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Drug shown to reverse radioiodine resistance in some advanced thyroid cancers
Date:2/13/2013

NRAS gene mutation, selumetinib increased iodine uptake enough to allow patients to undergo RAI therapy.

Following RAI, five patients had confirmed partial responses and three had stable disease. In seven of the eight patients, outcomes remained unchanged during six months of follow-up. All eight patients had a decreased level of serum thyroglobulin a protein in the blood used to screen for advanced thyroid cancer and none experienced serious side effects from selumetinib.

"An advantage of this therapeutic strategy is that only a short course of drug therapy is required to elicit a significant clinical effect," Fagin said, adding that "the initial results show promise for RAS-mutant disease, but the hope is that a larger trial will shed light on whether selumetinib can be effective for a broader range of advanced thyroid cancer subtypes."

Memorial Sloan-Kettering will lead the international, multicenter phase III clinical trial of selumetinib later this year. The trial, which will be sponsored by AstraZeneca, will enroll patients who have recently had their thyroid gland removed a procedure known as total thyroidectomy due to thyroid cancer that has spread to nearby tissue or lymph nodes.


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Contact: Caitlin Hool
HOOLC@MSKCC.ORG
212-639-3573
Memorial Sloan-Kettering Cancer Center
Source:Eurekalert

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