Navigation Links
Drug 'shield' helps target antibiotic resistant bacteria
Date:7/7/2011

A new technique which targets antibiotic-resistant bacteria and shields patients from the toxic parts of an antibiotic drug has been developed by Cardiff University scientists.

Dr Elaine Ferguson from Cardiff University's School of Dentistry has utilised a new technique which attaches tiny nano-sized biodegradable polymers to the antibiotic drug - colistin.

Use of the drug colistin to fight infection has been limited as it is known to be toxic to the kidneys and nerves despite the fact that it has been found to be effective against new multi-drug resistant bacteria, like NDM-1.

Cardiff University scientists believe the new technique will help under-used antibiotic drugs like colistin to be used to fight against the spread of life-threatening bacterial infections.

"The technology we've developed came as a direct response to an urgent medical need for better antibiotics to safely treat patients with life threatening infections. Very few new antimicrobial drugs have emerged despite intensive research, with only two new classes of antibiotics developed in the last 30 years," according to Dr Ferguson who worked alongside Cardiff University's Professor David Thomas and Professor Timothy Walsh to develop the technique.

"Our new approach allows existing effective therapies to be improved to help patients with severe infections who may otherwise suffer significant side effects after treatment.

"The polymer shields the drug molecule making it less toxic to the body while, at sites of infection, there is an enzyme present which removes the polymer- specifically activating the drug where it is needed" she added.

The research was supported by The Severnside Alliance for Translational Research (SARTRE) - a major collaboration between Cardiff and Bristol Universities designed to translate medical research to improve lives.

The seedcorn funding for the research from SARTRE, through the Medi
'/>"/>

Contact: Dr Corinne Squire
029-207-44190
Cardiff University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Shielding body protects brain from shell shocking blast injuries
2. U Alberta find could shield humans from influenza virus
3. Orbel Introduces the Board Shielding Wizard
4. Bacteria launch a shield to resist attack
5. Lotus-plant-inspired dust-busting shield to protect space gear
6. Life Sciences Discovery Fund helps launch 3 programs to advance health research and development
7. Landsat 5 satellite helps emergency managers fight largest fire in Arizona history
8. Hormone test helps predict success in IVF
9. USC: Active social, spiritual and physical life helps prevent health decline in seniors
10. Reforestation research in Latin America helps build better forests
11. Social network helps in discovery of a species of plant lice for the first time in Europe
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/14/2014)... tumors scavenge and hoard copper that is an essential ... a fatal weakness. , Researchers at Duke Medicine ... by delivering a trove of copper along with a ... the mineral, leaving non-cancer cells healthy. , The combination ... other uses, could soon be tested in clinical trials ...
(Date:10/14/2014)... – Scientists have sequenced the house fly genome for ... might expect from an insect that thrives in pathogen-rich ... Oct. 14 in the journal Genome Biology , ... and of how flies quickly adapt to resist insecticides, ... house flies (Musca domestica) carry and transmit more than ...
(Date:10/14/2014)... oil supplements, rich in omega-3 fatty acids, do not reduce ... the heart can beat as fast as 150 beats a ... Montreal Heart Institute were published in the Journal of ... For the trial, 337 patients with atrial fibrillation not receiving ... fish oil a day or to placebo for up to ...
Breaking Biology News(10 mins):Prostate cancer's penchant for copper may be a fatal flaw 2House fly genome reveals expanded immune system 2
... the number of people likely to inhabit the planet on ... argue that it is not simply the number of people ... health status and location that is most relevant to local ... development must focus primarily on the human wellbeing and be ...
... 2011)Guided by insights into how mice recover after H1N1 flu, ... together with researchers at A*STAR of Singapore, have cloned three ... one of these cells can form into the lung,s alveoli ... same lung stem cells are rapidly deployed in a dynamic ...
... , Multiple sclerosis is caused by a combination of ... were believed to be such external influences. According to ... Martinsried, however, it is apparently not harmful bacteria ... the natural intestinal flora, which every human being needs ...
Cached Biology News:7 billion people are not the issue - human development is what counts 27 billion people are not the issue - human development is what counts 3Lung stem cells offer therapeutic clues 2Natural intestinal flora involved in the emergence of multiple sclerosis 2Natural intestinal flora involved in the emergence of multiple sclerosis 3
(Date:10/17/2014)... Air Force Office of Scientific Research grant to examine ... that will provide clues for predicting fatigue in aircraft ... said the new technology and process would be better ... wing., "We,ll be able to determine metal fatigue at ... this scale," Huang said. "Certain patterns of surface roughness ...
(Date:10/17/2014)... HILDEN, Germany , October 17, ... , Translational research in cancer and other diseases ... the American Society of Human Genetics annual meeting ... linked to Ingenuity ®  Knowledge Base greatly exceeds ... Ingenuity ®  Variant Analysis™ adds fully ...
(Date:10/17/2014)... 2014 Bioquell, provider of germ-eliminating ... health facilities around the world to decontaminate locations ... Among the many places the hydrogen peroxide vapor ... Hospital Dallas and at the National Institutes of ... have been utilized to decontaminate patient rooms, equipment, ...
(Date:10/17/2014)... The global SWIR market report defines and ... of revenue. This market is valued at $60.1 million ... by 2019, at a CAGR of 10.2% from 2014 ... global SWIR market report, to get an idea of ... of the segmentation of the market, and is supported ...
Breaking Biology Technology:UT Arlington project to detect possible damages in aircraft parts early in process 2QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 2QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 3QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 4QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 5QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 6Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 3Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 5Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 6The global SWIR market is expected to reach $97.9 million by 2019 - New Report by MicroMarket Monitor 2The global SWIR market is expected to reach $97.9 million by 2019 - New Report by MicroMarket Monitor 3
... as the first to demonstrate how an electron,s spin ... electrical engineers from the University of Delaware and Cambridge ... transported a marathon distance in the world of microelectronics-- ... that silicon--the workhorse material of present-day electronics--now can be ...
... SAN DIEGO, Oct. 26 AMN Healthcare Services,Inc. ... staffing company, is,scheduled to make a presentation on ... at the BIOCOM Investor Conference 2007 taking place ... San Diego. (Logo: http://www.newscom.com/cgi-bin/prnh/20060718/LATU121LOGO ) ...
... support of clinical research protocol development, ECG services, ... Quintiles,Transnational Corp. today announced that Christopher H. Cabell, ... has joined the,Medical & Scientific Services group in ... CDS work, he provides U.S.-based cardiology,expertise for Quintiles ...
Cached Biology Technology:UD researchers race ahead with latest spintronics achievement 2AMN Healthcare Services to Present at the BIOCOM Investor Conference 2007 2Expert Cardiologist Joins Quintiles Medical Group 2
Request Info...
These macrocarriers are for the biolistic PDS-1000 He and Hepta systems. Supplied as 500 macrocarriers....
... Anti-phospho-Hck [pTyr 209/ pSer 211 ] affinity ... in Dulbecco's phosphate buffered saline (without Mg 2+ ... 1.0 mg/ml BSA (IgG and protease free) and ... from the region of mouse Hck that contains ...
High voltage electrophoresis power supply...
Biology Products: