peptides are short chains of amino acids, and the FSH antibody is a highly specific antibody.

"A few years ago, we showed that FSH [follicle stimulating hormone] directly regulates bone by bypassing the estrogen axis," says Zaidi. FSH rises early in menopause, stimulates bone removal and negatively regulates bone formation. "By blocking FSH with the FSH-specific polyclonal antibody, we were able to block bone resorption by osteoclasts [cells that break down bone] and stimulate bone formation through osteoblasts cells [cells that build bone]."

Zaidi summed up the research team's goal: "Our aim is to find a way to prevent osteoporosis rather than simply treat established disease using medicines that are well tolerated. We believe that a future humanized monoclonal antibody to FSH is likely to be safer than existing treatments because it will not reside in the bone."


'/>"/>
Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related biology news :

1. China Botanic Receives Patent on its Schisandra Lignin Extraction Method
2. Stanford-SLAC team uses X-ray imaging to observe running batteries in action
3. WALTHAM® demonstrates commitment to scientific dialogue and exchange at international human animal interaction conference
4. Scientists join forces in call for action to save coral reefs
5. Robot vision: Muscle-like action allows camera to mimic human eye movement
6. How bacteria change movement direction in response to oxygen: Molecular interactions unravelled
7. Leading childhood asthma group supports federal asthma action plan to reduce disparities
8. GMES in Action conference in Copenhagen
9. La Jolla Institute discovery could lead to new way to screen drugs for adverse reactions
10. Discovered a new checkpoint of cell cycle control through joint action of 2 proteins
11. G protein-coupled receptor mediates the action of castor oil
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... -- NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" ... of independent Directors Mr. Robin D. Richards and ... furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer ... guidance and benefiting from their considerable expertise as we move ...
(Date:4/5/2017)... 4, 2017 KEY FINDINGS The ... at a CAGR of 25.76% during the forecast period ... primary factor for the growth of the stem cell ... MARKET INSIGHTS The global stem cell market ... and geography. The stem cell market of the product ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... , ... May 25, 2017 , ... ... the full process behind each occurrence. Live cell imaging using fluorescence microscopy is ... the use of automated fluorescence microscopy methods will be discussed, from small animal ...
(Date:5/24/2017)... ... 23, 2017 , ... Federal funding for basic and applied scientific research — ... and other vital technologies — deserves continued support, say leaders of SPIE, the ... today in responding to the President’s budget request for Fiscal Year 2018. , The ...
(Date:5/23/2017)... Yorba Linda, Ca (PRWEB) , ... ... ... stem cells (PSCs) offer an unlimited source of human cardiovascular cells for ... efficient cardiac-directed differentiation methods makes it possible to generate large numbers of ...
(Date:5/23/2017)... , ... May 23, 2017 , ... ... advanced technology applications, has announced a facility expansion to accommodate its rapid growth. ... feet of new workspace and renovation of the existing areas. The expansion includes, ...
Breaking Biology Technology: