Navigation Links
Drug 'shield' helps target antibiotic resistant bacteria
Date:7/7/2011

A new technique which targets antibiotic-resistant bacteria and shields patients from the toxic parts of an antibiotic drug has been developed by Cardiff University scientists.

Dr Elaine Ferguson from Cardiff University's School of Dentistry has utilised a new technique which attaches tiny nano-sized biodegradable polymers to the antibiotic drug - colistin.

Use of the drug colistin to fight infection has been limited as it is known to be toxic to the kidneys and nerves despite the fact that it has been found to be effective against new multi-drug resistant bacteria, like NDM-1.

Cardiff University scientists believe the new technique will help under-used antibiotic drugs like colistin to be used to fight against the spread of life-threatening bacterial infections.

"The technology we've developed came as a direct response to an urgent medical need for better antibiotics to safely treat patients with life threatening infections. Very few new antimicrobial drugs have emerged despite intensive research, with only two new classes of antibiotics developed in the last 30 years," according to Dr Ferguson who worked alongside Cardiff University's Professor David Thomas and Professor Timothy Walsh to develop the technique.

"Our new approach allows existing effective therapies to be improved to help patients with severe infections who may otherwise suffer significant side effects after treatment.

"The polymer shields the drug molecule making it less toxic to the body while, at sites of infection, there is an enzyme present which removes the polymer- specifically activating the drug where it is needed" she added.

The research was supported by The Severnside Alliance for Translational Research (SARTRE) - a major collaboration between Cardiff and Bristol Universities designed to translate medical research to improve lives.

The seedcorn funding for the research from SARTRE, through the Medi
'/>"/>

Contact: Dr Corinne Squire
029-207-44190
Cardiff University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Shielding body protects brain from shell shocking blast injuries
2. U Alberta find could shield humans from influenza virus
3. Orbel Introduces the Board Shielding Wizard
4. Bacteria launch a shield to resist attack
5. Lotus-plant-inspired dust-busting shield to protect space gear
6. Life Sciences Discovery Fund helps launch 3 programs to advance health research and development
7. Landsat 5 satellite helps emergency managers fight largest fire in Arizona history
8. Hormone test helps predict success in IVF
9. USC: Active social, spiritual and physical life helps prevent health decline in seniors
10. Reforestation research in Latin America helps build better forests
11. Social network helps in discovery of a species of plant lice for the first time in Europe
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... protein, discovered in 2005, controls T-cell activation and ... In doing so, it helps to guarantee immunological ... own structures that can lead to autoimmune disease. ... affect between five and ten per cent of ... of complex environmental influences when a genetic predisposition ...
(Date:7/14/2014)... 140 years ago, Charles Darwin noticed something peculiar about ... are more tame, and they also tend to display ... patches of white fur, and more juvenile faces with ... pattern has proved elusive, but now, in a Perspectives ... new hypothesis has been proposed that could explain why ...
(Date:7/13/2014)... women suggests that experiencing one or more stressful events ... slow the body,s metabolism, potentially contributing to weight gain. ... stressors before giving them a meal consisting of 930 ... measured their metabolic rate how long it took ... took measures of blood sugar, triglycerides, insulin and the ...
Breaking Biology News(10 mins):Molecular mechanisms underlying the prevention of autoim-munity by Roquin revealed 2Domestication syndrome: White patches, baby faces and tameness 2Weighty issue: Stress and high-fat meals combine to slow metabolism in women 2Weighty issue: Stress and high-fat meals combine to slow metabolism in women 3Weighty issue: Stress and high-fat meals combine to slow metabolism in women 4
... electronic skin, or e-skin, and electronic eye implants or ... Researchers with Berkeley Lab and the University of California ... of carbon nanotubes and silver nanoparticles similar to the ... e-whiskers respond to pressure as slight as a single ...
... of men,s bones - but only if they marry when they,re ... In a study published online in the peer-reviewed journal Osteoporosis ... were younger than 25 had lower bone strength than men who ... In addition, men in stable marriages or ...
... climate. Take, for example, the Mayans, who, throughout the ... their major ceremonial centers after a series of multi-year droughts, ... forests. Much later, in the late 20th century, frequent droughts ... migrate from the dry north to the wetter south where ...
Cached Biology News:E-whiskers 2Guys: Get married for the sake of your bones, but wait until you're 25 2Guys: Get married for the sake of your bones, but wait until you're 25 3Princeton model anticipates ecological impacts of human responses to climate 2Princeton model anticipates ecological impacts of human responses to climate 3
(Date:7/14/2014)... 14, 2014 Throughout this past ... the clinical trials space, representing 38 countries globally, ... entitled “Optimizing Patient Participation in Clinical Trials. Attract. ... with internationally renowned R&D expert, Ken Getz, of ... Reinventing Drug Development through Patient Centricity. , Throughout ...
(Date:7/13/2014)... 2014 Deep Research Report on Global and ... study on the current state of the Nano Silver ... a basic overview of the industry, including definitions, applications ... domestic market analysis are provided with a focus on ... A comparison between the international and Chinese situation is ...
(Date:7/11/2014)... , July 11, 2014 Research ... "International Transfection Technology Market - Global Industry Analysis, Size, ... to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... introduce nucleic acids (either DNA or RNA) into cells. ... mutation of cancer cells and protein metabolism by affecting ...
(Date:7/11/2014)... , July 11, 2014  Researchers have ... three-dimensional images. The new technology, called Virtual Finger, ... small structures like neurons and synapses using the ... unique technology makes 3D imaging studies orders of ... at an unprecedented level across many areas of ...
Breaking Biology Technology:Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 2Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 3Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 4Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 52014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 22014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 3International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3
... , for routine high fidelity amplification of up to 3.5 kb , ... 100 units , Cat. No. 1 664 955 ... , , Description , , , ... archaebacterium Pyrococcus woesei. The enzyme has a molecular weight of , ...
... , for routine amplification of up to 3 kb genomic DNA ... , , , , , ... contains 10 vials of 2x concentrated PCR reaction , mix (Taq ... dNTPs) plus water PCR grade (for dilution), sufficient for 100 , ...
... for amplification of up to 5 kb targets from genomic DNA ... , , , , , ... concentrated High Fidelity PCR Master contains all necessary , reagents ... a unique enzyme blend of Taq DNA Polymerase and Pwo DNA Polymerase[a thermostable , ...
Cached Biology Technology:Pwo DNA Polymerase 2Pwo DNA Polymerase 3PCR Master 2PCR Master 3High Fidelity PCR Master 2