Navigation Links
Drugs found to both prevent and treat Alzheimer's disease in mice
Date:5/21/2013

Researchers at USC have found that a class of pharmaceuticals can both prevent and treat Alzheimer's Disease in mice.

The drugs, known as "TSPO ligands," are currently used for certain types of neuroimaging.

"We looked at the effects of TSPO ligand in young adult mice when pathology was at an early stage, and in aged mice when pathology was quite severe," said lead researcher Christian Pike of the USC Davis School of Gerontology. "TSPO ligand reduced measures of pathology and improved behavior at both ages."

The team's findings were published online by the Journal of Neuroscience on May 15. Pike's coauthors include USC postdoctoral scientists Anna M. Barron, Anusha Jayaraman and Joo-Won Lee; as well as Donatella Caruso and Roberto C. Melcangi of the University of Milan and Luis M. Garcia-Segura of the Instituto Cajal in Spain.

The most surprising finding for Pike and his team was the effect of TSPO ligand in the aged mice. Four treatmentsonce per week over four weeksin older mice resulted in a significant decrease of Alzheimer's-related symptoms and improvements in memory meaning that TSPO ligands may actually reverse some elements of Alzheimer's disease.

"Our data suggests the possibility of drugs that can prevent and treat Alzheimer's," Pike said. "It's just mouse data, but extremely encouraging mouse data. There is a strong possibility that TSPO ligands similar to the ones used in our study could be evaluated for therapeutic efficacy in Alzheimer's patients within the next few years."

Next, the team will next focus on understanding how TSPO ligands reduce Alzheimer's disease pathology. Building on the established knowledge that TSPO ligands can reduce inflammationshielding nerve cells from injury and increasing the production of neuroactive hormones in the brainthe team will study which of these actions is the most significant in fighting Alzheimer's disease so they can develop newer TSPO ligands accordingly.


'/>"/>

Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California
Source:Eurekalert

Related biology news :

1. Renaissance in new drugs for rare diseases
2. Renaissance in new drugs for rare diseases: Report in worlds largest scientific socity magazine
3. How do anticancer drugs work?
4. Mapping of cancer cell fuel pumps paves the way for new drugs
5. Co-Q10 deficiency may relate to concern with statin drugs, higher risk of diabetes
6. Cholesterol rafts deliver drugs inside cancer cells
7. Findings to help in design of drugs against virus causing childhood illnesses
8. KU Leuven lab coordinates €9m effort to find new deep-sea drugs
9. Mood-modifying drugs for humans also alter fish behavior
10. Study finds potential to match tumors with known cancer drugs
11. £6.5M in funding to help manufacture the drugs of the future
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2016)... Fla. , Feb. 1, 2016  Wocket® smart wallet ( www.wocketwallet.com ... and television personality, Joey Fatone . Las Vegas ... greet fans. --> Las Vegas , where ... --> The new video ad was filmed at the Consumer ... appeared at the Wocket booth to meet and greet fans. ...
(Date:1/25/2016)... , Jan. 25, 2016  Glencoe Software, the world-leading ... and publication industries, will provide the data management solution ... (NPSC). ... Phenotypic analysis measures the ... organisms, allowing comparisons between states such as health and ...
(Date:1/20/2016)... , Jan. 20, 2016 A market ... to directly benefit from the explosion in genomics knowledge. ... Howe Sound Research. A range of dynamic trends are ... - personalized medicine - pharmacogenomics - pathogen evolution ... with large markets - greater understanding of the role ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... , Feb. 10, 2016 NX Prenatal Inc., ... proprietary NeXosome® technology for early warning of adverse ... most recent study by Dr. Thomas McElrath ... Society for Maternal Fetal Medicine,s (SMFM) annual meeting held ... th , 2016.  The presentation reported initial positive ...
(Date:2/10/2016)... New York, and New York, New York (PRWEB) , ... ... ... Regeneron Pharmaceuticals Inc. (NASDAQ: REGN) today announced that it ... and develop new vaccines and immunotherapies for infectious diseases and cancer. ...
(Date:2/10/2016)... , Feb. 10, 2016  Allergan plc (NYSE: ... announced that Brent Saunders , Allergan,s CEO and ... a fireside chat session at the RBC Capital Markets ... p.m. ET at The New York Palace Hotel in ... will be webcast live and can be accessed on ...
(Date:2/10/2016)... Austin, Texas (PRWEB) , ... February 10, 2016 ... ... research centers across three states, announced today the promotion of two long-standing principal ... and Chief of Family Medicine, Clinical Research and Development. , Dr. Laurence Chu, ...
Breaking Biology Technology: