Navigation Links
Drug 'shield' helps target antibiotic resistant bacteria
Date:7/7/2011

A new technique which targets antibiotic-resistant bacteria and shields patients from the toxic parts of an antibiotic drug has been developed by Cardiff University scientists.

Dr Elaine Ferguson from Cardiff University's School of Dentistry has utilised a new technique which attaches tiny nano-sized biodegradable polymers to the antibiotic drug - colistin.

Use of the drug colistin to fight infection has been limited as it is known to be toxic to the kidneys and nerves despite the fact that it has been found to be effective against new multi-drug resistant bacteria, like NDM-1.

Cardiff University scientists believe the new technique will help under-used antibiotic drugs like colistin to be used to fight against the spread of life-threatening bacterial infections.

"The technology we've developed came as a direct response to an urgent medical need for better antibiotics to safely treat patients with life threatening infections. Very few new antimicrobial drugs have emerged despite intensive research, with only two new classes of antibiotics developed in the last 30 years," according to Dr Ferguson who worked alongside Cardiff University's Professor David Thomas and Professor Timothy Walsh to develop the technique.

"Our new approach allows existing effective therapies to be improved to help patients with severe infections who may otherwise suffer significant side effects after treatment.

"The polymer shields the drug molecule making it less toxic to the body while, at sites of infection, there is an enzyme present which removes the polymer- specifically activating the drug where it is needed" she added.

The research was supported by The Severnside Alliance for Translational Research (SARTRE) - a major collaboration between Cardiff and Bristol Universities designed to translate medical research to improve lives.

The seedcorn funding for the research from SARTRE, through the Medi
'/>"/>

Contact: Dr Corinne Squire
029-207-44190
Cardiff University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Shielding body protects brain from shell shocking blast injuries
2. U Alberta find could shield humans from influenza virus
3. Orbel Introduces the Board Shielding Wizard
4. Bacteria launch a shield to resist attack
5. Lotus-plant-inspired dust-busting shield to protect space gear
6. Life Sciences Discovery Fund helps launch 3 programs to advance health research and development
7. Landsat 5 satellite helps emergency managers fight largest fire in Arizona history
8. Hormone test helps predict success in IVF
9. USC: Active social, spiritual and physical life helps prevent health decline in seniors
10. Reforestation research in Latin America helps build better forests
11. Social network helps in discovery of a species of plant lice for the first time in Europe
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... in French . ... from African soils looming as a major threat to food ... that over the last five years, 1.7 million African farmers ... 1.6 million hectares and helped them double or even triple ... Green Revolution in Africa (AGRA) focuses on intensive efforts initiated ...
(Date:8/22/2014)... MD FASEB MARC (Maximizing Access to Research Careers) ... FASEB Grant Writing Seminar & Practical Exercises Workshop which ... Bethesda, Maryland from August 25-26, 2014. These awards ... and research scientists from underrepresented groups in the the ... This year MARC conferred 11 awards totaling $20,350. , ...
(Date:8/22/2014)... important discoveries in basic and clinical research and ... into a complex offensive spanning multiple fronts. , ... lab could help find new and more selective ... that targets a specific enzyme overexpressed in certain ... from brain tumours. , Chemistry professor Christopher Cairo ...
Breaking Biology News(10 mins):Effort to confront Africa's soil health crisis helps millions of farmers triple yields 2Effort to confront Africa's soil health crisis helps millions of farmers triple yields 3Effort to confront Africa's soil health crisis helps millions of farmers triple yields 4New enzyme targets for selective cancer therapies 2New enzyme targets for selective cancer therapies 3
... to better understand the Klamath River basin ecosystem. ... says for the studies to prove more useful for ... be completed to identify all research and management needs. ... help reconstruct pre-development flows -- without dams or irrigation ...
... a slight or no advantage to each individual man ... same tribe...an advancement in the standard of morality will ... another. With these words, Charles Darwin ... individuals behaving for the good of their group, often ...
... A new test can identify take-away paper-based food containers ... The phthalates (plasticisers) are present because the containers were ... paper and cardboard. In Italy, where the test was ... food packaging breaks food safety rules. Recycling paper ...
Cached Biology News:More comprehensive analysis of Klamath River basin needed to aid decision makers 2More comprehensive analysis of Klamath River basin needed to aid decision makers 3More comprehensive analysis of Klamath River basin needed to aid decision makers 4Group selection, a theory whose time has come...again 2New test finds diisobutyl phthalate in some cardboard food packaging -- recycling is the issue 2
(Date:8/22/2014)... intensively investigated for application as catalysts, sensors, ... components in photonics and molecular electronics. Gaining ... understanding physical and chemical properties, has been ... have demonstrated that high-resolution electron microscopy can ... in which all gold atoms are observed. ...
(Date:8/22/2014)... 22, 2014 The AMA is pleased ... members in Alaska that Alaska Governor Sean Parnell has ... further defining public use of Unmanned Aircraft Systems and ... House Bill 255states that it is, “An Act relating ... by an unmanned aircraft system.” It defines State of ...
(Date:8/21/2014)... Rockville, MD (PRWEB) August 21, 2014 ... is making progress in its development of JRC-LAMP-vax, an ... red cedar pollen. Phase IC studies began this month ... solution to hay fever. , The Japanese red cedar ... million people in Japan. Mountain Cedar pollen wreaks similar ...
(Date:8/21/2014)... His Majesty Willem-Alexander, King of the ... of His Majesty Willem-Alexander, King of the Netherlands, has ... of POET-DSM Advanced Biofuels’ Project LIBERTY cellulosic ethanol plant ... King will take part in the Grand Opening Ceremony ... a.m.-12:20 p.m. and tour the plant. POET-DSM is a ...
Breaking Biology Technology:A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy 2State of Alaska Signs Unmanned Aircraft Systems Bill 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3
... , , , , ... and proteins has established itself as a routine method in many ... and in the visibility , range. Proteins are measured ... nm and colorimetric protein determination is carried out in the range from , ...
... for disease states or pathogens , Gabriela ... S. Nichols , Stratagene is introducing PCR primer ... The sequences of these primers have been published ... sets, medical researchers,can use PCR technology to identify ...
... Taq DNA polymerase utilizes ultra-pure ,Taq2000 ... DNA polymerase ,features a modified version of ... start capability. Using SureStart Taq, hot start is ,in- corporated ... little or no modification of cycling parameters or reaction ,conditions. ...
Cached Biology Technology:Quantification made easy 2Quantification made easy 3New PCR Primers for Human Diseases 2New PCR Primers for Human Diseases 3New PCR Primers for Human Diseases 4Improve Amplification Specificity with Hot Start PCR Enzyme 2Improve Amplification Specificity with Hot Start PCR Enzyme 3
Human/Mouse/Rat AMPK beta 1 Affinity Purified Polyclonal Ab...
Immunogen: Tissue / cell preparation. (Murine EHS laminin preparation) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Human Carnosine Dipeptidase 1 Affinity Purified PAb...
Mouse monoclonal [Flt-1/EWC] to VEGF Receptor 1 ( Abpromise for all tested applications). entrezGeneID: 2321 SwissProtID: P17948...
Biology Products: