Navigation Links
Drugs needed to preserve eggs for reproduction need to be given in stages
Date:4/29/2009

AUGUSTA, Ga. Cryoprotectants needed to preserve eggs for reproduction need to be given in stages, albeit rapid ones, say scientists who have developed a mathematical model that predicts optimal time for loading and unloading these drugs.

Their studies in Rhesus monkey eggs, which are very similar to human eggs, show that a two-step process of easing into and out of the drugs needed to help protect eggs at subzero temperatures dramatically reduces the amount eggs contract and expand in the process.

These dramatic size shifts can literally rip an egg apart or, at the very least, reduce the chances it can be fertilized, says Dr. Ali Eroglu, reproductive biologist and cryobiologist in the Medical College of Georgia Schools of Medicine and Graduate Studies.

Scientists first looked at how fast the three most commonly used cryoprotectants dimethylsulfoxide, ethylene glycol and propylene glycol permeate monkey eggs. Faster permeability is better with these drugs which must be given at room temperature when their toxicity levels are high. With permeability rates in hand, MCG scientists used a mathematical model, developed in collaboration with Villanova University in Pennsylvania, to successfully predict optimal loading and removal times.

They found propylene glycol works best in monkeys. The drug penetrated the egg membrane faster and got out faster, Dr. Eroglu and his colleagues report in the April issue of Molecular Reproduction & Development.

All of the drugs worked best when used incrementally: putting some in the medium around the egg and a few minutes later adding a little more when it was time for cryopreservation and, conversely, transferring them to increasingly lower concentrations of the drugs when it was time for thawing.

While still less than 10 percent, success rates for egg preservation to help protect an endangered species or enable a cancer patient to retain fertility have improved in re
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New light on bipolar treatment drugs
2. Male impotence drugs may deserve a second look in women
3. Research could lead to new non-antibiotic drugs to counter hospital infections
4. UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs
5. An underwater drugstore?
6. Canadian scientist mines drugs database for new diabetes treatment
7. Scientists mine drugs database for new diabetes treatment
8. Breaking the barrier: Discovery of anti-resistance factors and novel ocean drugs
9. Compounds could be new class of cancer drugs
10. In India: A search for more effective tuberculosis drugs
11. New discovery may lead to new class of allergy drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drugs needed to preserve eggs for reproduction need to be given in stages
(Date:5/27/2015)... 27, 2015   Codonics (codonics.com), ... and image documentation solutions and Omnicell ... automation solutions, is pleased to announce their ... Safe Label System® (SLS), an award-winning FDA ... the Omnicell Anesthesia Workstation, helps prevent medication ...
(Date:5/26/2015)... , May 26, 2015 ... the addition of the "Saudi Arabia Biometric ... to their offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,The ... is projected to grow at over ... growth is attributed to the surging demand for ...
(Date:5/25/2015)... , May 25, 2015  Australia,s market for wearable ... although 2014 saw the advent of several trials and ... April 2015 is expected to ignite interest in wearables ... Australia . This in turn will ... and drive new partnerships amongst vendors and distributors. ...
Breaking Biology News(10 mins):Codonics and Omnicell Expand Partnership 2Codonics and Omnicell Expand Partnership 3Codonics and Omnicell Expand Partnership 4Saudi Arabia Biometric Systems Market Forecast and Opportunities, 2020 with Morpho Safran, ZK Technlogy, and Suprema Dominating 2Australian wearables market to grow at CAGR of 78%; revenue of A$1 billion by 2018, says Frost & Sullivan 2Australian wearables market to grow at CAGR of 78%; revenue of A$1 billion by 2018, says Frost & Sullivan 3Australian wearables market to grow at CAGR of 78%; revenue of A$1 billion by 2018, says Frost & Sullivan 4
... pollution and heavy fishingare adding insult to injury in ... by the Wildlife Conservation Society and the University of ... found that pollution and overfishing on reef systems have ... wormsthat further degrade corals, a discovery that underlines the ...
... at UCLA,s Jonsson Cancer Center found that the children ... having retinoblastoma, a malignant tumor of the retina which ... which focused on babies born in California, also found ... for retinoblastoma, as were children born to women with ...
... are overweight or obese can encounter a host of health ... children grow and develop, at least initially. In a ... a team led by a University of Iowa researcher compared ... obese mothers with those born to normal-weight mothers. ...
Cached Biology News:Microbes, sponges, and worms add to coral reef woes 2Microbes, sponges, and worms add to coral reef woes 3US-born Latinas at great risk of having babies with retinoblastoma 2Infants of overweight mothers grow more slowly 2Infants of overweight mothers grow more slowly 3
(Date:5/27/2015)... 26, 2015 Research and Markets ... of Jain PharmaBiotech,s new report "Molecular ... to their offering. This report ... that will play an important role in ... forensics and biological warfare in the 21st ...
(Date:5/27/2015)... May 26, 2015 Research and Markets( ... "Global Breast Cancer Monoclonal Antibodies Market Outlook ... Globally, Roche seems to dominate the breast cancer ... block buster molecule, Herceptin has been able to ... found that breast cancer cells become recalcitrant and ...
(Date:5/27/2015)... The Academy of Model Aeronautics Foundation would ... Model Aviation Day. The third annual celebration will be August ... the model aviation hobby nation-wide and to introduce model flying ... 2,350 chartered clubs to celebrate the hobby and share it ... There will also be a local event at the AMA ...
(Date:5/27/2015)... May 27, 2015 Expanding in a ... manufacturer Avalon Biomed Inc. recently inked a ... Mokuda Dental Co. Ltd. , the largest endodontic distributor ... the international market for Avalon Biomed, which manufactures Grey ... tricalcium silicate-based dental cements that have won renown from ...
Breaking Biology Technology:Global Molecular Diagnostics Market 2015-2024 - Analysis of Key Technologies, Markets and Companies 2Global Molecular Diagnostics Market 2015-2024 - Analysis of Key Technologies, Markets and Companies 3Global Breast Cancer Monoclonal Antibodies Market Outlook 2020 2Global Breast Cancer Monoclonal Antibodies Market Outlook 2020 3Academy of Model Aeronautics Foundation to host National Model Aviation Day Motorcycle Rally and Family Fest in Muncie, IN 2Academy of Model Aeronautics Foundation to host National Model Aviation Day Motorcycle Rally and Family Fest in Muncie, IN 3Dental Manufacturer Avalon Biomed Inks Major Deal with Japanese Distributor 2Dental Manufacturer Avalon Biomed Inks Major Deal with Japanese Distributor 3
... Business Development Efforts, SALT LAKE CITY, Sept. ... the development of molecular diagnostic and motion preserving,technologies ... Joe Ross has,joined the executive management team as ... In this new role, Ross will oversee Axial ...
... 14% from the, prior year,s third quarter - Earnings per share ... - Operating cash flow of $23 million, (Year-to-date operating cash flow of ... ... Martek Biosciences,Corporation (Nasdaq: MATK ) today announced its financial results ...
... and National Development in Taiwan, 1950-2000, Celebrates ... Editor of a Comprehensive History of ... Dialogue on a National Health Care System ... Worth Studying, NEW YORK, Sept. 4 ...
Cached Biology Technology:Axial Biotech appoints new Vice President of Strategic Initiatives 2Martek Announces Third Quarter 2008 Financial Results 2Martek Announces Third Quarter 2008 Financial Results 3Martek Announces Third Quarter 2008 Financial Results 4Martek Announces Third Quarter 2008 Financial Results 5Martek Announces Third Quarter 2008 Financial Results 6Martek Announces Third Quarter 2008 Financial Results 7Martek Announces Third Quarter 2008 Financial Results 8Martek Announces Third Quarter 2008 Financial Results 9Martek Announces Third Quarter 2008 Financial Results 10ABMAC Foundation Announces Publication of an Historic Volume Documenting the Creation of a National Health Care System in Taiwan 2ABMAC Foundation Announces Publication of an Historic Volume Documenting the Creation of a National Health Care System in Taiwan 3
Mouse polyclonal antibody raised against a partial recombinant QPCT. NCBI Entrez Gene ID = 25797...
... recombinant IFNA2. Immunogen: Human IFNA2 ... in E. coli. The biological activity was ... OMIM: 147562, GeneID: ... MA Code: ABV0P9DPB ...
... longer need to perform time consuming and inaccurate ... Surveyor, any found variants of the sample when ... in our mutation electropherogram as a sharp peak. ... analysis mode is over 99%, with sensitivity to ...
...
Biology Products: