Navigation Links
Drugs from lizard saliva reduces the cravings for food
Date:5/15/2012

A drug made from the saliva of the Gila monster lizard is effective in reducing the craving for food. Researchers at the Sahlgrenska Academy, University of Gothenburg, have tested the drug on rats, who after treatment ceased their cravings for both food and chocolate.

An increasing number of patients suffering from type 2 diabetes are offered a pharmaceutical preparation called Exenatide, which helps them to control their blood sugar. The drug is a synthetic version of a natural substance called exendin-4, which is obtained from a rather unusual source the saliva of the Gila monster lizard (Heloderma suspectum), North America's largest lizard.

Unexpected effect

Researchers at the Sahlgrenska Academy at the University of Gothenburg, have now found an entirely new and unexpected effect of the lizard substance.

Reduces the cravings for food

In a study with rats published in the Journal of Neuroscience, Assistant Professor Karolina Skibicka and her colleagues show that exendin-4 effectively reduces the cravings for food.

"This is both unknown and quite unexpected effect," comments an enthusiastic Karolina Skibicka:

" Our decision to eat is linked to the same mechanisms in the brain which control addictive behaviours. We have shown that exendin-4 affects the reward and motivation regions of the brain"

Significant findings

The implications of the findings are significant" states Suzanne Dickson, Professor of Physiology at the Sahlgrenska Academy: "Most dieting fails because we are obsessed with the desire to eat, especially tempting foods like sweets. As exendin-4 suppresses the cravings for food, it can help obese people to take control of their weight," suggests Professor Dickson.

Treatment for eating disorders

Research on exendin-4 also gives hope for new ways to treat diseases related to eating disorders, for example, compulsive overeating.

Another hypothesis for the Gothenburg researchers' continuing studies is that exendin-4 may be used to reduce the craving for alcohol.

"It is the same brain regions which are involved in food cravings and alcohol cravings, so it would be very interesting to test whether exendin-4 also reduces the cravings for alcohol," suggests Assistant Professor Skibicka.


'/>"/>

Contact: Karolina Skibicka
karolina.skibicka@neuro.gu.se
46-031-786-3533
University of Gothenburg
Source:Eurekalert  

Related biology news :

1. Study raises questions about use of anti-epilepsy drugs in newborns
2. Internet and new drugs: A challenge for public health
3. Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
4. Genetic variation in East Asians found to explain resistance to cancer drugs
5. Nanopills release drugs directly from the inside of cells
6. Newly released FDA draft guidelines for biosimilar drugs to be discussed at conference
7. Switching antiepileptic drugs could increase risk of seizures
8. 4 new drugs will change prostate cancer care
9. New subtype of ovarian cancer may be vulnerable to anti-angiogenic drugs
10. New smart nanotherapeutics can deliver drugs directly to the pancreas
11. Drugs used to overcome cancer may also combat antibiotic resistance: McMaster researchers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drugs from lizard saliva reduces the cravings for food
(Date:5/16/2017)... , May 16, 2017   Bridge Patient ... organizations, and MD EMR Systems , an ... partner for GE, have established a partnership to ... product and the GE Centricity™ products, including Centricity ... These new integrations will allow ...
(Date:4/19/2017)... April 19, 2017 The global ... landscape is marked by the presence of several large ... held by five major players - 3M Cogent, NEC ... accounted for nearly 61% of the global military biometric ... in the global military biometrics market boast global presence, ...
(Date:4/13/2017)... 13, 2017 UBM,s Advanced Design and Manufacturing ... feature emerging and evolving technology through its 3D Printing ... run alongside the expo portion of the event and ... demonstrations focused on trending topics within 3D printing and ... manufacturing event will take place June 13-15, 2017 at the ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... Canada (PRWEB) , ... May 23, 2017 , ... ... Firmex FileSend, a cloud-based file transfer solution that makes it easy for organizations ... without having to worry about cumbersome FTP software or email file size limitations. ...
(Date:5/23/2017)... ... May 22, 2017 , ... NetDimensions has been ranked ... Research Globe™ for Corporate Learning, 2017. , Aragon Research defines Leaders as organizations ... effectively perform against those strategies. NetDimensions’ ranking as a Leader due to its ...
(Date:5/23/2017)... ... May 23, 2017 , ... Kathy Goin is ... Clinical Operations. She brings years of expertise in establishing and leading clinical operations ... as a licensed occupational therapist, through a variety of leadership roles in Clinical ...
(Date:5/22/2017)... ... May 22, 2017 , ... Stratevi, a boutique firm that partners ... Coast. It has opened an office in downtown Boston at 745 Atlantic Ave. ... more important to generate evidence on the value they provide, not just to patients, ...
Breaking Biology Technology: